3.1.21.B1: endonuclease Q

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For detailed information about endonuclease Q, go to the full flat file.

Reaction

endonucleolytic cleavage of the phosphodiester bond 5' from deoxyinosine, forming a 5'-phosphate terminus and a 3'-hydroxyl terminus. DNAs containing deoxyuridine, 7-deaza-2'-deoxyxanthosine or an apurinic/apyrimidinic site are also cleaved =

Synonyms

BpuEndoQ, EndoQ, PF1551, PfuEndoQ, TK0887

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters

                3.1.21.B1 endonuclease Q

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Results	in table
2	Activating Compound
4	AA Sequence
5	Cloned(Commentary)
1	Crystallization (Commentary)
6	General Information
1	Metals/Ions
3	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
13	Organism
4	pH Optimum
1	pH Range
1	pI Value
19	Protein Variants
5	Purification (Commentary)
1	Reaction
11	Reference
21	Substrates and Products (Substrate)
3	Subunits
15	Synonyms
4	Temperature Optimum [°C]
1	Temperature Range [°C]

Natural Substrates Products

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Natural Substrates Products on EC 3.1.21.B1 - endonuclease Q

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

deoxyinosine-containing deoxyoligonucleotide + H2O

?

Pyrococcus furiosus

Q8U0N5

the enzyme is involved in damaged DNA repair

731387

-

-

?

deoxyinosine-containing DNA + H2O

?

2 entries

DNA + H2O

?

Bacillus pumilus

A0A3G1H3K8

the enzyme recognizes uracil, xanthine, and the AP site in DNA, and is probably involved in a specific repair process for damaged bases

750101

-

-

?

deoxyinosine-containing DNA + H2O

?

Pyrococcus furiosus

Q8U0N5

the enzyme cleaves the phosphodiester bond 5' from deoxyinosine. The enzyme is an endonuclease that functions in a repair process for damaged bases in archaeal cells

730525

-

-

?

deoxyinosine-containing DNA + H2O

?

Thermococcus kodakarensis

Q5JI33

the enzyme cleaves the phosphodiester bond 5' from deoxyinosine. The enzyme is an endonuclease that functions in a repair process for damaged bases in archaeal cells

730525

-

-

?