3.4.11.6: aminopeptidase B

This is an abbreviated version!
For detailed information about aminopeptidase B, go to the full flat file.

Reaction

release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys =

Synonyms

AAP, ACE2, Aminopeptidase, aminopeptidase B, aminopeptidase, arginine, aminopeptidase-B, Ap-B, APB, Arg-AP, Arg/Lys aminopeptidase, ArgAP, arginine aminopeptidase, arginine-aminopeptidase, arginyl aminopeptidase, arginyl peptidase, arylamidase, arylamidase II, BSAP, chloride-dependent-basic aminopeptidase, Cl--activated arginine aminopeptidase, Cl--activated arinine aminopeptidase, Co(II)-Ap-B, ColAP, cold-active aminopeptidase, Cu(II)-Ap-B, cytosol aminopeptidase, cytosol aminopeptidase IV, DAP BII, dipeptidyl aminopeptidase BII, double-zinc aminopeptidase, EC 3.4.13.6, KAP, L-arginine aminopeptidase, L-RAP, LAPase, leukocyte-derived arginine aminopeptidase, LRAP, lysine-specific aminopeptidase, minopeptidase, More, protease IV, pumAPE, RAP

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.11 Aminopeptidases

                3.4.11.6 aminopeptidase B

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Results	in table
26	Activating Compound
865	AA Sequence
1	Application
1	CAS Registry Number
19	Cloned(Commentary)
2	Crystallization (Commentary)
426	Disease/ Diagnostics
5	General Information
1	General Stability
48	IC50 Value
386	Inhibitors
18	kcat/KM [mM/s]
14	Ki Value [mM]
91	KM Value [mM]
53	Localization
80	Metals/Ions
46	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
110	Organism
1	Oxidation Stability
5	PDB ID
33	pH Optimum
10	pH Range
5	pH Stability
9	pI Value
5	Posttranslational Modification
35	Protein Variants
40	Purification (Commentary)
6	Reaction
2	Reaction Type
109	Reference
190	Source Tissue
43	Specific Activity [micromol/min/mg]
8	Storage Stability
255	Substrates and Products (Substrate)
20	Subunits
100	Synonyms
20	Temperature Optimum [°C]
5	Temperature Range [°C]
26	Temperature Stability [°C]
57	Turnover Number [1/s]

Application

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Application on EC 3.4.11.6 - aminopeptidase B

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug development

Homo sapiens

P09960

Drug repurposing of histone deacetylase inhibitors that alleviate neutrophilic inflammation in acute lung injury and idiopathic pulmonary fibrosis via inhibiting leukotriene A4 hydrolase and blocking LTB4 biosynthesis

754386