3.1.6.4: N-acetylgalactosamine-6-sulfatase

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For detailed information about N-acetylgalactosamine-6-sulfatase, go to the full flat file.

Reaction

Synonyms

6-sulfatase, acetylgalactosamine 6-sulfatase, AtsA2, chondroitin sulfatase, chondroitinase, chondroitinsulfatase, galactose-6-sulfatase, galactose-6-sulfate sulfatase, GalNAc6S sulfatase, GALNS, N-acetylgalactosamine 6-sulfatase, N-acetylgalactosamine 6-sulphate sulphatase, N-acetylgalactosamine-6-sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, sulfatase, acetylgalactosamine 6-, sulfatase, chondroitin

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.6 Sulfuric-ester hydrolases

                3.1.6.4 N-acetylgalactosamine-6-sulfatase

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Results	in table
6	Activating Compound
802	AA Sequence
12	Application
2	CAS Registry Number
9	Cloned(Commentary)
1	Crystallization (Commentary)
778	Disease/ Diagnostics
1	Expression
7	General Information
2	General Stability
1	IC50 Value
40	Inhibitors
14	KM Value [mM]
5	Localization
23	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
45	Organism
2	Pathway
4	PDB ID
12	pH Optimum
2	pH Range
3	Posttranslational Modification
42	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
43	Reference
38	Source Tissue
7	Specific Activity [micromol/min/mg]
4	Storage Stability
55	Substrates and Products (Substrate)
7	Subunits
31	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]

Crystallization

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Crystallization on EC 3.1.6.4 - N-acetylgalactosamine-6-sulfatase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

modeling of structure and molecular docking against galactose-6-sulfate, N-acetylgalactosamine-6-sulfate, keratan sulfate, chondroitin-6-sulfate, and the artificial substrate 4-methylumbelliferyl-beta-D-galactopyranoside-6-sulfate. Amino acids involved in ligand interaction correlate with those observed in other human sulfatases, and mutations within the active cavity reduce affinity of all evaluated ligands

Homo sapiens

P34059

730366