3.3.2.1: isochorismatase

This is an abbreviated version!
For detailed information about isochorismatase, go to the full flat file.

Reaction

Synonyms

2,3 dihydro-2,3 dihydroxybenzoate synthase, 2,3-dihydro-2,3-dihydroxybenzoate synthase, 2,3-dihydroxy-2,3-dihydrobenzoate synthase, 2,3-dihydroxy-2,3-dihydrobenzoic synthase, AngB, AngB-ISC, EntB, IHL, IPL, ISC, ISOC2, isochorismatase, isochorismatase domain containing 2, isochorismatase hydrolase, isochorismate lyase, Mhpg, PchB, SOI1, VabB, VabB-ISC

ECTree

     3 Hydrolases

         3.3 Acting on ether bonds

             3.3.2 Ether hydrolases

                3.3.2.1 isochorismatase

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Results	in table
4481	AA Sequence
1	Application
1	CAS Registry Number
9	Cloned(Commentary)
7	Crystallization (Commentary)
19	Disease/ Diagnostics
8	General Information
2	IC50 Value
6	Inhibitors
2	Ki Value [mM]
9	KM Value [mM]
2	Localization
11	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
25	Organism
5	Pathway
8	PDB ID
2	pH Optimum
1	pH Stability
28	Protein Variants
5	Purification (Commentary)
5	Reaction
3	Reaction Type
22	Reference
6	Source Tissue
1	Storage Stability
23	Substrates and Products (Substrate)
15	Subunits
51	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
12	Turnover Number [1/s]

Disease

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Disease on EC 3.3.2.1 - isochorismatase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Breast Neoplasms

Knockdown of ISOC1 suppresses cell proliferation in pancreatic cancer in vitro.

30944620

Gastrointestinal Neoplasms

Isochorismatase domain-containing protein 1 (ISOC1) participates in DNA damage repair and inflammation-related pathways to promote lung cancer development.

33889521

Infections

Critical role of bacterial isochorismatase in the autophagic process induced by Acinetobacter baumannii in mammalian cells.

27432399

Iron Deficiencies

Bacterial production of transdihydroxycyclohexadiene carboxylates by metabolic pathway engineering.

8936326

Lung Neoplasms

Isochorismatase domain-containing protein 1 (ISOC1) participates in DNA damage repair and inflammation-related pathways to promote lung cancer development.

33889521

Neoplasms

Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a.

17658461

Stomach Neoplasms

ISOC1 promotes the proliferation of gastric cancer cells by positively regulating CDK19.

33275227

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