2.3.2.31: RBR-type E3 ubiquitin transferase

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For detailed information about RBR-type E3 ubiquitin transferase, go to the full flat file.

Word Map on EC 2.3.2.31

2.3.2.31

mitophagy

pink1

sequestosome

optineurin

tomm20

lubac

mitofusin

pten-induced

hhari

ariadne

ring-between-ring

sharpin

cullin-ring

fundc1

3-chlorophenylhydrazone

ring-in-between-ring

mitophagosome

ubch7

bcl2l13

ub-conjugating

analysis

medicine

Reaction

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine

[E2 ubiquitin-conjugating enzyme]-L-cysteine

[acceptor protein]-N6-ubiquitinyl-L-lysine

Synonyms

ARIH1, ARIH2, HHARI, HOIP, Parkin, parkin RBR E3 ubiquitin ligase, PRKN, RBR E3, RBR-type E3, RBR-type E3 ligase, RBX1, RFA1, RFA4, RING Finger ABA-Related, RNF144, RNF144A, RNF144AA, RNF144AB, RNF144B, RNF19A, RNF19B, RNF217, RNF31, Triad1

ECTree

2 Transferases

2.3 Acyltransferases

2.3.2 Aminoacyltransferases

2.3.2.31 RBR-type E3 ubiquitin transferase

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Results	in table
1	Activating Compound
19552	AA Sequence
6	Application
7	Cloned(Commentary)
5	Crystallization (Commentary)
297	Disease/ Diagnostics
1	Expression
12	General Information
3	Inhibitors
3	Localization
12	Natural Substrates/ Products (Substrates)
22	Organism
33	PDB ID
1	Posttranslational Modification
23	Protein Variants
1	Purification (Commentary)
3	Reaction
21	Reference
5	Source Tissue
20	Substrates and Products (Substrate)
1	Subunits
31	Synonyms
1	Systematic Name

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Systematic Name on EC 2.3.2.31 - RBR-type E3 ubiquitin transferase

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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming; RBR-type)

RBR-type E3 ubiquitin transferases have two RING fingers separated by an internal motif (IBR, for In Between RING). The enzyme interacts with the CRL (Cullin-RING ubiquitin Ligase) complexes formed by certain RING-type E3 ubiquitin transferase (see EC 2.3.2.27), which include a neddylated cullin scaffold protein and a substrate recognition module. The RING1 domain binds an EC 2.3.2.23, E2 ubiquitin-conjugating enzyme, and transfers the ubiquitin that is bound to it to an internal cysteine residue in the RING2 domain, followed by the transfer of the ubiquitin from RING2 to the substrate [4]. Once the substrate has been ubiquitylated by the RBR-type ligase, it can be ubiqutylated further using ubiquitin carried directly on E2 enzymes, in a reaction catalysed by EC 2.3.2.27. Activity of the RBR-type enzyme is dependent on neddylation of the cullin protein in the CRL complex [2,4]. cf. EC 2.3.2.26, HECT-type E3 ubiquitin transferase, EC 2.3.2.27, RING-type E3 ubiquitin transferase, and EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase.