3.1.21.B1: endonuclease Q

This is an abbreviated version!
For detailed information about endonuclease Q, go to the full flat file.

Word Map on EC 3.1.21.B1

3.1.21.B1

deaminate

archaea

furiosus

pyrococcus

uracil

hypoxanthine

phosphodiester

strand

hyperthermophilic

cytosine

endov

deoxyinosine

thermococcales

xanthine

glycosylase

thrive

nick

euryarchaeon

abasic

lesion-specific

Reaction

endonucleolytic cleavage of the phosphodiester bond 5' from deoxyinosine, forming a 5'-phosphate terminus and a 3'-hydroxyl terminus. DNAs containing deoxyuridine, 7-deaza-2'-deoxyxanthosine or an apurinic/apyrimidinic site are also cleaved =

Synonyms

BpuEndoQ, EndoQ, PF1551, PfuEndoQ, TK0887

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters

3.1.21.B1 endonuclease Q

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Results	in table
2	Activating Compound
4	AA Sequence
5	Cloned(Commentary)
1	Crystallization (Commentary)
6	General Information
1	Metals/Ions
3	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
13	Organism
4	pH Optimum
1	pH Range
1	pI Value
19	Protein Variants
5	Purification (Commentary)
1	Reaction
11	Reference
21	Substrates and Products (Substrate)
3	Subunits
15	Synonyms
4	Temperature Optimum [°C]
1	Temperature Range [°C]

Reference

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Reference on EC 3.1.21.B1 - endonuclease Q

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730525

Shiraishi, M.; Ishino, S.; Yamagami, T.; Egashira, Y.; Kiyonari, S.; Ishino, Y.

A novel endonuclease that may be responsible for damaged DNA base repair in Pyrococcus furiosus

Nucleic Acids Res.

2853-2863

2015

Thermococcus kodakarensis (Q5JI33), Thermococcus kodakarensis, Pyrococcus furiosus (Q8U0N5), Pyrococcus furiosus

25694513

731387

Ishino, S.; Makita, N.; Shiraishi, M.; Yamagami, T.; Ishino, Y.

EndoQ and EndoV work individually for damaged DNA base repair in Pyrococcus furiosus

Biochimie

118

264-269

2015

Pyrococcus furiosus (Q8U0N5), Pyrococcus furiosus

26116888

750101

Shiraishi, M.; Ishino, S.; Cann, I.; Ishino, Y.

A functional endonuclease Q exists in the bacterial domain identification and characterization of endonuclease Q from Bacillus pumilus

Biosci. Biotechnol. Biochem.

931-937

2017

Bacillus pumilus (A0A3G1H3K8), Bacillus pumilus

28095753

751750

Miyazono, K.I.; Ishino, S.; Makita, N.; Ito, T.; Ishino, Y.; Tanokura, M.

Crystal structure of the novel lesion-specific endonuclease PfuEndoQ from Pyrococcus furiosus

Nucleic Acids Res.

4807-4818

2018

Pyrococcus furiosus (Q8U0N5), Pyrococcus furiosus, Pyrococcus furiosus ATCC 43587 (Q8U0N5)

29660024

752193

Shiraishi, M.; Ishino, S.; Yoshida, K.; Yamagami, T.; Cann, I.; Ishino, Y.

PCNA is involved in the EndoQ-mediated DNA repair process in Thermococcales

Sci. Rep.

25532

2016

Thermococcus kodakarensis (Q5JI33), Pyrococcus furiosus (Q8U0N5), Pyrococcus furiosus, Pyrococcus furiosus ATCC 43587 (Q8U0N5)

27150116

752239

Shiraishi, M.; Ishino, S.; Heffernan, M.; Cann, I.; Ishino, Y.

The mesophilic archaeon Methanosarcina acetivorans counteracts uracil in DNA with multiple enzymes EndoQ, ExoIII, and UDG

Sci. Rep.

15791

2018

Methanosarcina acetivorans (Q8TT02), Methanosarcina acetivorans, Methanosarcina acetivorans ATCC 35395 (Q8TT02)

30361558