2.3.2.31: RBR-type E3 ubiquitin transferase

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For detailed information about RBR-type E3 ubiquitin transferase, go to the full flat file.

Word Map on EC 2.3.2.31

2.3.2.31

mitophagy

pink1

sequestosome

optineurin

tomm20

lubac

mitofusin

pten-induced

hhari

ariadne

ring-between-ring

sharpin

cullin-ring

fundc1

3-chlorophenylhydrazone

ring-in-between-ring

mitophagosome

ubch7

bcl2l13

ub-conjugating

analysis

medicine

Reaction

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine

[E2 ubiquitin-conjugating enzyme]-L-cysteine

[acceptor protein]-N6-ubiquitinyl-L-lysine

Synonyms

ARIH1, ARIH2, HHARI, HOIP, Parkin, parkin RBR E3 ubiquitin ligase, PRKN, RBR E3, RBR-type E3, RBR-type E3 ligase, RBX1, RFA1, RFA4, RING Finger ABA-Related, RNF144, RNF144A, RNF144AA, RNF144AB, RNF144B, RNF19A, RNF19B, RNF217, RNF31, Triad1

ECTree

2 Transferases

2.3 Acyltransferases

2.3.2 Aminoacyltransferases

2.3.2.31 RBR-type E3 ubiquitin transferase

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Results	in table
1	Activating Compound
19552	AA Sequence
6	Application
7	Cloned(Commentary)
5	Crystallization (Commentary)
297	Disease/ Diagnostics
1	Expression
12	General Information
3	Inhibitors
3	Localization
12	Natural Substrates/ Products (Substrates)
22	Organism
33	PDB ID
1	Posttranslational Modification
23	Protein Variants
1	Purification (Commentary)
3	Reaction
21	Reference
5	Source Tissue
20	Substrates and Products (Substrate)
1	Subunits
31	Synonyms
1	Systematic Name

Inhibitors

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Inhibitors on EC 2.3.2.31 - RBR-type E3 ubiquitin transferase

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methyl (2E)-4-[(2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonyl)amino]but-2-enoate

Homo sapiens

Q96EP0

labels RNF31 with proteome-wide selectivity and effectively inhibits linear polyubiquitin chain formation in vitro and in cells

757071

methyl (2E)-4-[(2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carbonyl)amino]but-2-enoate

Homo sapiens

Q96EP0

compound labels RNF31 RBR at the active site cysteine residue C885 in a time- and concentration-dependent manner. It effectively penetrates mammalian cells to inhibit RNF31 and NF-kappaB activation

757071

additional information

Homo sapiens

Q96EP0

single-domain antibodies can modulate the activity of the E3 ligase HOIP and facilitate crystallization of its catalytic RBR domain. Single domain antibodies may inhibit most, if not all, ubiquitin linear chain formation with both E2 enzymes UbcH5C and UbcH7 equally, one group of antibodies has a small effect on the observed activity with UbcH5C, but drastically slows down linear chain formation with UbcH7

756380