3.4.22.10: streptopain
This is an abbreviated version!
For detailed information about streptopain, go to the full flat file.
Word Map on EC 3.4.22.10
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3.4.22.10
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speb
-
streptococci
-
glomerulonephritis
-
zymogen
-
fasciitis
-
superantigens
-
streptolysin
-
nephritogenic
-
streptokinase
-
poststreptococcal
-
scarlet
-
apsgn
-
shock-like
- 3.4.22.10
- speb
- streptococci
- glomerulonephritis
- zymogen
- fasciitis
-
superantigens
-
streptolysin
-
nephritogenic
- streptokinase
-
poststreptococcal
-
scarlet
-
apsgn
-
shock-like
Reaction
preferential cleavage with hydrophobic residues at P2, P1 and P1' =
Synonyms
EC 3.4.4.18, IdeS, IgG-degrading enzyme of Streptococcus pyogenes, interleukin-1beta convertase, More, proteinase, streptococcal, pyrogenic exotoxin B, SCP, SpcCEP, Spe B, SPE B protease, SPE B/SCP, SpeB, SPP, Steptococcus proteinase, streptococcal cysteine protease, Streptococcal cysteine proteinase, streptococcal erythrogenic toxin B, streptococcal proteinase, streptococcal pyogenic exotoxin B, streptococcal pyrogenic exotoxin B, streptococcal pyrogenic exotoxin B/cysteine protease, Streptococcus peptidase A, Streptococcus protease, streptopain
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Reference on EC 3.4.22.10 - streptopain
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Liu, T.Y.; Elliott, S.D.
Streptococcal proteinase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
3
609-647
1971
Streptococcus sp.
-
Ashbaugh, C.D.; Warren, H.B.; Carey, V.J.; Wessels, M.R.
Molecular analysis of the role of the group A streptococcal cysteine protease, hyaluronic acid capsule, and M protein in a murine model of human invasive soft-tissue infection
J. Clin. Invest.
102
550-560
1998
Streptococcus sp.
Doran, J.D.; Nomizu, M.; Takebe, S.; Menard, R.; Griffith, D.; Ziomek, E.
Autocatalytic processing of the streptococcal cysteine protease zymogen: processing mechanism and characterization of the autoproteolytic cleavage sites
Eur. J. Biochem.
263
145-151
1999
Streptococcus pyogenes, Streptococcus pyogenes B220
Green, G.D.J.; Shaw, E.
Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases
J. Biol. Chem.
256
1923-1928
1981
Streptococcus sp.
Kortt, A.A.; Wysocki, J.R.; Liu, T.Y.
Primary structure of streptococcal proteinase. I Isolation, composition, and amino acid sequences of the tryptic and chymotryptic peptides of cyanogen bromide fragments 1 to 4
J. Biol. Chem.
251
1941-1947
1976
Streptococcus sp.
Berge, A.; Björck, L.
Streptococcal cysteine proteinase releases biologically active fragments of streptococcal surface proteins
J. Biol. Chem.
270
9862-9867
1995
Streptococcus pyogenes
Tai, J.Y.; Kortt, A.A.; Liu, T.Y.; Elliott, S.D.
Primary structure of streptococcal proteinase. III. Isolation of cyanogen bromide peptides: complete covalent structure of the polypeptide chain
J. Biol. Chem.
251
1955-1959
1976
Streptococcus sp.
Kortt, A.A.; Liu, T.Y.
On the mechanism of action of streptococcal proteinase. I. Active-site titration
Biochemistry
12
320-327
1973
Streptococcus sp.
Kortt, A.A.; Liu, T.Y.
On the mechanism of action of streptococcal proteinase. II. Comparison of the kinetics of proteinase- and papain-catalyzed hydrolysis of N-acylamino acid esters
Biochemistry
12
328-337
1973
Streptococcus sp.
Kortt, A.A.; Liu, T.Y.
On the mechanism of action of streptococcal proteinase. 3. The effect of pH, organic solvents, and deuterium oxide on the proteinase-catalyzed hydrolysis of N-acylamino acid esters
Biochemistry
12
338-345
1973
Streptococcus sp.
Elliott, S.D.; Liu, T.Y.
Streptococcal proteinase
Methods Enzymol.
19
252-261
1970
Streptococcus sp.
-
Stockbauer, K.E.; Magoun, L.; Liu, M.; Burns, E.H.; Gubba, S.; Renish, S.; Pan, X.; Bodary, S.C.; Baker, E.; Coburn, J.; Leong, J.M.; Musser, J.M.
