3.1.6.4: N-acetylgalactosamine-6-sulfatase

This is an abbreviated version!
For detailed information about N-acetylgalactosamine-6-sulfatase, go to the full flat file.

Reaction

Synonyms

6-sulfatase, acetylgalactosamine 6-sulfatase, AtsA2, chondroitin sulfatase, chondroitinase, chondroitinsulfatase, galactose-6-sulfatase, galactose-6-sulfate sulfatase, GalNAc6S sulfatase, GALNS, N-acetylgalactosamine 6-sulfatase, N-acetylgalactosamine 6-sulphate sulphatase, N-acetylgalactosamine-6-sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, sulfatase, acetylgalactosamine 6-, sulfatase, chondroitin

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.6 Sulfuric-ester hydrolases

                3.1.6.4 N-acetylgalactosamine-6-sulfatase

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Results	in table
6	Activating Compound
802	AA Sequence
12	Application
2	CAS Registry Number
9	Cloned(Commentary)
1	Crystallization (Commentary)
778	Disease/ Diagnostics
1	Expression
7	General Information
2	General Stability
1	IC50 Value
40	Inhibitors
14	KM Value [mM]
5	Localization
23	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
45	Organism
2	Pathway
4	PDB ID
12	pH Optimum
2	pH Range
3	Posttranslational Modification
42	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
43	Reference
38	Source Tissue
7	Specific Activity [micromol/min/mg]
4	Storage Stability
55	Substrates and Products (Substrate)
7	Subunits
31	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]

General Information

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General Information on EC 3.1.6.4 - N-acetylgalactosamine-6-sulfatase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

2 entries

metabolism

Homo sapiens

P34059

modification of expression of the enzyme regulates the content of chondroitin sulfate

680928

physiological function

4 entries

malfunction

Homo sapiens

P34059

mucopolysaccharidosis IVA, MPS IVA, is an autosomal recessive disorder caused by N-acetylgalactosamine-6-sulfate sulfatase deficiency and leading to lysosomal accumulation of the glycosaminoglycans keratan sulfate and chondroitin-6-sulfate

715797

malfunction

Homo sapiens

P34059

deficiencies of N-acetylgalactosamine-6-sulfatase is associated with the mucopolysaccharidoses

680928

physiological function

Rattus norvegicus

P50430

in post-natal ventral rat prostate, a distinct and reciprocal localization of arylsulfatase B and N-acetylgalactosamine-6-sulfatase is seen, with arylsulfatase B predominant in the stroma and N-acetylgalactosamine-6-sulfatase predominant in the epithelium. Estrogen treatment does not inhibit the increase in GALNS activity between days 5 and 30

730284

physiological function

Homo sapiens

P34059

in prostate stem cells, when N-acetylgalactosamine-4-sulfatase ARSB is reduced by silencing or galactosamine-N-acetyl-6-sulfatase GALNS is increased by overexpression, activity of non-receptor tyrosine phosphatase SHP2 declines, attributable to increased binding of SHP2 with C4S. This leads to increases in phospho-ERK1/2, Myc/Max nuclear DNA binding, DNA methyltransferase (DNMT) activity and expression, and methylation of the Dickkopf Wnt signaling pathway inhibitor (DKK)3 promoter and to reduced DKK3 expression. Since DKK3 negatively regulates Wnt/beta-catenin signaling, silencing of ARSB or overexpression of GALNS increases Wnt/beta-catenin signaling

751772

physiological function

Bifidobacterium breve

-

strain is able to grow on N-acetylglucosamine-6-sulfate, while N-acetylglucosamine-3-sulfate, N-acetylgalactosamine-3-sulfate, and N-acetylgalactosamine-6-sulfate do not support appreciable growth. Gene cluster Ats2 is required for N-acetylglucosamine-6-sulfate metabolism

749660

physiological function

Bifidobacterium breve UCC2003

-

strain is able to grow on N-acetylglucosamine-6-sulfate, while N-acetylglucosamine-3-sulfate, N-acetylgalactosamine-3-sulfate, and N-acetylgalactosamine-6-sulfate do not support appreciable growth. Gene cluster Ats2 is required for N-acetylglucosamine-6-sulfate metabolism

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