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3.2.1.53: beta-N-acetylgalactosaminidase

This is an abbreviated version!
For detailed information about beta-N-acetylgalactosaminidase, go to the full flat file.

Word Map on EC 3.2.1.53

Reaction

(GalNAcbeta(1-4))n
+
H2O
=
(GalNAcbeta(1-4))n-1
 +
2-(acetylamino)-2-deoxy-beta-D-galactopyranose

Synonyms

Bacillus beta-GlcNAcase, beta-acetylgalactosaminidase, beta-D-N-acetylgalactosaminidase, beta-N-acetylgalactosaminidase, N-acetyl-beta-D-galactosaminidase, N-acetyl-beta-galactosaminidase, N-acetylgalactosaminidase, NgaP

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.53 beta-N-acetylgalactosaminidase

Substrates Products

Substrates Products on EC 3.2.1.53 - beta-N-acetylgalactosaminidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-methylumbelliferyl beta-N-acetylgalactosaminide + H2O
4-methylumbelliferone + N-acetyl-beta-D-galactosamine
show the reaction diagram
-
-
-
-
?
4-methylumbelliferyl-beta-D-N-acetylgalactosaminide + H2O
4-methylumbelliferone + N-acetyl-beta-D-galactosamine
show the reaction diagram
4-nitrophenyl beta-acetylgalactosaminide + H2O
4-nitrophenol + beta-acetylgalactosamine
show the reaction diagram
4-nitrophenyl beta-N-acetylglucosaminide + H2O
beta-N-acetylglucosamine + 4-nitrophenol
show the reaction diagram
1-3% of the activity with 4-nitrophenyl beta-N-acetylgalactosaminide
-
-
?
4-nitrophenyl N-acetyl-beta-D-galactosaminopyranoside + H2O
N-acetyl-D-galactosamine + 4-nitrophenol
show the reaction diagram
-
-
-
?
4-nitrophenyl-N-acetyl-beta-D-galactosaminide + H2O
4-nitrophenol + N-acetyl-beta-D-glucosamine
show the reaction diagram
-
activity measured in whole fly homogenates, substrate concentration of 6 mM in citrate buffer, flies of arid regions tend to produce more beta-N-acetylgalactosaminidase than those originating in sugar-rich environments
-
-
?
beta-N-acetylgalactosaminylated oligosaccharides + H2O
?
show the reaction diagram
beta-phenyl-N-acetylgalactosamines + H2O
?
show the reaction diagram
-
substrate specificity 85%
-
-
?
GalNAc-beta-1,3-Gal-alpha-1,4-Gal-beta-1,4-Glc-beta-1,1-Cer + H2O
GalNAc + Gal-alpha-1,4-Gal-beta-1,4-Glc-beta-1,1-Cer
show the reaction diagram
i.e. globotetraosylceramide, 39% of the activity with GalNAc-1,4-Gal-1,4-Glc-1,1-Cer
-
-
?
GalNAc-beta-1,4-Gal-beta-1,4-Glc-beta-1,1-Cer
GalNAc + Gal-beta-1,4-Glc-beta-1,1-Cer
show the reaction diagram
i.e. asialo-GM2
-
-
?
N-acetyl-beta-D-galactosaminides + H2O
?
show the reaction diagram
N-acetyl-beta-D-galactosaminides + H2O
N-acetyl-D-galactosamine + an alcohol
show the reaction diagram
p-nitrophenyl beta-N-acetylgalactosaminide + H2O
?
show the reaction diagram
additional information
?
-
enzyme cleaves the nonreducing terminal beta-GalNAc residues of gangliotriaosylceramide and globotetraosylceramide. Enzyme prefers the GalNAc-1,4-linkage over the GalNAc-1,3-linkage
-
-
?