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3.4.11.10: bacterial leucyl aminopeptidase

This is an abbreviated version!
For detailed information about bacterial leucyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.10

Reaction

release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids =

Synonyms

AAP, Aeromonas proteolytica aminopeptidase, Aminopeptidase, aminopeptidase A, aminopeptidase A (bacteria), aminopeptidase Ap1, aminopeptidase II, AP-II, API, APII, AVP, bacterial leucine aminopeptidase, bacterial M17 aminopeptidase, BSAP, Bsu aminopeptidase, BsuAP, CGase, cysteinylglycinase, double-zinc aminopeptidase, extracellular aminopeptidase, FgLAP, HpM17AP, LAP, LAPII, leucine aminopeptidase, leucine aminopeptidase II, leucine APN, Leucyl aminopeptidase, M17 aminopeptidase, M17 metallo-aminopeptidase, More, MtLAP, PepA, Peptidase A, pepZ, PhpA, ribosomal-bound aminopeptidase, rLAP55, Rv2213, SSAP, TAP, TH-2, thermophilic aminopeptidase, thermostable leucine aminopeptidase, Vibrio aminopeptidase, VpAP, ywaD

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.10 bacterial leucyl aminopeptidase

Substrates Products

Substrates Products on EC 3.4.11.10 - bacterial leucyl aminopeptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ala-Gly + H2O
Ala + Gly
show the reaction diagram
-
-
-
ir
albomycin + H2O
?
show the reaction diagram
Arg-4-nitroanilide + H2O
Arg + 4-nitroaniline
show the reaction diagram
Arg-Phe + H2O
Arg + Phe
show the reaction diagram
-
-
-
ir
casein + H2O
?
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
Cys-Gly + H2O
Cys + Gly
show the reaction diagram
Cys-Gly + H2O
L-Cys + Gly
show the reaction diagram
-
preferred substrate
-
-
?
DL-Ala-Gly-Gly + H2O
DL-Ala + Gly-Gly
show the reaction diagram
-
-
-
ir
DL-Leu-Gly-DL-Phe + H2O
DL-Leu + Gly-DL-Phe
show the reaction diagram
-
-
-
ir
DL-Leu-Gly-Gly + H2O
DL-Leu + Gly-Gly
show the reaction diagram
-
-
-
ir
Glu-Phe + H2O
Glu + Phe
show the reaction diagram
-
-
-
ir
glutathione + H2O
?
show the reaction diagram
-
the enzyme is involved in turnover of glutathione
-
-
?
Gly-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Gly
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
Gly-7-amido-4-methylcoumarin + H2O
Gly + 7-amino-4-methylcoumarin
show the reaction diagram
-
very weak activity
-
-
?
Ile-amide + H2O
Ile + NH3
show the reaction diagram
-
-
-
ir
Ile-Phe + H2O
Ile + Phe
show the reaction diagram
-
-
-
ir
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
show the reaction diagram
low activity
-
-
?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Ala-L-Ala-L-Phe-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Ala-L-Ala-L-Phe
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Ala-p-nitroanilide + H2O
L-Ala + p-nitroaniline
show the reaction diagram
-
1% activity compared to L-Leu-p-nitroanilide
-
-
?
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
show the reaction diagram
L-Arg-7-amido-4-methylcoumarin + H2O
L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
L-Arg-p-nitroanilide + H2O
L-Arg + p-nitroaniline
show the reaction diagram
-
3% activity compared to L-Leu-p-nitroanilide
-
-
?
L-arginyl 7-amido-4-carbamoylmethylcoumarin + H2O
L-arginine + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
L-Asp-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Asp
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Asp-7-amido-4-methylcoumarin + H2O
L-Asp + 7-amino-4-methylcoumarin
show the reaction diagram
L-Cys-4-nitroanilide + H2O
L-Cys + 4-nitroaniline
show the reaction diagram
