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3.4.11.4: tripeptide aminopeptidase

This is an abbreviated version!
For detailed information about tripeptide aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.4

Reaction

release of the N-terminal residue from a tripeptide =

Synonyms

alanine-phenylalanine-proline arylamidase, alpha-aminoacyl-dipeptide hydrolase, aminoexotripeptidase, aminopeptidase, human liver, aminotripeptidase, arginyl tri-peptidase, ec 3.4.1.3, EC 3.4.14.10, imidoendopeptidase, lymphopeptidase, PepB, PepT, peptidase B, peptidase T, prolyl tripeptidyl aminopeptidase, PTP, PTP39, TPP I, TPP II, TPPII, tripeptidase, tripeptidyl aminopeptidase, tripeptidyl exopeptidase II, tripeptidyl peptidase II, tripeptidyl-peptidase I, tripeptidyl-peptidase II

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.4 tripeptide aminopeptidase

Inhibitors

Inhibitors on EC 3.4.11.4 - tripeptide aminopeptidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
2,5-diamino-8-carbamimidamido-N-(4,8-diamino-5-methyl-1-methylidene-2,3,7-trioxononyl)-4-oxooctanamide
-
potent inhibitor
2-mercaptoethanol
5,5'-dithiobis(2-nitrobenzoate)
-
-
5-5'-dithiobis(2-nitrobenzoic acid)
-
-
Ala-Ala-Phe chloromethyl ketone
-
-
Ala-Ala-Phe-chloromethyl ketone
-
85-90% inhibition at 1 mM
Ala-Ala-Phe-chloromethylketone
Ala-Ile-pyrrolidin-2-yl boronic acid
-
-
Amino aldehydes
-
e.g. leucinal, prolinal, alaninal
antipain
-
-
bacitracin
-
-
bestatin
butabindide
Carboxy-o-phenanthroline
-
-
chymostatin
-
-
D-3-thio-2-methylpropanyl proline
-
-
diisopropylfluorophosphate
-
strongly inhibitory at 1 mM
dithiothreitol
iodoacetate
-
-
iodoacetic acid
-
partial inhibition at 1 mM
L-Leu-Gly-Gly
-
substrate inhibition
Met-enkephalin
-
-
Met-Leu-Tyr
-
-
molybdate
-
-
N-ethylmaleimide
o-phenanthroline
-
-
O3-tertiary-butyl-threonylphenylalanylproline
-
-
p-chloromercuribenzoate
-
-
p-chloromercuriphenyl sulfonic acid
-
-
p-chloromercuriphenylsulfonic acid
-
strongly inhibitory at 1 mM
p-hydroxymercuribenzoate
p-Hydroxymercuriphenyl sulfonate
-
-
pepstatin
Phenylmethanesulfonylfluoride
-
-
phenylmethylsulfonyl fluoride
0.1 mM, 89% inhibition
puromycin
-
-
tosyl-L-lysine-chloromethylketone
-
-
tosyl-phenylalanine-chloromethylketone
-
-
Tripeptides with Pro in N-terminal position
-
-
Z-Gly-Leu-Ala-OH