A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid (RGD) motif preferentially binds human integrins alphavbeta3 and alphaIIbbeta3
Proc. Natl. Acad. Sci. USA
96
242-247
1999
Streptococcus sp.
Burns, E.H.; Marciel, A.; Musser, J.M.
Structure-function and pathogenesis studies of Streptococcus pyogenes extracellular cysteine protease
Adv. Exp. Med. Biol.
418
589-592
1997
Streptococcus pyogenes
Liu, T.Y.; Elliott, S.D.
Streptococcal proteinase: the zymogen to enzyme transformation
J. Biol. Chem.
240
1138-1142
1965
Streptococcus pyogenes
Gerwin, B.I.; Stein, W.H.; Moore, S.
On the specificity of streptococcal proteinase
J. Biol. Chem.
241
3331-3339
1966
Streptococcus sp.
Burns, E.H.; Marciel, A.M.; Musser, J.M.
Activation of a 66-kilodalton human endothelial cell matrix metalloprotease by Streptococcus pyogenes extracellular cysteine protease
Infect. Immun.
64
4744-4750
1996
Streptococcus pyogenes
Herwald, H.; Collin, M.; Muller-Esterl, W.; Björck, L.
Streptococcal cysteine proteinase releases kinins: a virulence mechanism
J. Exp. Med.
184
665-673
1996
Streptococcus pyogenes
Chaussee, M.S.; Phillips, E.R.; Ferretti, J.J.
Temporal production of streptococcal erythrogenic toxin B (streptococcal cysteine proteinase) in response to nutrient depletion
Infect. Immun.
65
1956-1959
1997
Streptococcus pyogenes
Tsai, P.J.; Kuo, C.F.; Lin, K.Y.; Lin, Y.; Lei, H.Y.; Chen, F.F.; Wang, J.R.; Wu, J.J.
Effect of group A streptococcal cysteine protease on invasion of epithelial cells
Infect. Immun.
66
1460-1466
1998
Streptococcus pyogenes
Matsuka, Y.V.; Pillai, S.; Gubba, S.; Musser, J.M.; Olmstedt, S.B.
Fibrinogen cleavage by the Streptococcus pyogenes extracellular cysteine protease and generation of antibodies that inhibit enzyme proteolytic activity
Infect. Immun.
67
4326-4333
1999
Streptococcus pyogenes
Lukomski, S.; Montgomery, C.A.; Rurangirwa, J.; Geske, R.S.; Barrish, J.P.; Adams, G.J.; Musser, J.M.
Extracellular cysteine protease produced by Streptococcus pyogenes participates in the pathogenesis of invasive skin infection and dissemination in mice
Infect. Immun.
67
1779-1788
1999
Streptococcus pyogenes
Eriksson, A.; Norgren, M.
The superantigenic activity of streptococcal pyrogenic exotoxin B is independent of the protease activity
FEMS Immunol. Med. Microbiol.
25
355-363
1999
Streptococcus sp., Streptococcus sp. T10BW
von Pawel-Rammingen, U.; Johansson, B.P.; Bjorck, L.
IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G
EMBO J.
21
1607-1615
2002
Streptococcus pyogenes
Eriksson, A.; Norgren, M.
Cleavage of antigen-bound immunoglobulin G by SpeB contributes to streptococcal persistence in opsonizing blood
Infect. Immun.
71
211-217
2003
Streptococcus sp., Streptococcus sp. T1BRB
Kagawa, T.F.; Cooney, J.C.; Baker, H.M.; McSweeney, S.; Liu, M.; Gubba, S.; Musser, J.M.; Baker, E.N.
Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: an integrin-binding cysteine protease
Proc. Natl. Acad. Sci. USA
97
2235-2240
2000
Streptococcus pyogenes (P0C0J0), Streptococcus pyogenes
Anderson, E.T.; Winter, L.A.; Fernsten, P.; Olmsted, S.B.; Matsuka, Y.V.
The pro-sequence domain of streptopain directs the folding of the mature enzyme
Arch. Biochem. Biophys.
436
297-306
2005
Streptococcus pyogenes
Tsao, N.; Tsai, W.H.; Lin, Y.S.; Chuang, W.J.; Wang, C.H.; Kuo, C.F.
Streptococcal pyrogenic exotoxin B cleaves properdin and inhibits complement-mediated opsonophagocytosis
Biochem. Biophys. Res. Commun.
