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Literature summary for 2.3.1.54 extracted from
- Theoretical study of the suicide inhibition mechanism of the enzyme pyruvate formate lyase by methacrylate (2005), J. Am. Chem. Soc., 127, 6902-6909.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| methacrylate | suicide inhibition mechanism, possibly involving also Arg176 and Arg435, binds to Cys419, modeling, overview | Escherichia coli |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CoA + pyruvate | Escherichia coli | - |
acetyl-CoA + formate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| acetyl-CoA + formate = CoA + pyruvate | catalytic mechanism involving residues Gly734, Cys418 and Cys419, transition state, modeling, overview | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CoA + pyruvate | - |
Escherichia coli | acetyl-CoA + formate | - |
? | |
| CoA + pyruvate | the reaction involves Cys418 and Cys419 | Escherichia coli | acetyl-CoA + formate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| pyruvate formate lyase | - |
Escherichia coli |
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