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3.4.11.14: cytosol alanyl aminopeptidase

This is an abbreviated version!
For detailed information about cytosol alanyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.14

Reaction

release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides =

Synonyms

AAP, AAP-S, AlaAP, alanyl aminopeptidase, alanyl-aminopeptidase, alanyl-AP, aminopeptidase M, aminopeptidase N, aminopeptidase, cytosol alanyl, Aminopolypeptidase, aminotripeptidase, angiotensinase M, Arg-AP, cytyosol aminopeptidase III, GenePSA-dependent puromycin-sensitive aminopeptidase, mAAP, microsomal alanyl aminopeptidase, MP100, NAP, neutral aminopeptidase, NPEPPS, nucleomorphin, PAM-1, PSA, PSA/NPEPPS, puromycin-sensitive aminopeptidase, puromycin-sensitive aminopeptidasePSA/NPEPPS, puromycin-sensitive neuron-aminopeptidase, soluble alanyl aminopeptidase, tripeptidase, tripeptide aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.14 cytosol alanyl aminopeptidase

Turnover Number

Turnover Number on EC 3.4.11.14 - cytosol alanyl aminopeptidase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
141
Ala-2-naphthylamide
-
-
13.1
Ala-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
3.8 - 20.83
Ala-p-nitroanilide
22.2
Arg-2-naphthylamide
-
-
0.13
Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.11
Arg-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
10.3
glycine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
6.33
Ile-2-naphthylamide
-
-
48.9
L-alanine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
3.8
L-arginine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
8.2
L-leucine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
17.1
L-lysine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
25.6
L-methionine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
1.1
L-proline-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
38.5
L-tyrosine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
0.9
L-valine-4-methylcoumaryl-7-amide
-
pH 7.0, 37°C
49.5
Leu-2-naphthylamide
-
-
11.3
Leu-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
3.5 - 19.83
Leu-p-nitroanilide
11.3
Lys-2-naphthylamide
-
-
19.5
Lys-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
4.5
Lys-Ala-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
89
Lys-p-nitroanilide
-
with 1 mM dithiothreitol, in 10 mM Tris-HCl, pH 7.4, at 37°C
95.5
Met-2-naphthylamide
-
-
14.3
Met-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
30
Met-p-nitroanilide
-
with 1 mM dithiothreitol, in 10 mM Tris-HCl, pH 7.4, at 37°C
74.5
Phe-2-naphthylamide
-
-
12.8
Phe-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
1.5
Pro-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
16.9 - 23.17
Pro-p-nitroanilide
0.97
Pro-Phe-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
7.7
Tyr-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
3.83
Val-2-naphthylamide
-
-
1.43
Val-p-nitroanilide
-
with 1 mM dithiothreitol, in 10 mM Tris-HCl, pH 7.4, at 37°C