2.1.1.49: amine N-methyltransferase

This is an abbreviated version!
For detailed information about amine N-methyltransferase, go to the full flat file.

Reaction

Synonyms

aromatic alkylamine-N-methyltransferase, arylamine N-methyltransferase, EC 2.1.1.81, methyltransferase, tryptamine, nicotine N-methyltransferase, tryptamine methyltransferase, tryptamine N-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.49 amine N-methyltransferase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
25	AA Sequence
1	CAS Registry Number
4	Cofactor
2	Inhibitors
2	Ki Value [mM]
19	KM Value [mM]
4	Localization
2	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
11	Organism
3	Pathway
1	PDB ID
4	pH Optimum
2	pH Range
2	pH Stability
3	Purification (Commentary)
1	Reaction
1	Reaction Type
7	Reference
15	Source Tissue
14	Specific Activity [micromol/min/mg]
3	Storage Stability
34	Substrates and Products (Substrate)
4	Subunits
7	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
14	Turnover Number [1/s]

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 2.1.1.49 - amine N-methyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(R)-isosalsoline + methyl group donor

N-methyl-(R)-isosalsoline + demethylated methyl group donor

Bos taurus

-

-

441355

N-methyl-(R)-isosalsoline is enzymatically formed in liver and can be transported into the brain from blood, it may act as neurotransmitter

441355

?

S-adenosyl-L-methionine + an amine

S-adenosyl-L-homocysteine + an N-methylamine

2 entries

S-adenosyl-L-methionine + an amine

S-adenosyl-L-homocysteine + an N-methylamine

Oryctolagus cuniculus

-

enzymes participate in detoxication, recycling of drugs after initial demethylation

441354

-

-

?

S-adenosyl-L-methionine + an amine

S-adenosyl-L-homocysteine + an N-methylamine

Rattus norvegicus

-

xenobiotic biotransforming enzyme, enzyme is leaked easily into the blood stream due to an increased membrane permeability of hepatocytes caused by cholestasis

441356

-

-

?