L-Cys-7-amido-4-methylcoumarin + H2O
L-Cys + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-cysteinyl 7-amido-4-carbamoylmethylcoumarin + H2O
L-cysteine + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
L-cystinyl-p-nitroanilide + H2O
L-cystine + p-nitroaniline
show the reaction diagram
-
10% activity compared to L-Leu-p-nitroanilide
-
-
?
L-Gln-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Gln
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Glu-7-amido-4-methylcoumarin + H2O
L-Glu + 7-amino-4-methylcoumarin
show the reaction diagram
-
very weak activity
-
-
?
L-Ile-7-amido-4-methylcoumarin + H2O
L-Ile + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
show the reaction diagram
L-Leu-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Leu
show the reaction diagram
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
show the reaction diagram
L-Leu-Gly-Gly + H2O
L-Leu + Gly-Gly
show the reaction diagram
L-Leu-p-nitroanilide + H2O
L-Leu + p-nitroaniline
show the reaction diagram
L-leucine 4-nitroanilide + H2O
L-leucine + 4-nitroaniline
show the reaction diagram
L-leucine anilide + H2O
L-leucine + aniline
show the reaction diagram
-
-
-
?
L-leucine ethyl ester + H2O
L-leucine + ethanol
show the reaction diagram
-
-
-
?
L-leucine-4-anisidide + H2O
L-leucine + anisidine
show the reaction diagram
-
-
-
?
L-leucine-4-nitroanilide + H2O
L-leucine + 4-nitroaniline
show the reaction diagram
L-leucine-p-nitroanilide + H2O
L-Leu + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-leucyl 7-amido-4-carbamoylmethylcoumarin + H2O
L-leucine + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
L-leucyl-4-nitroanilide + H2O
L-leucine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-leucyl-L-leucyl-L-leucine + H2O
L-leucine + L-leucyl-L-leucine
show the reaction diagram
-
-
-
?
L-Lys-4-nitroanilide + H2O
4-nitroaniline + L-Lys
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Lys-4-nitroanilide + H2O
L-Lys + 4-nitroaniline
show the reaction diagram
-
-
-
?
L-Lys-p-nitroanilide + H2O
L-Lys + p-nitroaniline
show the reaction diagram
-
24% activity compared to L-Leu-p-nitroanilide
-
-
?
L-Met-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Met
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Met-7-amido-4-methylcoumarin + H2O
L-Met + 7-amino-4-methylcoumarin
show the reaction diagram
L-methionyl 7-amido-4-carbamoylmethylcoumarin + H2O
L-methionine + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
L-Phe-7-amido-4-methylcoumarin + H2O
L-Phe + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Phe-p-nitroanilide + H2O
L-Phe + p-nitroaniline
show the reaction diagram
-
23% activity compared to L-Leu-p-nitroanilide
-
-
?
L-Pro-4-nitroanilide + H2O
L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Pro-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Pro
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Pro-7-amido-4-methylcoumarin + H2O
L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
L-Ser-7-amido-4-methylcoumarin + H2O
L-Ser + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Thr-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Thr
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Thr-7-amido-4-methylcoumarin + H2O
L-Thr + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Trp-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Trp
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Tyr-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Tyr
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
L-Tyr-7-amido-4-methylcoumarin + H2O
