3.2.1.53: beta-N-acetylgalactosaminidase

This is an abbreviated version!
For detailed information about beta-N-acetylgalactosaminidase, go to the full flat file.

Reaction

Synonyms

Bacillus beta-GlcNAcase, beta-acetylgalactosaminidase, beta-D-N-acetylgalactosaminidase, beta-N-acetylgalactosaminidase, N-acetyl-beta-D-galactosaminidase, N-acetyl-beta-galactosaminidase, N-acetylgalactosaminidase, NgaP

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.53 beta-N-acetylgalactosaminidase

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Results	in table
2	Activating Compound
1	AA Sequence
1	Application
1	CAS Registry Number
1	Cloned(Commentary)
53	Disease/ Diagnostics
2	General Stability
8	IC50 Value
26	Inhibitors
4	kcat/KM [mM/s]
2	Ki Value [mM]
7	KM Value [mM]
3	Localization
1	Metals/Ions
5	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
10	Organism
4	pH Optimum
2	pH Range
4	Protein Variants
3	Purification (Commentary)
2	Reaction
1	Reaction Type
10	Reference
12	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
24	Substrates and Products (Substrate)
1	Subunits
12	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.2.1.53 - beta-N-acetylgalactosaminidase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

AgNO3

Bos taurus

-

-

136607

Cu2+

2 entries

Fe2+

Bacillus sp. (in: Bacteria)

-

enzyme activity completely inhibited in the presence of 10 mM FeSO4

136608

Hg2+

Paenibacillus sp.

E9RH20

5 mM, strong inhibition

715593

mannose

Phlebotomus papatasi

-

inhibition of beta-N-acetylgalactosaminidase but activation of alpha-N-acetylgalactosaminidase, three concentrations of 10, 50, and 100 mM tested

679943

methyl 2,5-dideoxy-2,5-imino-D-allonamide

2 entries

methyl 2,5-dideoxy-2,5-imino-D-mannonamide

2 entries

methyl 2,5-dideoxy-2,5-imino-D-talonamide

2 entries

methyl 2,5-dideoxy-2,5-imino-L-gulonamide

2 entries

N-acetylgalactosamine

4 entries

N-acetylgalactosaminide thiazoline

Paenibacillus sp.

E9RH20

competitive

715593

N-acetylglucosamine

2 entries

N-acetylglucosaminide thiazoline

Paenibacillus sp.

E9RH20

-

715593

Ni2+

Paenibacillus sp.

E9RH20

5 mM, strong inhibition

715593

p-hydroxymercuribenzoate

Bos taurus

-

-

136607

Urea

Bacillus sp. (in: Bacteria)

-

relative activity in presence of 2 M 32%

136608

Zn2+

Bacillus sp. (in: Bacteria)

-

enzyme activity completely inhibited in the presence of 10 mM ZnSO4

136608

Cu2+

Bacillus sp. (in: Bacteria)

-

enzyme activity completely inhibited in the presence of 10 mM CuSO4

136608

Cu2+

Paenibacillus sp.

E9RH20

5 mM, strong inhibition

715593

methyl 2,5-dideoxy-2,5-imino-D-allonamide

Aspergillus oryzae

-

-

732374

methyl 2,5-dideoxy-2,5-imino-D-allonamide

Homo sapiens

-

-

732374

methyl 2,5-dideoxy-2,5-imino-D-mannonamide

Aspergillus oryzae

-

-

732374

methyl 2,5-dideoxy-2,5-imino-D-mannonamide

Homo sapiens

-

-

732374

methyl 2,5-dideoxy-2,5-imino-D-talonamide

Aspergillus oryzae

-

-

732374

methyl 2,5-dideoxy-2,5-imino-D-talonamide

Homo sapiens

-

-

732374

methyl 2,5-dideoxy-2,5-imino-L-gulonamide

Aspergillus oryzae

-

-

732374

methyl 2,5-dideoxy-2,5-imino-L-gulonamide

Homo sapiens

-

-

732374

N-acetylgalactosamine

Bacillus sp. (in: Bacteria)

-

relative activity in presence of 10 mM 50%, in presence of 50 mM 12%

136608

N-acetylgalactosamine

Bos taurus

-

competitive inhibition

136607

N-acetylgalactosamine

Phlebotomus papatasi

-

dose dependent inhibition, at lower levels than inhibition by N-acetylglucosamine, three concentrations of 10, 50, and 100 mM tested

679943

N-acetylgalactosamine

Rattus norvegicus

-

-

136606

N-acetylglucosamine

Bos taurus

-

no inhibition at N-acetylglucosamine concentration of 40 mM

136607

N-acetylglucosamine

Phlebotomus papatasi

-

constant inhibition, three concentrations of 10, 50, and 100 mM tested

679943