3.1.11.6: exodeoxyribonuclease VII

This is an abbreviated version!
For detailed information about exodeoxyribonuclease VII, go to the full flat file.

Word Map on EC 3.1.11.6

3.1.11.6

single-stranded

nucleases

reca

sbccd

methyl-directed

analysis

recbcd

Reaction

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates =

Synonyms

E. coli exonuclease VII, endodeoxyribonuclease VII, Escherichia coli exonuclease VII, exonuclease VII, ExoVII, nuclease, exodeoxyribo-, VII, RecBCD, XseA, XseB

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.11 Exodeoxyribonucleases producing 5′-phosphomonoesters

3.1.11.6 exodeoxyribonuclease VII

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Results	in table
6	Activating Compound
66501	AA Sequence
11	Application
1	CAS Registry Number
5	Cloned(Commentary)
1	Crystallization (Commentary)
11	General Information
1	General Stability
7	Inhibitors
2	Localization
4	Metals/Ions
6	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
76	Organism
6	PDB ID
2	pH Optimum
2	pH Stability
26	Protein Variants
5	Purification (Commentary)
1	Reaction
1	Reaction Type
36	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
66	Substrates and Products (Substrate)
6	Subunits
30	Synonyms
2	Temperature Optimum [°C]
4	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 3.1.11.6 - exodeoxyribonuclease VII

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EDTA

3 entries

N-ethylmaleimide

Escherichia coli

47% inhibition in absence of mercaptoethanol

134037

phosphate

Thermotoga maritima

inhibits nuclease activity at 80°C; strongly inhibits, almost complete inhibition by 50 mM

700496

sulfate

Thermotoga maritima

strongly inhibits, almost complete inhibition by 50 mM

700496

additional information

Thermotoga maritima

is not active in standard Escherichia coli ExoVII buffer. Acetate has no effect

700496