3.4.13.22: D-Ala-D-Ala dipeptidase
This is an abbreviated version!
For detailed information about D-Ala-D-Ala dipeptidase, go to the full flat file.
Word Map on EC 3.4.13.22
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3.4.13.22
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dipeptide
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enterococci
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vancomycin-resistant
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peptidoglycan
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medicine
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d-alanyl-d-lactate
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d-ala-d-lactate
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glycopeptide
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faecium
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carboxypeptidase
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zinc-dependent
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cell-wall
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zinc-containing
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toyocaensis
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tetrahedral
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depsipeptide
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uv-vis
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l-ala-l-ala
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thiophenol
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hedgehog
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enterica
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albus
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vanhax
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kinact
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d,d-dipeptidase
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phosphinate
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synthesis
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analysis
- 3.4.13.22
- dipeptide
-
enterococci
-
vancomycin-resistant
- peptidoglycan
- medicine
-
d-alanyl-d-lactate
- d-ala-d-lactate
- glycopeptide
- faecium
- carboxypeptidase
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zinc-dependent
-
cell-wall
-
zinc-containing
- toyocaensis
-
tetrahedral
-
depsipeptide
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uv-vis
- l-ala-l-ala
- thiophenol
-
hedgehog
- enterica
-
albus
-
vanhax
-
kinact
- d,d-dipeptidase
- phosphinate
- synthesis
- analysis
Reaction
Synonyms
AAD, D-, D-dipeptidase, D-Ala-D-Ala amino dipeptidase, D-Ala-D-Ala dipeptidase, D-Ala-D-Ala dipeptidase VanX, D-Ala-D-Ala-dipeptidase, D-alanyl-D-alanine dipeptidase, M15.011, MAB1843, Vancomycin B-type resistance protein vanX, VanX, VanXY, VanXYc
ECTree
3.4.13.22 D-Ala-D-Ala dipeptidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.13.22 - D-Ala-D-Ala dipeptidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2S)-N-D-alanyl-2-(phenylthio)-glycine + H2O
D-alanine + 2-(phenylthio)-glycine
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-
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?
D-Leu-4-nitroanilide + H2O
D-Leu + 4-nitroaniline
specific but catalytically inefficient substrate
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-
?
D-leucine-p-nitroanilide + H2O
D-leucine + p-nitroaniline
substrate is discovered by construction of a library containing 35 L- and D-amino acid p-nitroanilides
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-
?
D/L-Ala-4-nitroanilide + H2O
?
slight hydrolysis for both isomers
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-
?
D-Ala-D-Ala + H2O
2 D-Ala
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D-Ala-D-Ala hydrolysis with VanX is an exothermic and spontaneous reaction and has an approximative reaction rate with the imipenem hydrolysis with metallo-beta-lactamase ImiS in vitro. The values of activation free energy DELTAG are 87.140 , 88.413 , 89.611 , and 90.823 kJ per mol at 293.15, 298.15, 303.15, and 308.15 K, respectively, activation enthalpy DELTAH is 15.332 kJ per mol, activation entropy DELTAS is -245.02 J per mol and K, apparent activation energy E is 17.830 kJ per mol, and the reaction order is 1.5
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-
?
D-Ala-D-Ala + H2O
D-Ala + D-Ala
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enzyme is essential for vancomycin resistance in Enterococcus faecium
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?
D-Ala-D-Ala + H2O
D-Ala + D-Ala
enzyme is essential for vancomycin resistance in Enterococcus faecium
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?
D-Ala-D-Ala + H2O
D-Ala + D-Ala
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enzyme is required for vancomycin resistance in enterococci
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?
D-Ala-D-Ala + H2O
D-Ala + D-Ala
enzyme is required for vancomycin resistance
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?
D-Ala-D-Ala + H2O
D-Ala + D-Ala
enzyme is required for vancomycin resistance
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?
additional information
?
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bifunctional enzyme catalyzing the reactions of D-Ala-D-Ala-carboxypeptidase EC 3.4.16.4 and D-Ala-D-Ala-dipeptidase EC 3.4.13.22
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-
?
additional information
?
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substrate specificty, no activity with D-Ala-D-lactate
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?
additional information
?
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no substrate: L-Leu-4-nitroanilide
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-
?
