3.4.21.60: Scutelarin

This is an abbreviated version, for detailed information about Scutelarin, go to the full flat file.

Reaction

selective cleavage of Arg-/-Thr and Arg-/-Ile in prothrombin to form thrombin and two inactive fragments =

Synonyms

cotiaractivase, cotiarinase, EC 3.4.99.28, ecarin, Lopap, Proteinase, Oxyuranus scutellatus prothrombin-activating, prothrombin activator, pseutarin C, scuterin, Taipan activator

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.60 Scutelarin

Molecular Weight

Molecular Weight on EC 3.4.21.60 - Scutelarin

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20800
x * 22500, proprotein, x * 20800, mature protein, calculated
22500
x * 22500, proprotein, x * 20800, mature protein, calculated
22931
-
x * 22931, mass spectroscopy, x * 23000, SDS-PAGE
23000
-
x * 22931, mass spectroscopy, x * 23000, SDS-PAGE
29000
-
x * 29000, SDS-PAGE
32000
-
x * 32000, heavy chain, SDS-PAGE
50000
-
1 * 50000 + x * ?, catalytically active subunit, SDS-PAGE
69000
-
x * 69000, SDS-PAGE
80000
-
x * 110000 + x * 80000 + 2 disulfide-linked polypeptides of MW 30000 (one or both of these contain the active site), Oxyuranus scutellatus, SDS-PAGE after reduction with 2-mercaptoethanol
110000
-
x * 110000 + x * 80000 + 2 disulfide-linked polypeptides of MW 30000 (one or both of these contain the active site), Oxyuranus scutellatus, SDS-PAGE after reduction with 2-mercaptoethanol
220000
300000
-
Oxyuranus scutellatus, nondenaturing PAGE