3.1.6.4: N-acetylgalactosamine-6-sulfatase

This is an abbreviated version!
For detailed information about N-acetylgalactosamine-6-sulfatase, go to the full flat file.

Reaction

Synonyms

6-sulfatase, acetylgalactosamine 6-sulfatase, AtsA2, chondroitin sulfatase, chondroitinase, chondroitinsulfatase, galactose-6-sulfatase, galactose-6-sulfate sulfatase, GalNAc6S sulfatase, GALNS, N-acetylgalactosamine 6-sulfatase, N-acetylgalactosamine 6-sulphate sulphatase, N-acetylgalactosamine-6-sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, sulfatase, acetylgalactosamine 6-, sulfatase, chondroitin

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.6 Sulfuric-ester hydrolases

                3.1.6.4 N-acetylgalactosamine-6-sulfatase

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Results	in table
6	Activating Compound
802	AA Sequence
12	Application
2	CAS Registry Number
9	Cloned(Commentary)
1	Crystallization (Commentary)
778	Disease/ Diagnostics
1	Expression
7	General Information
2	General Stability
1	IC50 Value
40	Inhibitors
14	KM Value [mM]
5	Localization
23	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
45	Organism
2	Pathway
4	PDB ID
12	pH Optimum
2	pH Range
3	Posttranslational Modification
42	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
43	Reference
38	Source Tissue
7	Specific Activity [micromol/min/mg]
4	Storage Stability
55	Substrates and Products (Substrate)
7	Subunits
31	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]

KM Value

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KM Value on EC 3.1.6.4 - N-acetylgalactosamine-6-sulfatase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

4.4

4-Methylumbelliferyl sulfate

Homo sapiens

-

recombinant enzyme

135654

0.008

galactosamine 6-sulfate

Homo sapiens

-

-

135655

0.013

Galactose 6-sulfate

Homo sapiens

-

-

135655

0.03

GalNAc-4-SO4-(GlcUA-GalNAc-4-SO4)2

Rattus norvegicus

-

-

135652

0.049

GalNAc-4-SO4-(GlcUA-GalNAc-4-SO4)3

Rattus norvegicus

-

-

135652

0.064

GalNAc-4-SO4-(GlcUA-GalNAc-4-SO4)4

Rattus norvegicus

-

-

135652

0.027

GalNAc-4-SO4-GlcUA-GalNAc-4-SO4

Rattus norvegicus

-

-

135652

0.12

N-acetylgalactosamine 6-sulfate-beta(1-4)glucuronic acid-beta(1-3)-N-acetylgalactosaminitol 6-sulfate

Homo sapiens

-

-

135647

0.012 - 0.015

O-(beta-D-6-sulfo-2-acetamido-2-deoxygalactosyl)-(1-4)-O-beta-D-glucuronosyl-(1-3)-O-beta-D-6-sulfo-2-acetamido-2-deoxy-galactitol

2 entries

0.05 - 0.096

O-(beta-D-sulfogalactosyl)-(1-4)-1,5-anhydro-D-mannitol 6-sulfate

2 entries

0.0125

oligosaccharide substrate derived from chondroitin 6-sulfate

Homo sapiens

-

-

135656

-

0.05

oligosaccharide substrates derived from keratan sulfate

Homo sapiens

-

-

135656

-

0.012

O-(beta-D-6-sulfo-2-acetamido-2-deoxygalactosyl)-(1-4)-O-beta-D-glucuronosyl-(1-3)-O-beta-D-6-sulfo-2-acetamido-2-deoxy-galactitol

Homo sapiens

-

liver enzyme

135654

0.015

O-(beta-D-6-sulfo-2-acetamido-2-deoxygalactosyl)-(1-4)-O-beta-D-glucuronosyl-(1-3)-O-beta-D-6-sulfo-2-acetamido-2-deoxy-galactitol

Homo sapiens

-

recombinant enzyme

135654

0.05

O-(beta-D-sulfogalactosyl)-(1-4)-1,5-anhydro-D-mannitol 6-sulfate

Homo sapiens

-

liver enzyme

135654

0.096

O-(beta-D-sulfogalactosyl)-(1-4)-1,5-anhydro-D-mannitol 6-sulfate

Homo sapiens

-

recombinant enzyme

135654