3.1.21.B1: endonuclease Q

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For detailed information about endonuclease Q, go to the full flat file.

Reaction

endonucleolytic cleavage of the phosphodiester bond 5' from deoxyinosine, forming a 5'-phosphate terminus and a 3'-hydroxyl terminus. DNAs containing deoxyuridine, 7-deaza-2'-deoxyxanthosine or an apurinic/apyrimidinic site are also cleaved =

Synonyms

BpuEndoQ, EndoQ, PF1551, PfuEndoQ, TK0887

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters

                3.1.21.B1 endonuclease Q

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6	General Information
1	Metals/Ions
3	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
13	Organism
4	pH Optimum
1	pH Range
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19	Protein Variants
5	Purification (Commentary)
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11	Reference
21	Substrates and Products (Substrate)
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Metals Ions

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Metals Ions on EC 3.1.21.B1 - endonuclease Q

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METALS and IONS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Zn2+

Pyrococcus furiosus

Q8U0N5

PfuEndoQ recognizes a deaminated base using a highly conserved pocket adjacent to a Zn2+-binding site and hydrolyses a phosphodiester bond using two Zn2+ ions. The PfuEndoQ-DNA complex is stabilized by a Zn-binding domain and a C-terminal helical domain, and the complex may recruit downstream proteins in the DNA repair pathway

751750