3.4.11.25: beta-peptidyl aminopeptidase

This is an abbreviated version, for detailed information about beta-peptidyl aminopeptidase, go to the full flat file.

Reaction

cleaves N-terminal beta-homoamino acids from peptides composed of 2 to 6 amino acids =

Synonyms

3-2W4 BapA, BapF, PA1486, Y2 BapA

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.25 beta-peptidyl aminopeptidase

Substrates Products

Substrates Products on EC 3.4.11.25 - beta-peptidyl aminopeptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(beta-homoAla-beta-homoLys-beta-homoPhe)2 + H2O
beta-homoAla + beta-homoLys + beta-homoPhe
show the reaction diagram
2 beta-homoGly 4-nitroanilide
beta-homoGly-beta-homoGly 4-nitroanilide + 4-nitroaniline
show the reaction diagram
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product of mutant S237C, synthesized efficiently without degradation
-
?
beta-Ala-Ile-beta-homoTyr + H2O
beta-Ala + Ile-beta-homoTyr
show the reaction diagram
beta-Ala-L-His + H2O
beta-Ala + L-His
show the reaction diagram
beta-Ala-p-nitroanilide + H2O
beta-Ala + p-nitroaniline
show the reaction diagram
beta-homoAla-beta-homoLeu + H2O
beta-homoAla + beta-homoLeu
show the reaction diagram
beta-homoAla-beta-homoLeu + H2O
beta-homoAla-beta-homoLeu
show the reaction diagram
beta-homoAla-p-nitroanilide + H2O
beta-homoAla + p-nitroaniline
show the reaction diagram
beta-homoArg-Ile-beta-homoTyr + H2O
beta-homoArg + Ile-beta-homoTyr
show the reaction diagram
beta-homoGln-Ile-beta-homoTyr + H2O
beta-homoGln + Ile-beta-homoTyr
show the reaction diagram
beta-homoGly 4-nitroanilide + H2O
beta-homoGly + 4-nitroaniline
show the reaction diagram
-
wild-type enzyme shows beta-homoGly-beta-homoGly-4-nitroanilide synthetic activity, but the product vanishes in a few min and converts to free beta-homoGly
-
?
beta-homoHis-Ile-beta-homoTyr + H2O
beta-homoHis + Ile-beta-homoTyr
show the reaction diagram
beta-homoHis-Ile-beta-homoTyr + H2O
beta-homoHis-Ile-beta-homoTyr
show the reaction diagram
beta-homoLeu-Ile-beta-homoTyr + H2O
beta-homoLeu + Ile-beta-homoTyr
show the reaction diagram
beta-homoLys-Ile-beta-homoTyr + H2O
beta-homoLys + Ile-beta-homoTyr
show the reaction diagram
beta-homoPhe-Ile-beta-homoTyr + H2O
beta-homoPhe + Ile-beta-homoTyr
show the reaction diagram
beta-homoPhe-p-nitroanilide + H2O
beta-homoPhe + p-nitroaniline
show the reaction diagram
beta-homoSer-Ile-beta-homoTyr + H2O
beta-homoSer + Ile-beta-homoTyr
show the reaction diagram
beta-homoThr-Ile-beta-homoTyr + H2O
beta-homoThr + Ile-beta-homoTyr
show the reaction diagram
beta-homoTrp-Ile-beta-homoTyr + H2O
beta-homoTrp + Ile-beta-homoTyr
show the reaction diagram
beta-homoTyr-Ile-beta-homoTyr + H2O
beta-homoTyr + Ile-beta-homoTyr
show the reaction diagram
beta-homoVal-beta-homoAla-beta-homoLeu + H2O
beta-homoVal + beta-homoAla-beta-homoLeu
show the reaction diagram
beta-homoVal-beta-homoArg-beta-homoArg + H2O
beta-homoVal + beta-homoArg-beta-homoArg
show the reaction diagram
beta-homoVal-beta-homoIle-beta-homoTyr + H2O
beta-homoVal + beta-homoIle + beta-homoTyr
show the reaction diagram
beta-homoVal-beta-homoIle-Tyr + H2O
beta-homoVal + beta-homoIle + Tyr
show the reaction diagram
beta-homoVal-Ile-beta-homoTyr + H2O
beta-homoVal + Ile-beta-homoTyr
show the reaction diagram
beta-homoVal-Ile-Tyr + H2O
beta-homoVal + Ile-Tyr
show the reaction diagram
only the N-terminal beta-homoVal is released. Hydrolysis at 32% compared to hydrolysis of beta-homoAla-beta-homoLeu
-
-
?
D-beta-homoVal-Ile-beta-homoTyr + H2O
D-beta-homoVal + Ile-beta-homoTyr
show the reaction diagram
Val-Ile-Tyr + H2O
beta-homoVal + Ile-Tyr
show the reaction diagram
only the N-terminal beta-homoVal is released. Preferred substrate
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-
?
additional information
?
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