3.4.13.22: D-Ala-D-Ala dipeptidase
This is an abbreviated version!
For detailed information about D-Ala-D-Ala dipeptidase, go to the full flat file.
Word Map on EC 3.4.13.22
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3.4.13.22
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dipeptide
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enterococci
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vancomycin-resistant
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peptidoglycan
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medicine
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d-alanyl-d-lactate
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d-ala-d-lactate
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glycopeptide
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faecium
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carboxypeptidase
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zinc-dependent
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cell-wall
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zinc-containing
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toyocaensis
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tetrahedral
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depsipeptide
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uv-vis
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l-ala-l-ala
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thiophenol
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hedgehog
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enterica
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albus
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vanhax
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kinact
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d,d-dipeptidase
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phosphinate
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synthesis
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analysis
- 3.4.13.22
- dipeptide
-
enterococci
-
vancomycin-resistant
- peptidoglycan
- medicine
-
d-alanyl-d-lactate
- d-ala-d-lactate
- glycopeptide
- faecium
- carboxypeptidase
-
zinc-dependent
-
cell-wall
-
zinc-containing
- toyocaensis
-
tetrahedral
-
depsipeptide
-
uv-vis
- l-ala-l-ala
- thiophenol
-
hedgehog
- enterica
-
albus
-
vanhax
-
kinact
- d,d-dipeptidase
- phosphinate
- synthesis
- analysis
Reaction
Synonyms
AAD, D-, D-dipeptidase, D-Ala-D-Ala amino dipeptidase, D-Ala-D-Ala dipeptidase, D-Ala-D-Ala dipeptidase VanX, D-Ala-D-Ala-dipeptidase, D-alanyl-D-alanine dipeptidase, M15.011, MAB1843, Vancomycin B-type resistance protein vanX, VanX, VanXY, VanXYc
ECTree
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KI Value
KI Value on EC 3.4.13.22 - D-Ala-D-Ala dipeptidase
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0.0165
D-Ala-PSI[P(OOH)O]-D-Ala
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koff: 0.0180 sec-1, results reveals that both dipeptide phosphonates are slow-binding inhibitors of VanX
0.00196
D-Ala-PSI[P(OOH)O]-D-Phe
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koff: 0.00231 sec-1, results reveals that both dipeptide phosphonates are slow-binding inhibitors of VanX. Moreover, in comparison with D-Ala(P,O)D-Ala phosphonate dipeptide, an additional aromatic interaction with the Phe79 residue in the active site of the enzyme may account for its higher affinity to VanX
additional information
additional information
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inhibition kinetics, Ki is 0.0015 mM immediately after addition of the enzyme, but is then lowered to by a relatively slow isomerization step to a second complex to Ki = 0.00047 mM
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