Application | Comment | Organism |
---|---|---|
medicine | the absence of the alphaGal epitope or the exposed N-acetylglucosamine terminal in transgenic mice expressing the enzyme can play a critical role in the proliferation of basal keratinocytes and differentiation of them into the spinous cells | Clostridium perfringens |
Cloned (Comment) | Organism |
---|---|
expression in Mus musculus | Clostridium perfringens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mice expressing the enzyme systemically have rough and flaky skin which becomes detectable around 5 days after birth and becomes obscure by 2 weeks after birth. In transgenic mice, proliferating keratinocytes increase approximately 3fold in epidermis compared to wild-type. In transgenic epidermis, the expression domain of cytokeratin 14 increases from 1-2 layers to 4-5 layers and co-expresses with cytokeratin 6 and 10 in the upper layers. Transgenic mice also show delayed development of the barrier function around 8 days postnatal, and acquire the function by 12 days postnatal | Clostridium perfringens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium perfringens | - |
expression in Mus musculus | - |
Source Tissue | Comment | Organism | Textmining |
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