3.4.11.4: tripeptide aminopeptidase
This is an abbreviated version!
For detailed information about tripeptide aminopeptidase, go to the full flat file.
Word Map on EC 3.4.11.4
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3.4.11.4
-
tripeptides
-
proteasome
-
tripeptidyl-peptidase
-
dipeptidase
-
aminopeptidases
-
ceroid
-
caseinolytic
-
late-infantile
-
oligopeptidase
-
lipofuscinosis
-
cremoris
-
extralysosomal
-
channa
-
glycylglycine
- 3.4.11.4
- tripeptides
- proteasome
-
tripeptidyl-peptidase
- dipeptidase
- aminopeptidases
-
ceroid
-
caseinolytic
-
late-infantile
-
oligopeptidase
- lipofuscinosis
- cremoris
-
extralysosomal
-
channa
- glycylglycine
Reaction
release of the N-terminal residue from a tripeptide =
Synonyms
alanine-phenylalanine-proline arylamidase, alpha-aminoacyl-dipeptide hydrolase, aminoexotripeptidase, aminopeptidase, human liver, aminotripeptidase, arginyl tri-peptidase, ec 3.4.1.3, EC 3.4.14.10, imidoendopeptidase, lymphopeptidase, PepB, PepT, peptidase B, peptidase T, prolyl tripeptidyl aminopeptidase, PTP, PTP39, TPP I, TPP II, TPPII, tripeptidase, tripeptidyl aminopeptidase, tripeptidyl exopeptidase II, tripeptidyl peptidase II, tripeptidyl-peptidase I, tripeptidyl-peptidase II
ECTree
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Substrates Products
Substrates Products on EC 3.4.11.4 - tripeptide aminopeptidase
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REACTION DIAGRAM
(Gln)17-Arg-Arg-Gly-Arg-Arg + H2O
(Gln)14-Arg-Arg-Gly-Arg-Arg + Gln-Gln-Gln
-
little activity
-
-
?
(Gln)20-Arg-Arg-Gly-Arg-Arg + H2O
(Gln)17-Arg-Arg-Gly-Arg-Arg + Gln-Gln-Gln
-
little activity
-
-
?
Ala-Ala-Ala + H2O
Ala + Ala-Ala
26% of the activity with Met-Gly-Gly
-
?
Gly-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + Gly
-
assay at pH 8.0, 37°C
-
-
?
L-Ala-L-Ala-L-Phe-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Ala-L-Ala-L-Phe
-
assay at pH 8.0, 37°C
-
-
?
L-Asp-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Asp
-
assay at pH 8.0, 37°C
-
-
?
L-Gln-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Gln
-
assay at pH 8.0, 37°C
-
-
?
L-Leu-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Leu
-
assay at pH 8.0, 37°C
-
-
?
L-Lys-4-nitroanilide + H2O
4-nitroaniline + L-Lys
-
assay at pH 8.0, 37°C
-
-
?
L-Met-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Met
-
assay at pH 8.0, 37°C
-
-
?
L-Pro-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Pro
-
assay at pH 8.0, 37°C
-
-
?
L-Thr-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Thr
-
assay at pH 8.0, 37°C
-
-
?
L-Trp-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Trp
-
assay at pH 8.0, 37°C
-
-
?
L-Tyr-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Tyr
-
assay at pH 8.0, 37°C
-
-
?
Leu-Leu-Ala + H2O
Leu + Leu-Ala
33% of the activity with Met-Gly-Gly
-
?
Leu-Leu-Leu + H2O
Leu + Leu-Leu
15% of the activity with Met-Gly-Gly
-
?
Lys-Gly-Gly + H2O
Lys + Gly-Gly
13% of the activity with Met-Gly-Gly
-
?
microcin C + H2O
?
-
microcin C is processed to a nonhydrolyzable analog of aspartyl-adenylate
-
-
?
tripeptides + H2O
?
-
e.g. Met-Leu-Tyr: chemotactic factor, Gly-His-Lys: liver growth factor, slow hydrolysis
-
-
?
Tyr-Gly-Gly + H2O
Tyr + Gly-Gly
11% of the activity with Met-Gly-Gly
-
?
Ala-Ala-Phe + 7-amino-4-methylcoumarin
-
-
-
-
?
Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
Ala-Ala-Phe + 7-amino-4-methylcoumarin
-
-
-
-
?
Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
Ala-Ala-Phe + 7-amino-4-methylcoumarin
-
-
-
-
?
Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
Ala-Ala-Phe + 7-amino-4-methylcoumarin
-
-
-
-
?
Ala-Phe-Pro + beta-naphthylamine
-
-
-
-
?
Ala-Phe-Pro-beta-naphthylamide + H2O
Ala-Phe-Pro + beta-naphthylamine
-
-
-
-
?
Gly-Ala-Pro + beta-naphthylamine
-
-
-
-
?
Gly-Ala-Pro-beta-naphthylamide + H2O
Gly-Ala-Pro + beta-naphthylamine
-
-
-
-
?
Gly-Leu-Tyr + H2O
Gly + Leu-Tyr
15% of the activity with Met-Gly-Gly
-
?
Leu-Gly-Gly + H2O
Leu + Gly-Gly
34% of the activity with Met-Gly-Gly
-
?
Leu-Gly-Gly + H2O
Leu + Gly-Gly
-
Leu can be replaced by Ala, Phe, Gly-Pro
-
-
?
Leu-Gly-Gly + H2O
Leu + Gly-Gly
-
Leu can be replaced by Phe and Trp
-
-
?
Leu-Gly-Gly + H2O
Leu + Gly-Gly
-
Leu can be replaced by Ala, Phe, Gly-Pro
-
-
?
Leu-Gly-Gly + H2O
Leu + Gly-Gly
-
Leu can be replaced by Ala, Phe, Gly-Pro
-
?
?
-
-
the enzyme digests peptide products of the 26S proteasome and other endopeptidases into tripeptides
-
-
?
additional information
?
-
-
no digestion is observed against Lys-Lys-(Gln)30-Lys-Lys
-
-
?
additional information
?
-
-
no activity with Gly-Pro-beta-naphthylamide, Z-Gly-Pro-beta-naphthylamide, Z-Gly-Ala-Pro-beta-naphthylamide, Z-Ala-Gly-Pro-beta-naphthylamide, Gly-Ala-Gly-Pro-beta-naphthylamide, Z-Gly-Ala-Gly-Pro-beta-naphthylamide, and Ala-Gly-Ala-Gly-Pro-beta-naphthylamide
-
-
?