339
779-784
2006
Streptococcus pyogenes
Watts, A.B.; Brocklehurst, K.
Streptopain
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press
2
1245-1249
2004
Streptococcus pyogenes
-
Ohkuni, H.; Todome, Y.; Watanabe, Y.; Ishikaw, T.; Takahashi, H.; Kannari, Y.; Kato, H.; Uchiyama, T.; Saito, H.; Fischetti, V.A.; Zabriskie, J.B.
Studies of recombinant streptococcal pyrogenic exotoxin B/cysteine protease (rSPE B/SCP) in the skin of guinea pigs & the release of histamine from cultured mast cells & basophilic leukocytes
Indian J. Med. Res.
119 Suppl
33-36
2004
Streptococcus pyogenes
Tsai, W.H.; Chang, C.W.; Chuang, W.J.; Lin, Y.S.; Wu, J.J.; Liu, C.C.; Chang, W.T.; Lin, M.T.
Streptococcal pyrogenic exotoxin B-induced apoptosis in a549 cells is mediated by a receptor- and mitochondrion-dependent pathway
Infect. Immun.
72
7055-7062
2004
Streptococcus pyogenes, Streptococcus pyogenes A-20
Wei, L.; Pandiripally, V.; Gregory, E.; Clymer, M.; Cue, D.
Impact of the SpeB protease on binding of the complement regulatory proteins factor H and factor H-like protein 1 by Streptococcus pyogenes
Infect. Immun.
73
2040-2050
2005
Streptococcus pyogenes
Chiang-Ni, C.; Wang, C.H.; Tsai, P.J.; Chuang, W.J.; Lin, Y.S.; Lin, M.T.; Liu, C.C.; Wu, J.J.
Streptococcal pyrogenic exotoxin B causes mitochondria damage to polymorphonuclear cells preventing phagocytosis of group A streptococcus
Med. Microbiol. Immunol.
195
55-63
2006
Streptococcus pyogenes
Nyberg, P.; Rasmussen, M.; Von Pawel-Rammingen, U.; Bjoerck, L.
SpeB modulates fibronectin-dependent internalization of Streptococcus pyogenes by efficient proteolysis of cell-wall-anchored protein F1
Microbiology
150
1559-1569
2004
Streptococcus pyogenes
Kagawa, T.F.; Otoole, P.W.; Cooney, J.C.
SpeB-Spi: a novel protease-inhibitor pair from Streptococcus pyogenes
Mol. Microbiol.
57
650-666
2005
Streptococcus pyogenes, Streptococcus pyogenes B220
Kuo, C.F.; Chen, C.C.; Lin, C.F.; Jan, M.S.; Huang, R.Y.; Luo, Y.H.; Chuang, W.J.; Sheu, C.C.; Lin, Y.S.
Abrogation of streptococcal pyrogenic exotoxin B-mediated suppression of phagocytosis in U937 cells by Cordyceps sinensis mycelium via production of cytokines
Food Chem. Toxicol.
45
278-285
2007
Streptococcus pyogenes
Kuo, C.F.; Lin, Y.S.; Chuang, W.J.; Wu, J.J.; Tsao, N.
Degradation of complement 3 by streptococcal pyrogenic exotoxin B inhibits complement activation and neutrophil opsonophagocytosis
Infect. Immun.
76
1163-1169
2008
Streptococcus pyogenes
Tsai, W.H.; Chang, C.W.; Lin, Y.S.; Chuang, W.J.; Wu, J.J.; Liu, C.C.; Tsai, P.J.; Lin, M.T.
Streptococcal pyrogenic exotoxin B-induced apoptosis in A549 cells is mediated through alpha(v)beta(3) integrin and Fas
Infect. Immun.
76
1349-1357
2008
Streptococcus pyogenes
Nooh, M.M.; Aziz, R.K.; Kotb, M.; Eroshkin, A.; Chuang, W.J.; Proft, T.; Kansal, R.
Streptococcal mitogenic exotoxin, SmeZ, is the most susceptible M1T1 streptococcal superantigen to degradation by the streptococcal cysteine protease, SpeB
J. Biol. Chem.
281
35281-35288
2006
Streptococcus pyogenes
Luo, Y.H.; Kuo, C.F.; Huang, K.J.; Wu, J.J.; Lei, H.Y.; Lin, M.T.; Chuang, W.J.; Liu, C.C.; Lin, C.F.; Lin, Y.S.
Streptococcal pyrogenic exotoxin B antibodies in a mouse model of glomerulonephritis
Kidney Int.
72
716-724
2007
Streptococcus pyogenes (P0C0J0)
Cole, J.N.; Aquilina, J.A.; Hains, P.G.; Henningham, A.; Sriprakash, K.S.; Caparon, M.G.; Nizet, V.; Kotb, M.; Cordwell, S.J.; Djordjevic, S.P.; Walker, M.J.
Role of group A Streptococcus HtrA in the maturation of SpeB protease
Proteomics
7
4488-4498
2007
Streptococcus pyogenes M1 GAS (P0C0J1), Streptococcus pyogenes M1 GAS HSC5 (P0C0J1)
Wang, C.C.; Houng, H.C.; Chen, C.L.; Wang, P.J.; Kuo, C.F.; Lin, Y.S.; Wu, J.J.; Lin, M.T.; Liu, C.C.; Huang, W.; Chuang, W.J.
Solution structure and backbone dynamics of Streptopain
J. Biol. Chem.
284
10957-10967
2009
Streptococcus pyogenes
Soederberg, J.J.; von Pawel-Rammingen, U.
The streptococcal protease IdeS modulates bacterial IgGFc binding and generates 1/2Fc fragments with the ability to prime polymorphonuclear leucocytes
Mol. Immunol.
45
3347-3353
2008
Streptococcus pyogenes
Berggren, K.; Johansson, B.; Fex, T.; Kihlberg, J.; Bjoerck, L.; Luthman, K.
Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant
Bioorg. Med. Chem.
17
3463-3470
2009
Streptococcus pyogenes
Meinert Niclasen, L.; Olsen, J.G.; Dagil, R.; Qing, Z.; Sorensen, O.E.; Kragelund, B.B.
Streptococcal pyogenic exotoxin B (SpeB) boosts the contact system via binding of alpha-1 antitrypsin
Biochem. J.
434
123-132
2011
Streptococcus pyogenes, Streptococcus pyogenes Alab49, Streptococcus pyogenes AP1
Nelson, D.C.; Garbe, J.; Collin, M.
Cysteine proteinase SpeB from Streptococcus pyogenes - a potent modifier of immunologically important host and bacterial proteins
Biol. Chem.
392
1077-1088
2011
Streptococcus pyogenes
Kurupati, P.; Turner, C.E.; Tziona, I.; Lawrenson, R.A.; Alam, F.M.; Nohadani, M.; Stamp, G.W.; Zinkernagel, A.S.; Nizet, V.; Edwards, R.J.; Sriskandan, S.
Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract
Mol. Microbiol.
76
1387-1397
2010
Streptococcus pyogenes, Streptococcus pyogenes H292
Connolly, K.L.; Braden, A.K.; Holder, R.C.; Reid, S.D.
Srv mediated dispersal of streptococcal biofilms through SpeB is observed in CovRS+ strains
PLoS ONE
6
e28640
2011
Streptococcus sp., Streptococcus sp. RGAS053, Streptococcus sp. MGAS315
Persson, H.; Vindebro, R.; von Pawel-Rammingen, U.
The streptococcal cysteine protease SpeB is not a natural immunoglobulin-cleaving enzyme
Infect. Immun.
81
2236-2241
2013
Streptococcus pyogenes
Chella Krishnan, K.; Mukundan, S.; Landero Figueroa, J.A.; Caruso, J.A.; Kotb, M.
Metal-mediated modulation of streptococcal cysteine protease activity and its biological implications
Infect. Immun.
82
2992-3001
2014
Streptococcus pyogenes
Gonzalez-Paez, G.E.; Wolan, D.W.
Ultrahigh and high resolution structures and mutational analysis of monomeric Streptococcus pyogenes SpeB reveal a functional role for the glycine-rich C-terminal loop
J. Biol. Chem.
287
24412-24426
2012
Streptococcus pyogenes, Streptococcus pyogenes ATCC 10782
Sumitomo, T.; Nakata, M.; Higashino, M.; Terao, Y.; Kawabata, S.
Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation
J. Biol. Chem.
288
13317-13324
2013
Streptococcus pyogenes
Brouwer, S.; Cork, A.J.; Ong, C.Y.; Barnett, T.C.; West, N.P.; McIver, K.S.; Walker, M.J.
Endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes
J. Bacteriol.
200
e00654-17
2018
Streptococcus pyogenes (P0C0J0), Streptococcus pyogenes 5448 (P0C0J0)
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