3.2.1.102: blood-group-substance endo-1,4-beta-galactosidase

This is an abbreviated version, for detailed information about blood-group-substance endo-1,4-beta-galactosidase, go to the full flat file.

Reaction

Endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances =

Synonyms

ABase, blood group A- and B-cleaving endo-beta-galactosidase, blood group A/B antigen-specific endo-beta-galactosidase, blood group antigen-cleaving endo-beta-galactosidase, blood group glycotope-cleaving endo-beta-galactosidase, E-ABase, EABase, endo-beta-galactosidase, endo-beta-galactosidase C, endo-beta-galactosidase DII, EndoGalC, galactosidase, endo-beta-, GH98CBM51, inverting endo-beta-galactosidase, More, Sp3GH98, Sp4GH98

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.102 blood-group-substance endo-1,4-beta-galactosidase

Engineering

Engineering on EC 3.2.1.102 - blood-group-substance endo-1,4-beta-galactosidase

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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D429A
-
the mutants shows reduced activity compared to the wild type enzyme
D453A
-
the mutation results in complete loss of activity
E354A
-
the activity of the E354A mutant with nonactivated natural substrates is 1100fold lower than that of the wild type enzyme, while its activity is only 10fold lower when assayed with 2,4-dinitrophenyl-beta-A-trisaccharide
E467A
-
the mutants shows slightly reduced activity compared to the wild type enzyme
E506A
-
the mutation results in complete loss of activity
additional information