L-Tyr + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Val-4-nitroanilide + H2O
L-Val + 4-nitroaniline
show the reaction diagram
low activity
-
-
?
L-Val-7-amido-4-methylcoumarin + H2O
L-Val + 7-amino-4-methylcoumarin
show the reaction diagram
-
very weak activity
-
-
?
L-Val-L-Phe + H2O
L-Val + L-Phe
show the reaction diagram
-
-
-
-
?
Leu-4-nitroanilide + H2O
Leu + 4-nitroaniline
show the reaction diagram
Leu-Ala + H2O
Leu + Ala
show the reaction diagram
Leu-amide + H2O
Leu + NH3
show the reaction diagram
Leu-Arg + H2O
Leu + Arg
show the reaction diagram
Leu-beta-naphthylamide + H2O
Leu + beta-naphthylamine
show the reaction diagram
Leu-Gly + H2O
Leu + Gly
show the reaction diagram
-
-
-
ir
Leu-Ile + H2O
Leu + Ile
show the reaction diagram
Leu-Leu + H2O
Leu + Leu
show the reaction diagram
Leu-Met + H2O
Leu + Met
show the reaction diagram
Leu-methyl ester + H2O
Leu + methanol
show the reaction diagram
-
-
-
ir
Leu-Phe + H2O
Leu + Phe
show the reaction diagram
Leu-Trp + H2O
Leu + Trp
show the reaction diagram
Leu-Tyr + H2O
Leu + Tyr
show the reaction diagram
Leu-Val + H2O
Leu + Val
show the reaction diagram
leucine-4-nitroaniline + H2O
?
show the reaction diagram
-
enzyme also shows activity towards Arg-4-nitroaniline, Lys-4-nitroaniline and Met-4-nitroaniline
-
-
?
Lys-4-nitroanilide + H2O
Lys + 4-nitroaniline
show the reaction diagram
Lys-Gly + H2O
Lys + Gly
show the reaction diagram
-
-
-
ir
Met-4-nitroanilide + H2O
Met + 4-nitroaniline
show the reaction diagram
Met-amide + H2O
Met + NH3
show the reaction diagram
-
-
-
ir
Met-beta-naphthylamide + H2O
Met + beta-naphthylamine
show the reaction diagram
-
-
-
ir
Met-Leu-4-nitroanilide + H2O
Met-Leu + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Met-Leu-7-amido-4-methylcoumarin + H2O
Met-Leu + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Met-Phe + H2O
Met + Phe
show the reaction diagram
-
-
-
ir
norleucinamide + H2O
norleucine + NH3
show the reaction diagram
norvalinamide + H2O
norvaline + NH3
show the reaction diagram
-
-
-
-
?
oxidized insulin B chain + H2O
?
show the reaction diagram
-
assay at pH 8.0, 37°C
-
-
?
Peptides + H2O
?
show the reaction diagram
peptides + H2O
N-terminal amino acid + peptide(n-1)
show the reaction diagram
-
-
-
?
Phe-amide + H2O
Phe + NH3
show the reaction diagram
-
-
-
ir
Phe-Asp-Ser-Ala-Val + H2O
Phe + Asp-Ser-Ala-Val
show the reaction diagram
-
-
-
ir
Phe-beta-naphthylamide + H2O
Phe + beta-naphthylamine
show the reaction diagram
Phe-Gly + H2O
Phe + Gly
show the reaction diagram
-
-
-
ir
Phe-methyl ester + H2O
Phe + methanol
show the reaction diagram
-
-
-
ir
Phe-Phe + H2O
Phe + Phe
show the reaction diagram
-
-
-
ir
Pro-Phe-Gly-Lys + H2O
Pro + Phe-Gly-Lys
show the reaction diagram
-
-
-
ir
Pro-Phe-Pro + H2O
Pro + Phe-Pro
show the reaction diagram
-
-
-
ir
recombinant human methionine-interferon alpha-2b + H2O
L-methionine + recombinant human interferon alpha-2b
show the reaction diagram
-
-
-
?
thionoleucine-4-anisidide + H2O
thionoleucine + anisidine
show the reaction diagram
-
-
-
?
thionoleucine-S-anilide + H2O
thionoleucine + aniline
show the reaction diagram
-
-
-
?
Thr-beta-naphthylamide + H2O
Thr + beta-naphthylamine
show the reaction diagram
-
3.3% of rate of hydrolysis of Leu-beta-naphthylamide
-
ir
Tyr-Gly + H2O
Tyr + Gly
show the reaction diagram
-
-
-
ir
Val-amide + H2O
Val + NH3
show the reaction diagram
-
-
-
ir
Val-beta-naphthylamide + H2O
Val + beta-naphthylamine
show the reaction diagram
-
-
-
ir
Val-Gly + H2O
Val + Gly
show the reaction diagram
-
-
-
ir
additional information
?
-