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BRENDA support

2.3.2.31: RBR-type E3 ubiquitin transferase

This is an abbreviated version!
For detailed information about RBR-type E3 ubiquitin transferase, go to the full flat file.

Word Map on EC 2.3.2.31

Reaction

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine
+
[acceptor protein]-L-lysine
=
[E2 ubiquitin-conjugating enzyme]-L-cysteine
+
[acceptor protein]-N6-ubiquitinyl-L-lysine

Synonyms

ARIH1, ARIH2, HHARI, HOIP, Parkin, parkin RBR E3 ubiquitin ligase, PRKN, RBR E3, RBR-type E3, RBR-type E3 ligase, RBX1, RFA1, RFA4, RING Finger ABA-Related, RNF144, RNF144A, RNF144AA, RNF144AB, RNF144B, RNF19A, RNF19B, RNF217, RNF31, Triad1

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.31 RBR-type E3 ubiquitin transferase

Source Tissue

Source Tissue on EC 2.3.2.31 - RBR-type E3 ubiquitin transferase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
endogenous Parkin is activated in neuronal cell lines in response to mitochondrial depolarization
Manually annotated by BRENDA team
additional information
-
genes of isoforms RNF19A, RNF19B, RNF144AA, RNF144AB, RNF144B and RNF217 are constitutively expressed in all tissues examined. All proteins contain a RING, in between-ring and transmembrane domain
Manually annotated by BRENDA team