3.1.11.6: exodeoxyribonuclease VII
This is an abbreviated version!
For detailed information about exodeoxyribonuclease VII, go to the full flat file.
Word Map on EC 3.1.11.6
Reaction
Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates =
Synonyms
E. coli exonuclease VII, endodeoxyribonuclease VII, Escherichia coli exonuclease VII, exonuclease VII, ExoVII, nuclease, exodeoxyribo-, VII, RecBCD, XseA, XseB
ECTree
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Substrates Products on EC 3.1.11.6 - exodeoxyribonuclease VII
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
polydeoxyribonucleotides + H2O
hydrolyzed single-stranded DNA
-
-
-
?
duplex DNA containing single-stranded termini + H2O
hydrolyzed single-stranded DNA
-
-
-
?
duplex DNA containing single-stranded termini + H2O
hydrolyzed single-stranded DNA
-
-
-
?
single-stranded DNA + H2O
?
-
ExoVII activity is highly processive. It binds ssDNA ends and cleaves its substrate endonucleolytically, releasing oligonucleotide products of various sizes
-
-
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
-
-
-
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
-
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
-
oligonucleotides
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
-
oligonucleotides
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
-
oligonucleotides
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
-
oligonucleotides
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
no activity on circular DNA
exclusively oligonucleotides
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
no activity on circular DNA
exclusively oligonucleotides, no mononucleotide production observed
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
no endonuclease activity
limit products: oligonucleotides: dimers to dodecamers
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
no activity homopolymers
limit products: oligonucleotides: dimers to dodecamers
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
processive degradation
-
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
processive degradation
limit products: oligonucleotides: dimers to dodecamers
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
processive degradation
exclusively oligonucleotides
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
processive degradation
exclusively oligonucleotides, no mononucleotide production observed
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
no activity on DNA-RNA hybrid molecules
exclusively oligonucleotides
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
no activity on DNA-RNA hybrid molecules
exclusively oligonucleotides, no mononucleotide production observed
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
single stranded DNA of at least 10-20 nucleotides are required for maximal activity
exclusively oligonucleotides, no mononucleotide production observed
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
heat-denatured DNA
exclusively oligonucleotides
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
no activity on RNA
exclusively oligonucleotides
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
no activity on RNA
exclusively oligonucleotides, no mononucleotide production observed
?
single-stranded DNA + H2O
hydrolyzed single-stranded DNA
-
-
-
?
thymine dimers + H2O
hydrolyzed single-stranded DNA
-
possible role in methyl-directed mismatch repair system
-
?
thymine dimers + H2O
hydrolyzed single-stranded DNA
possible role in methyl-directed mismatch repair system
-
?
thymine dimers + H2O
hydrolyzed single-stranded DNA
-
possible role in repair of ultraviolet damage
-
?
thymine dimers + H2O
hydrolyzed single-stranded DNA
-
possible role in repair of ultraviolet damage
-
?
thymine dimers + H2O
hydrolyzed single-stranded DNA
-
possible role in repair of ultraviolet damage
-
?
thymine dimers + H2O
hydrolyzed single-stranded DNA
-
possible role in repair of ultraviolet damage
-
?
thymine dimers + H2O
hydrolyzed single-stranded DNA
-
possible role in repair of ultraviolet damage
-
?
thymine dimers + H2O
hydrolyzed single-stranded DNA
-
possible role in repair of ultraviolet damage
-
?
additional information
?
-
-
involved in methyl-directed mismatch repair
-
-
?
additional information
?
-
-
RecBCD subunit RecD is required for initiation of homologous recombination in Escherichia coli and essential for phage lambda recombination, in contrast to exonuclease RecJ, overview
-
-
?
additional information
?
-
-
exonuclease VII can digest ssDNA from 3' ends
-
-
?
additional information
?
-
exonuclease VII cleaves msDNA, e.g. Ec78 and Ec83
-
-
?
additional information
?
-
-
exonuclease VII cleaves msDNA, e.g. Ec78 and Ec83
-
-
?
additional information
?
-
-
mutants lacking ExoVII are viable during all phases of the bacterial life cycle, but cannot compete with wild-type cells during long-term stationary phase incubation. Mutants lacking ExoVII are defective in DNA catabolism
-
-
?
additional information
?
-
-
mutants lacking ExoVII are viable during all phases of the bacterial life cycle, but cannot compete with wild-type cells during long-term stationary phase incubation. Mutants lacking ExoVII are defective in DNA catabolism
-
-
?
additional information
?
-
-
exonuclease VII can digest ssDNA from 3' ends
-
-
?
additional information
?
-
-
ExoVII is refractory to mutation, inactivation appears to be lethal. ExoVII appears to be essential for growth of Haemophilus influenzae, possibly, given its ability to process DNA flaps, indicating a requirement for the activities of this protein in replicative DNA synthesis
-
-
?
additional information
?
-
-
ExoVII is refractory to mutation, inactivation appears to be lethal. ExoVII appears to be essential for growth of Haemophilus influenzae, possibly, given its ability to process DNA flaps, indicating a requirement for the activities of this protein in replicative DNA synthesis
-
-
?
additional information
?
-
-
active site motif with two conserved aspartate residues in the large (XseA/TM1768) subunit. Residues Asp235 and Asp240 are essential for the nuclease activity
-
-
?
additional information
?
-
-
no significant activity on dsDNA. Active site motif with two conserved aspartate residues in the large (XseA/TM1768) subunit. Residues Asp235 and Asp240 are essential for the nuclease activity
-
-
?
