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3.4.11.4: tripeptide aminopeptidase

This is an abbreviated version!
For detailed information about tripeptide aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.4

Reaction

release of the N-terminal residue from a tripeptide =

Synonyms

alanine-phenylalanine-proline arylamidase, alpha-aminoacyl-dipeptide hydrolase, aminoexotripeptidase, aminopeptidase, human liver, aminotripeptidase, arginyl tri-peptidase, ec 3.4.1.3, EC 3.4.14.10, imidoendopeptidase, lymphopeptidase, PepB, PepT, peptidase B, peptidase T, prolyl tripeptidyl aminopeptidase, PTP, PTP39, TPP I, TPP II, TPPII, tripeptidase, tripeptidyl aminopeptidase, tripeptidyl exopeptidase II, tripeptidyl peptidase II, tripeptidyl-peptidase I, tripeptidyl-peptidase II

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.4 tripeptide aminopeptidase

Substrates Products

Substrates Products on EC 3.4.11.4 - tripeptide aminopeptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(Gln)17-Arg-Arg-Gly-Arg-Arg + H2O
(Gln)14-Arg-Arg-Gly-Arg-Arg + Gln-Gln-Gln
show the reaction diagram
-
little activity
-
-
?
(Gln)20-Arg-Arg-Gly-Arg-Arg + H2O
(Gln)17-Arg-Arg-Gly-Arg-Arg + Gln-Gln-Gln
show the reaction diagram
-
little activity
-
-
?
Ala-Ala-Ala + H2O
Ala + Ala-Ala
show the reaction diagram
26% of the activity with Met-Gly-Gly
-
?
Ala-Ala-Phe-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
-
-
-
?
Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
Ala-Ala-Phe + 7-amino-4-methylcoumarin
show the reaction diagram
Ala-Ala-Phe-p-nitroanilide + H2O
Ala-Ala-Phe + p-nitroaniline
show the reaction diagram
-
-
-
?
Ala-Phe-Pro-beta-naphthylamide + H2O
Ala-Phe-Pro + beta-naphthylamine
show the reaction diagram
angiotensin II + H2O
?
show the reaction diagram
-
-
-
-
?
angiotensin III + H2O
?
show the reaction diagram
-
-
-
-
?
Arg-Ala-Arg + H2O
Arg + Ala-Arg
show the reaction diagram
-
-
-
-
?
Arg-Ser-Arg + H2O
Arg + Ser-Arg
show the reaction diagram
-
-
-
-
?
casein + H2O
?
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
cholecystokinin octapeptide + H2O
?
show the reaction diagram
-
-
-
-
?
des-Tyr-dynorphin A1-8 + H2O
?
show the reaction diagram
-
-
-
-
?
enkephalin + H2O
?
show the reaction diagram
-
-
-
-
?
Gly-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + Gly
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
Gly-Ala-Pro-beta-naphthylamide + H2O
Gly-Ala-Pro + beta-naphthylamine
show the reaction diagram
Gly-Gly-Gly + H2O
Gly + Gly-Gly
show the reaction diagram
Gly-Gly-Phe + H2O
Gly + Gly-Phe
show the reaction diagram
Gly-Leu-Tyr + H2O
Gly + Leu-Tyr
show the reaction diagram
L-Ala-Gly-Gly + H2O
L-Ala + Gly-Gly
show the reaction diagram
-
-
-
-
?
L-Ala-L-Ala-D-Ala + H2O
L-Ala + L-Ala-D-Ala
show the reaction diagram
-
-
-
-
?
L-Ala-L-Ala-L-Ala + H2O
L-Ala + L-Ala-L-Ala
show the reaction diagram
L-Ala-L-Ala-L-Phe-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Ala-L-Ala-L-Phe
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Asp-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Asp
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Gln-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Gln
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Leu-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Leu
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Lys-4-nitroanilide + H2O
4-nitroaniline + L-Lys
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Met-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Met
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Met-L-Met-L-Met + H2O
L-Met + L-Met-L-Met
show the reaction diagram
L-Phe-Gly-Gly + H2O
L-Phe + Gly-Gly
show the reaction diagram
L-Pro-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Pro
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Pro-Gly-Gly + H2O
L-Pro + Gly-Gly
show the reaction diagram
-
-
-
-
?
L-Thr-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Thr
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Trp-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Trp
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Tyr-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Tyr
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
Leu-Gly-Gly + H2O
Leu + Gly-Gly
show the reaction diagram
Leu-Leu-Ala + H2O
Leu + Leu-Ala
show the reaction diagram
33% of the activity with Met-Gly-Gly
-
?
Leu-Leu-Leu + H2O
Leu + Leu-Leu
show the reaction diagram
15% of the activity with Met-Gly-Gly
-
?
Lys-Gly-Gly + H2O
Lys + Gly-Gly
show the reaction diagram
13% of the activity with Met-Gly-Gly
-
?
Met-Ala-Ser + H2O
?
show the reaction diagram
-
-
-
-
?
Met-Ala-Ser + H2O
Met + Ala-Ser
show the reaction diagram
-
-
-
?
Met-Gly-Gly + H2O
Met + Gly-Gly
show the reaction diagram
microcin C + H2O
?
show the reaction diagram
-
microcin C is processed to a nonhydrolyzable analog of aspartyl-adenylate
-
-
?
neurokinin alpha + H2O
?
show the reaction diagram
-
-
-
-
?
oxidized insulin B chain + H2O
?
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
Ser-Ser-Ser + H2O
?
show the reaction diagram
-
-
-
-
?
tripeptides + H2O
?
show the reaction diagram
-
e.g. Met-Leu-Tyr: chemotactic factor, Gly-His-Lys: liver growth factor, slow hydrolysis
-
-
?
Tyr-Gly-Gly + H2O
Tyr + Gly-Gly
show the reaction diagram
11% of the activity with Met-Gly-Gly
-
?
additional information
?
-