3.4.11.4: tripeptide aminopeptidase

This is an abbreviated version!
For detailed information about tripeptide aminopeptidase, go to the full flat file.

Reaction

release of the N-terminal residue from a tripeptide =

Synonyms

alanine-phenylalanine-proline arylamidase, alpha-aminoacyl-dipeptide hydrolase, aminoexotripeptidase, aminopeptidase, human liver, aminotripeptidase, arginyl tri-peptidase, ec 3.4.1.3, EC 3.4.14.10, imidoendopeptidase, lymphopeptidase, PepB, PepT, peptidase B, peptidase T, prolyl tripeptidyl aminopeptidase, PTP, PTP39, TPP I, TPP II, TPPII, tripeptidase, tripeptidyl aminopeptidase, tripeptidyl exopeptidase II, tripeptidyl peptidase II, tripeptidyl-peptidase I, tripeptidyl-peptidase II

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.11 Aminopeptidases

                3.4.11.4 tripeptide aminopeptidase

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Results	in table
1	Activating Compound
13275	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
3	Crystallization (Commentary)
174	Disease/ Diagnostics
3	General Stability
140	Inhibitors
6	kcat/KM [mM/s]
4	Ki Value [mM]
43	KM Value [mM]
20	Localization
14	Metals/Ions
28	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
48	Organism
7	PDB ID
18	pH Optimum
4	pH Range
2	Posttranslational Modification
18	Protein Variants
26	Purification (Commentary)
1	Reaction
2	Reaction Type
48	Reference
32	Source Tissue
22	Specific Activity [micromol/min/mg]
3	Storage Stability
93	Substrates and Products (Substrate)
15	Subunits
57	Synonyms
8	Temperature Optimum [°C]
4	Temperature Stability [°C]
23	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.11.4 - tripeptide aminopeptidase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

tripeptides + H2O

?

Rattus norvegicus

-

e.g. Met-Leu-Tyr: chemotactic factor, Gly-His-Lys: liver growth factor, slow hydrolysis

35923

-

-

?

additional information

?

-

Arabidopsis thaliana

-

the enzyme digests peptide products of the 26S proteasome and other endopeptidases into tripeptides

666630

-

-

?