3.4.11.23: PepB aminopeptidase
This is an abbreviated version!
For detailed information about PepB aminopeptidase, go to the full flat file.
Reaction
release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln =
Synonyms
aminopeptidase, tripeptide, PepB, peptidase pepB, Salmonella enterica serovar Typhimurium peptidase B
ECTree
3.4.11.23 PepB aminopeptidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.11.23 - PepB aminopeptidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Asp-Ile + H2O
Asp + Ile
-
best substrate, 120% activity compared to substrate Asp-Leu
-
?
Asp-Leu-Gly + H2O
Asp + Leu-Gly
-
higher activity compared to substrate Asp-Leu
-
?
Asp-Phe + H2O
Asp + Phe
-
105% activity compared to substrate Asp-Leu
-
?
Asp-Xaa + H2O
Asp + Xaa
-
Xaa is an amino acid, substrate specificity, overview
-
?
DL-beta-methoxy-alpha-amino propionamide + H2O
O-methyl-L-serine + NH3
-
-
-
?
Gln-Leu + H2O
Gln + Leu
-
9% activity compared to substrate Asp-Leu
-
?
Ile-Leu + H2O
Ile + Leu
-
2% activity compared to substrate Asp-Leu
-
?
O-benzoyl-DL-serinamide + H2O
O-benzoyl-L-serine + NH3
-
72% of the activity with DL-beta-methoxy-alpha-amino propionamide, 98.1% enantiomeric excess
-
-
?
O-butyl-DL-serinamide + H2O
O-butyl-L-serine + NH3
-
51% of the activity with DL-beta-methoxy-alpha-amino propionamide, 96.2% enantiomeric excess
-
-
?
O-ethyl-DL-serinamide + H2O
O-ethyl-L-serine + NH3
-
83% of the activity with DL-beta-methoxy-alpha-amino propionamide, 98.3% enantiomeric excess
-
-
?
O-isopropyl-DL-serinamide + H2O
O-isopropyl-L-serine + NH3
-
60% of the activity with DL-beta-methoxy-alpha-amino propionamide, 97.1% enantiomeric excess
-
-
?
O-methyl-DL-serinamide + H2O
O-methyl-L-serine + NH3
-
-
99.1% enantiomeric excess
-
?
O-propyl-DL-serinamide + H2O
O-propyl-L-serine + NH3
-
65% of the activity with DL-beta-methoxy-alpha-amino propionamide, 98.5% enantiomeric excess
-
-
?
O-tert-butyl-DL-serinamide + H2O
O-tert-butyl-L-serine + NH3
-
45% of the activity with DL-beta-methoxy-alpha-amino propionamide, 94.3% enantiomeric excess
-
-
?
Phe-Leu + H2O
Phe + Leu
-
7% activity compared to substrate Asp-Leu
-
?
Trp-Leu + H2O
Trp + Leu
-
4% activity compared to substrate Asp-Leu
-
?
Tyr-Leu + H2O
Tyr + Leu
-
6% activity compared to substrate Asp-Leu
-
?
Val-Leu + H2O
Val + Leu
-
2% activity compared to substrate Asp-Leu
-
?
Xaa-Leu + H2O
Xaa + Leu
-
Xaa is an amino acid, substrate specificity, overview
-
?
Ala-Leu + H2O
Ala + Leu
-
-
-
?
Ala-Leu + H2O
Ala + Leu
-
3% activity compared to substrate Asp-Leu
-
?
Asn-Leu + H2O
Asn + Leu
-
-
-
?
Asn-Leu + H2O
Asn + Leu
-
23% activity compared to substrate Asp-Leu
-
?
Asp-Leu + H2O
Asp + Leu
-
-
-
?
Asp-Leu + H2O
Asp + Leu
-
best substrate
-
?
Cys-Leu + H2O
Cys + Leu
-
-
-
?
Cys-Leu + H2O
Cys + Leu
-
23% activity compared to substrate Asp-Leu
-
?
Glu-Leu + H2O
Glu + Leu
-
-
-
?
Glu-Leu + H2O
Glu + Leu
-
74% activity compared to substrate Asp-Leu
-
?
His-Leu + H2O
His + Leu
-
-
-
?
His-Leu + H2O
His + Leu
-
28% activity compared to substrate Asp-Leu
-
?
Leu-Cys + H2O
Leu + Cys
-
-
-
?
Leu-Cys + H2O
Leu + Cys
-
24% activity compared to substrate Asp-Leu
-
?
Leu-His + H2O
Leu + His
-
-
-
?
Leu-His + H2O
Leu + His
-
9% activity compared to substrate Asp-Leu
-
?
Leu-Ile + H2O
Leu + Ile
-
-
-
?
Leu-Ile + H2O
Leu + Ile
-
59% activity compared to substrate Asp-Leu
-
?
Leu-Leu + H2O
Leu + Leu
-
-
-
?
Leu-Leu + H2O
Leu + Leu
-
40% activity compared to substrate Asp-Leu
-
?
Leu-Met + H2O
Leu + Met
-
-
-
?
Leu-Met + H2O
Leu + Met
-
30% activity compared to substrate Asp-Leu
-
?
Leu-Phe + H2O
Leu + Phe
-
-
-
?
Leu-Phe + H2O
Leu + Phe
-
12% activity compared to substrate Asp-Leu
-
?
Leu-Tyr + H2O
Leu + Tyr
-
-
-
?
Leu-Tyr + H2O
Leu + Tyr
-
37% activity compared to substrate Asp-Leu
-
?
Leu-Xaa + H2O
Leu + Xaa
-
Xaa is an amino acid, substrate specificity, overview
-
?
Leu-Xaa + H2O
Leu + Xaa
-
lower activity compared to substrate Asp-Leu
-
?
Met-Leu + H2O
Met + Leu
-
-
-
?
Met-Leu + H2O
Met + Leu
-
30% activity compared to substrate Asp-Leu
-
?
Ser-Leu + H2O
Ser + Leu
-
-
-
?
Ser-Leu + H2O
Ser + Leu
-
2% activity compared to substrate Asp-Leu
-
?
Thr-Leu + H2O
Thr + Leu
-
-
-
?
Thr-Leu + H2O
Thr + Leu
-
3% activity compared to substrate Asp-Leu
-
?
Xaa-Gly-Gly + H2O
Xaa + Gly-Gly
-
Xaa is an amino acid, substrate specificity, overview
-
?
Xaa-Gly-Gly + H2O
Xaa + Gly-Gly
-
low activity compared to substrate Asp-Leu
-
?
Xaa-peptide + H2O
Xaa + peptide
-
substrate specificity, overview
-
?
Xaa-peptide + H2O
Xaa + peptide
-
Xaa is an amino acid
-
?
