3.4.21.60: Scutelarin

This is an abbreviated version, for detailed information about Scutelarin, go to the full flat file.

Reaction

selective cleavage of Arg-/-Thr and Arg-/-Ile in prothrombin to form thrombin and two inactive fragments =

Synonyms

cotiaractivase, cotiarinase, EC 3.4.99.28, ecarin, Lopap, Proteinase, Oxyuranus scutellatus prothrombin-activating, prothrombin activator, pseutarin C, scuterin, Taipan activator

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.60 Scutelarin

Reaction

Reaction on EC 3.4.21.60 - Scutelarin

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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
selective cleavage of Arg-/-Thr and Arg-/-Ile in prothrombin to form thrombin and two inactive fragments
show the reaction diagram
From the venom of the Taipan snake (Oxyuranus scutellatus). Converts prothrombin to thrombin. Specificity is similar to that of Factor Xa (EC 3.4.21.6). However, unlike Factor Xa this enzyme can cleave its target in the absence of coagulation Factor Va. Activity is potentiated by phospholipid and Ca2+ which binds via gamma-carboxyglutamic acid residues. Similar enzymes are known from the venom of other Australian elapid snakes, including Pseudonaja textilis textilis, Oxyuranus microlepidotus and Demansia nuchalis affinis.
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