2.3.1.54: formate C-acetyltransferase
This is an abbreviated version!
For detailed information about formate C-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.54
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2.3.1.54
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glycyl
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anaerobiosis
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phosphotransacetylase
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chemostats
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homolactic
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glucose-limited
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microaerobic
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pyruvate:ferredoxin
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mixed-acid
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acetoin
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flavodoxins
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activase
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5\'-deoxyadenosyl
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dual-phase
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hypophosphite
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knappe
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benzylsuccinate
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embden-meyerhof-parnas
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biotechnology
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nutrition
- 2.3.1.54
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glycyl
- anaerobiosis
- phosphotransacetylase
-
chemostats
-
homolactic
-
glucose-limited
-
microaerobic
-
pyruvate:ferredoxin
-
mixed-acid
- acetoin
- flavodoxins
- activase
-
5\'-deoxyadenosyl
-
dual-phase
- hypophosphite
-
knappe
- benzylsuccinate
-
embden-meyerhof-parnas
- biotechnology
- nutrition
Reaction
Synonyms
AF_1449, formate acetyltransferase, PFL, PFL I, Pfl1, PflB, phosphotransferase system enzyme I, pyruvate formate lyase, pyruvate formate-lyase, pyruvate-formate lyase, pyruvate:formate lyase, pyruvic formate-lyase
ECTree
2.3.1.54 formate C-acetyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.3.1.54 - formate C-acetyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + formate
CoA + pyruvate
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-
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?
CoA + pyruvate
acetyl-CoA + formate
step in the mitochondrial pathway, overview
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-
?
CoA + pyruvate
acetyl-CoA + formate
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anaerobic growth under nitrogen, 37°C, pH 7.0, extract enzyme reactions measured at room temperature
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-
?
CoA + pyruvate
acetyl-CoA + formate
-
metabolic regulation and networking, overview
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-
?
CoA + pyruvate
acetyl-CoA + formate
Shewanella oneidensis MR-1 / ATCC 700550
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metabolic regulation and networking, overview
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-
?
CoA + pyruvate
acetyl-CoA + formate
formate is an important methyl group donor for anabolic pathway through the formation of folate derivates, formate supply improves Streptococcus thermophilus growth in milk
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-
?
CoA + pyruvate
acetyl-CoA + formate
formate is an important methyl group donor for anabolic pathway through the formation of folate derivates, formate supply improves Streptococcus thermophilus growth in milk
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-
?
pyruvate + CoA
acetyl-CoA + formate
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required for synthesis of C1 units in anabolism
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-
r
pyruvate + CoA
acetyl-CoA + formate
-
required for synthesis of C1 units in anabolism
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-
?
pyruvate + CoA
acetyl-CoA + formate
-
required for synthesis of C1 units in anabolism
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-
r
pyruvate + CoA
acetyl-CoA + formate
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physiological function is both anabolic and catabolic
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-
r
pyruvate + CoA
acetyl-CoA + formate
-
required for synthesis of C1 units in anabolism
-
-
?
pyruvate + CoA
acetyl-CoA + formate
-
required for synthesis of C1 units in anabolism
-
-
?
pyruvate + CoA
acetyl-CoA + formate
-
required for synthesis of C1 units in anabolism
-
-
r
pyruvate + CoA
acetyl-CoA + formate
required for synthesis of C1 units in anabolism
-
-
?
pyruvate + CoA
acetyl-CoA + formate
-
required for synthesis of C1 units in anabolism
-
-
?
pyruvate + CoA
acetyl-CoA + formate
-
catabolic function, leading to production of ATP
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-
?
pyruvate + CoA
acetyl-CoA + formate
-
catabolic function, leading to production of ATP
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-
ir, r
pyruvate + CoA
acetyl-CoA + formate
-
-
-
-
?
pyruvate + CoA
acetyl-CoA + formate
-
central reaction in the anaerobic metabolism
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-
r
pyruvate + CoA
acetyl-CoA + formate
-
key enzyme of the glucose fermentation route in anaerobically growing cells
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-
?
pyruvate + CoA
acetyl-CoA + formate
-
key enzyme of the glucose fermentation route in anaerobically growing cells
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-
r
pyruvate + CoA
acetyl-CoA + formate
key enzyme of the glucose fermentation route in anaerobically growing cells
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-
?
pyruvate + CoA
acetyl-CoA + formate
-
acetyl-CoA for ATP synthesis in catabolism
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-
ir, r
pyruvate + CoA
acetyl-CoA + formate
-
catabolic function, leading to production of ATP
-
-
?
pyruvate + CoA
acetyl-CoA + formate
-
catabolic function, leading to production of ATP
-
-
ir, r
pyruvate + CoA
acetyl-CoA + formate
-
main enzyme competing for pyruvate under anaerobic conditions
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-
r
pyruvate + CoA
acetyl-CoA + formate
-
-
-
-
r
pyruvate + CoA
acetyl-CoA + formate
-
catabolic function, leading to production of ATP
-
-
?
pyruvate + CoA
acetyl-CoA + formate
-
catabolic function, leading to production of ATP
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-
ir
pyruvate + CoA
formate + acetyl-CoA
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mixed-acid fermentation, necessary for growth in xylose minimal medium under anaerobic conditions
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r
additional information
?
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-
The product of yfiD gene is similar to pyruvate formate-lyase activase and it has been reported to activate PFL by replacing the glycyl radical domain, overview, the YfiD protein contributes to the pyruvate formate-lyase flux in the Escherichia coli arcA mutant strain, but not in the wild-type strain
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-
?
additional information
?
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pyruvate formate-lyase interacts directly with the formate channel FocA to regulate formate translocation, molecular modeling of the FocA-PflB complex, the N-terminus of FocA is important for interaction with enzyme PflB
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?
additional information
?
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pyruvate formate-lyase interacts directly with the formate channel FocA to regulate formate translocation, molecular modeling of the FocA-PflB complex, the N-terminus of FocA is important for interaction with enzyme PflB
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?
additional information
?
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hydrogen is formed from pyruvate by multiple parallel pathways, one pathway involves formate as an intermediate, pyruvate-formate lyase, and formate-hydrogen lyase, comprised of HydA hydrogenase and formate dehydrogenase, and a formate-independent pathway involving pyruvate dehydrogenase, the expression of pflB paralleled the expression of hydA and hyaB
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-
?
additional information
?
-
Shewanella oneidensis MR-1 / ATCC 700550
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hydrogen is formed from pyruvate by multiple parallel pathways, one pathway involves formate as an intermediate, pyruvate-formate lyase, and formate-hydrogen lyase, comprised of HydA hydrogenase and formate dehydrogenase, and a formate-independent pathway involving pyruvate dehydrogenase, the expression of pflB paralleled the expression of hydA and hyaB
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-
?
additional information
?
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analysis of the cytosolic proteome involving the enzyme, proteome profile
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-
?
additional information
?
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analysis of the cytosolic proteome involving the enzyme, proteome profile
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-
?
additional information
?
-
analysis of the cytosolic proteome involving the enzyme, proteome profile
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-
?
