3.4.11.10: bacterial leucyl aminopeptidase

This is an abbreviated version!
For detailed information about bacterial leucyl aminopeptidase, go to the full flat file.

Reaction

release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids =

Synonyms

AAP, Aeromonas proteolytica aminopeptidase, Aminopeptidase, aminopeptidase A, aminopeptidase A (bacteria), aminopeptidase Ap1, aminopeptidase II, AP-II, API, APII, AVP, bacterial leucine aminopeptidase, bacterial M17 aminopeptidase, BSAP, Bsu aminopeptidase, BsuAP, CGase, cysteinylglycinase, double-zinc aminopeptidase, extracellular aminopeptidase, FgLAP, HpM17AP, LAP, LAPII, leucine aminopeptidase, leucine aminopeptidase II, leucine APN, Leucyl aminopeptidase, M17 aminopeptidase, M17 metallo-aminopeptidase, More, MtLAP, PepA, Peptidase A, pepZ, PhpA, ribosomal-bound aminopeptidase, rLAP55, Rv2213, SSAP, TAP, TH-2, thermophilic aminopeptidase, thermostable leucine aminopeptidase, Vibrio aminopeptidase, VpAP, ywaD

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.11 Aminopeptidases

                3.4.11.10 bacterial leucyl aminopeptidase

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Results	in table
4	Activating Compound
28139	AA Sequence
8	Application
1	CAS Registry Number
32	Cloned(Commentary)
18	Crystallization (Commentary)
10	General Information
4	General Stability
17	IC50 Value
203	Inhibitors
8	kcat/KM [mM/s]
73	Ki Value [mM]
135	KM Value [mM]
25	Localization
103	Metals/Ions
51	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
98	Organism
1	Oxidation Stability
46	PDB ID
38	pH Optimum
7	pH Range
7	pH Stability
5	Posttranslational Modification
49	Protein Variants
43	Purification (Commentary)
17	Reaction
5	Reaction Type
95	Reference
2	Renatured (Commentary)
2	Source Tissue
84	Specific Activity [micromol/min/mg]
4	Storage Stability
255	Substrates and Products (Substrate)
38	Subunits
155	Synonyms
32	Temperature Optimum [°C]
2	Temperature Range [°C]
21	Temperature Stability [°C]
128	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.4.11.10 - bacterial leucyl aminopeptidase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2-mercaptoethanol

Escherichia coli

-

activates, 30% activation at 17 mM

81192

bicarbonate

Escherichia coli

-

activates

665072

dithiothreitol

Escherichia coli

-

activates, 23% activation at 0.021 mM, inhibition above

81192

additional information

Pseudomonas aeruginosa

-

full-length LAP is activated in a two-step process: proteolytic cleavage at the C terminus is followed by an intramolecular autocatalytic removal of a 12-amino acid propeptide at the N terminus

698878

-