2.3.2.31: RBR-type E3 ubiquitin transferase
This is an abbreviated version!
For detailed information about RBR-type E3 ubiquitin transferase, go to the full flat file.
Reaction
Synonyms
ARIH1, ARIH2, HHARI, HOIP, Parkin, parkin RBR E3 ubiquitin ligase, PRKN, RBR E3, RBR-type E3, RBR-type E3 ligase, RBX1, RFA1, RFA4, RING Finger ABA-Related, RNF144, RNF144A, RNF144AA, RNF144AB, RNF144B, RNF19A, RNF19B, RNF217, RNF31, Triad1
ECTree
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Localization
Localization on EC 2.3.2.31 - RBR-type E3 ubiquitin transferase
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mitophagy is regulated by a positive ubiquitylation feedback loop in which the PINK1 kinase phosphorylates both ubiquitin and the E3 ubiquitin ligase parkin. This event recruits parkin to the mitochondria
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isoforms RFA1 and RFA4. RFA4 shows specific nuclear localization and promotes nuclear degradation of abscisic acid receptors