3.4.22.10: streptopain

This is an abbreviated version!
For detailed information about streptopain, go to the full flat file.

Reaction

preferential cleavage with hydrophobic residues at P2, P1 and P1' =

Synonyms

EC 3.4.4.18, IdeS, IgG-degrading enzyme of Streptococcus pyogenes, interleukin-1beta convertase, More, proteinase, streptococcal, pyrogenic exotoxin B, SCP, SpcCEP, Spe B, SPE B protease, SPE B/SCP, SpeB, SPP, Steptococcus proteinase, streptococcal cysteine protease, Streptococcal cysteine proteinase, streptococcal erythrogenic toxin B, streptococcal proteinase, streptococcal pyogenic exotoxin B, streptococcal pyrogenic exotoxin B, streptococcal pyrogenic exotoxin B/cysteine protease, Streptococcus peptidase A, Streptococcus protease, streptopain

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.10 streptopain

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Results	in table
6	Activating Compound
168	AA Sequence
1	CAS Registry Number
16	Cloned(Commentary)
5	Crystallization (Commentary)
2	Expression
12	General Information
5	General Stability
1	IC50 Value
60	Inhibitors
10	kcat/KM [mM/s]
1	Ki Value [mM]
34	KM Value [mM]
7	Localization
2	Metals/Ions
28	Molecular Weight [Da]
68	Natural Substrates/ Products (Substrates)
70	Organism
11	PDB ID
7	pH Optimum
1	pH Stability
15	Posttranslational Modification
37	Protein Variants
15	Purification (Commentary)
3	Reaction
1	Reaction Type
66	Reference
2	Renatured (Commentary)
2	Specific Activity [micromol/min/mg]
2	Storage Stability
165	Substrates and Products (Substrate)
13	Subunits
85	Synonyms
10	Temperature Optimum [°C]
4	Temperature Stability [°C]
32	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.22.10 - streptopain

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

analysis of a crystal structure model of the zymogen

Streptococcus pyogenes

-

667311

crystal structures are determined of mature apo-SpeB at 1.06 A resolution from a crystal obtained in neutral pH conditions and high resolution crystal structures of SpeB in complex with the general proteinase inhibitor trans-epoxysuccinyl- L-leucylamido(4-guanidino)butane (E64) and in complex with the SpeB-specific N-terminal acetylated peptide aldehyde inhibitor acetyl-Ala-Gln-Ile-(S)-2,6-diaminohexanal

Streptococcus pyogenes

-

734185

hanging drop vapour diffusion method, the crystal structure of the C47S mutant zymogen 40000 Da form expressed in Escherichia coli and its SeMet-substituted form, at 1.6 A resolution, reveals that the protein is a distant homologue of the papain superfamily

Streptococcus pyogenes

P0C0J0

653648

purified recombinant mutant C47S, X-ray diffraction crystal structure determination and analysis at 1.6 A resolution

Streptococcus pyogenes

-

668772

-

Streptococcus sp.

-

81451