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3.4.11.14: cytosol alanyl aminopeptidase

This is an abbreviated version!
For detailed information about cytosol alanyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.14

Reaction

release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides =

Synonyms

AAP, AAP-S, AlaAP, alanyl aminopeptidase, alanyl-aminopeptidase, alanyl-AP, aminopeptidase M, aminopeptidase N, aminopeptidase, cytosol alanyl, Aminopolypeptidase, aminotripeptidase, angiotensinase M, Arg-AP, cytyosol aminopeptidase III, GenePSA-dependent puromycin-sensitive aminopeptidase, mAAP, microsomal alanyl aminopeptidase, MP100, NAP, neutral aminopeptidase, NPEPPS, nucleomorphin, PAM-1, PSA, PSA/NPEPPS, puromycin-sensitive aminopeptidase, puromycin-sensitive aminopeptidasePSA/NPEPPS, puromycin-sensitive neuron-aminopeptidase, soluble alanyl aminopeptidase, tripeptidase, tripeptide aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.14 cytosol alanyl aminopeptidase

KM Value

KM Value on EC 3.4.11.14 - cytosol alanyl aminopeptidase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.123
Ala-2-naphthylamide
-
-
0.235
Ala-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.27
Ala-p-nitroanilide
-
with 1 mM dithiothreitol, in 10 mM Tris-HCl, pH 7.4, at 37°C
0.054
Arg-2-naphthylamide
-
-
0.03
Arg-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.24
glycine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
0.048
Ile-naphthylamide
-
-
0.035
L-alanine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
0.0013
L-arginine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
0.0019
L-leucine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
0.0052
L-lysine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
0.01
L-methionine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
0.0066
L-proline-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
0.045
L-tyrosine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
0.0033
L-valine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
0.071
Leu-2-naphthylamide
-
-
0.22
Leu-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.25
Leu-p-nitroanilide
-
with 1 mM dithiothreitol, in 10 mM Tris-HCl, pH 7.4, at 37°C
0.04
Lys-2-naphthylamide
-
-
0.115
Lys-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.11
Lys-Ala-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
2.2
Lys-p-nitroanilide
-
with 1 mM dithiothreitol, in 10 mM Tris-HCl, pH 7.4, at 37°C
0.014
Met-2-naphthylamide
-
-
0.115
Met-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.00095
Met-enkephalin
-
-
0.8
Met-p-nitroanilide
-
with 1 mM dithiothreitol, in 10 mM Tris-HCl, pH 7.4, at 37°C
0.142
Phe-2-naphthylamide
-
-
0.26
Phe-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.5
Pro-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.47
Pro-p-nitroanilide
-
with 1 mM dithiothreitol, in 10 mM Tris-HCl, pH 7.4, at 37°C
0.02
Pro-Phe-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.17
Tyr-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.042
Val-2-naphthylamide
-
-
0.21
Val-p-nitroanilide
-
with 1 mM dithiothreitol, in 10 mM Tris-HCl, pH 7.4, at 37°C