3.3.2.1: isochorismatase

This is an abbreviated version!
For detailed information about isochorismatase, go to the full flat file.

Reaction

Synonyms

2,3 dihydro-2,3 dihydroxybenzoate synthase, 2,3-dihydro-2,3-dihydroxybenzoate synthase, 2,3-dihydroxy-2,3-dihydrobenzoate synthase, 2,3-dihydroxy-2,3-dihydrobenzoic synthase, AngB, AngB-ISC, EntB, IHL, IPL, ISC, ISOC2, isochorismatase, isochorismatase domain containing 2, isochorismatase hydrolase, isochorismate lyase, Mhpg, PchB, SOI1, VabB, VabB-ISC

ECTree

     3 Hydrolases

         3.3 Acting on ether bonds

             3.3.2 Ether hydrolases

                3.3.2.1 isochorismatase

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Results	in table
4481	AA Sequence
1	Application
1	CAS Registry Number
9	Cloned(Commentary)
7	Crystallization (Commentary)
19	Disease/ Diagnostics
8	General Information
2	IC50 Value
6	Inhibitors
2	Ki Value [mM]
9	KM Value [mM]
2	Localization
11	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
25	Organism
5	Pathway
8	PDB ID
2	pH Optimum
1	pH Stability
28	Protein Variants
5	Purification (Commentary)
5	Reaction
3	Reaction Type
22	Reference
6	Source Tissue
1	Storage Stability
23	Substrates and Products (Substrate)
15	Subunits
51	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
12	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.3.2.1 - isochorismatase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(+/-)-3-[(1-carboxyethenyl)oxy]-2-hydroxy-6-cyclohexene-1-carboxylic acid + H2O

3,4-dihydroxy-cyclohex-1-enecarboxylic acid + pyruvate

Escherichia coli

-

-

326413

-

326413

?

(+/-)-3-[(1-carboxyethenyl)oxy]-cyclohepta-1,6-diene-1-carboxylate + H2O

(S)-3-hydroxy-cyclohepta-1,6-dienecarboxylic acid + pyruvate

Escherichia coli

-

i.e. (S)-3-(1-carboxyvinyloxy)-cyclohepta-1,6-dienecarboxylic acid

326413

-

326413

?

(+/-)-3-[(carboxyethenyl)oxy]-1-cyclohexene-1-carboxylic acid + H2O

(S)-3-hydroxycyclohex-1-enecarboxylic acid + pyruvate

Escherichia coli

-

-

326413

-

326413

?

(+/-)-cis-3-[(carboxyethenyl)oxy]-4-cyclohexene-1-carboxylic acid + H2O

(R)-5-hydroxycyclohex-3-enecarboxylic acid + pyruvate

Escherichia coli

-

-

326413

-

326413

?

Chorismate

Prephenate

Pseudomonas aeruginosa

-

promiscuous reaction

669382

-

-

?

chorismate + H2O

3,4-dihydroxy-cyclohexa-1,5-dienecarboxylic acid + pyruvate

Escherichia coli

-

slow hydrolysis

326413

-

326413

?

isochorismate + H2O

(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

7 entries

isochorismate + H2O

2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

10 entries

isochorismate + H2O

(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Escherichia coli

-

-

724541

-

-

?

isochorismate + H2O

(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Oleispira Antarctica

L7MTK1

-

732399

-

-

?

isochorismate + H2O

(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Vibrio anguillarum

Q5DK16, Q6W4P9

-

752664

-

-

?

isochorismate + H2O

(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Vibrio anguillarum 775

Q5DK16, Q6W4P9

-

752664

-

-

?

isochorismate + H2O

(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Vibrio anguillarum ATCC 68554

Q5DK16, Q6W4P9

-

752664

-

-

?

isochorismate + H2O

(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Vibrio cholerae

P0C6D3

-

731045

-

-

?

isochorismate + H2O

(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Vibrio cholerae N16961

P0C6D3

-

731045

-

-

?

isochorismate + H2O

2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Escherichia coli

-

-

326413

-

326413

?

isochorismate + H2O

2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Escherichia coli

-

biosynthesis of enterobactin

326413

-

326413

?

isochorismate + H2O

2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Homo sapiens

-

-

683122

-

-

?

isochorismate + H2O

2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Klebsiella aerogenes

-

-

326412

-

326412

?

isochorismate + H2O

2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Klebsiella pneumoniae

-

-

326416

-

326416

?

isochorismate + H2O

2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Mus musculus

-

-

683122

-

-

?

isochorismate + H2O

2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Pseudomonas aeruginosa

-

main reaction

669382

-

-

?

isochorismate + H2O

2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Verticillium dahliae

-

-

702756

-

-

?

isochorismate + H2O

2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Verticillium dahliae

-

isochorismatase converts isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate and inhibits salicylic acid formation

702756

-

-

?

isochorismate + H2O

2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Vibrio anguillarum

-

-

669078

-

-

?