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2.1.1.49: amine N-methyltransferase

This is an abbreviated version!
For detailed information about amine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.49

Reaction

S-adenosyl-L-methionine
+
an amine
=
S-adenosyl-L-homocysteine
 +
a methylated amine

Synonyms

aromatic alkylamine-N-methyltransferase, arylamine N-methyltransferase, EC 2.1.1.81, methyltransferase, tryptamine, nicotine N-methyltransferase, tryptamine methyltransferase, tryptamine N-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.49 amine N-methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.49 - amine N-methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-isosalsoline + methyl group donor
N-methyl-(R)-isosalsoline + demethylated methyl group donor
show the reaction diagram
-
-
N-methyl-(R)-isosalsoline is enzymatically formed in liver and can be transported into the brain from blood, it may act as neurotransmitter
?
S-adenosyl-L-methionine + 1,2,3,4-tetrahydroisoquinoline
S-adenosyl-L-homocysteine + N-methyl-1,2,3,4-tetrahydroisoquinoline
show the reaction diagram
-
amine N-methyltransferase A
-
?
S-adenosyl-L-methionine + 5-methyloxytryptamine
?
show the reaction diagram
-
higher activity with transferase A
-
-
?
S-adenosyl-L-methionine + 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
?
show the reaction diagram
-
substrate with highest apparent kcat
-
-
?
S-adenosyl-L-methionine + alpha-N-methyltryptamine
S-adenosyl-L-homocysteine + alpha,alpha-N,N-dimethyltryptamine
show the reaction diagram
S-adenosyl-L-methionine + an amine
S-adenosyl-L-homocysteine + an N-methylamine
show the reaction diagram
S-adenosyl-L-methionine + aniline
S-adenosyl-L-homocysteine + N-methylaniline
show the reaction diagram
-
poor substrate
-
-
?
S-adenosyl-L-methionine + anisidine
?
show the reaction diagram
-
higher activity with transferase B
-
-
?
S-adenosyl-L-methionine + beta-phenylethylamine
?
show the reaction diagram
-
5-methyltetrahydrofolate can replace S-adenosyl-L-methionine as methyl donor
-
-
?
S-adenosyl-L-methionine + desmethylimipramine
S-adenosyl-L-homocysteine + imipramine
show the reaction diagram
S-adenosyl-L-methionine + imidazole
?
show the reaction diagram
-
higher activity with transferase A
-
-
?
S-adenosyl-L-methionine + isosalsoline
S-adenosyl-L-homocysteine + N-methylisosalsoline
show the reaction diagram
-
isosalsoline is identical with 7-hydroxy-6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline, stereospecific N-methylation by amine N-methyltransferase A, (+)-(R)-enantiomer is preferentially methylated
-
?
S-adenosyl-L-methionine + N-methylbutylamine
S-adenosyl-L-homocysteine + N,N-dimethylbutylamine
show the reaction diagram
-
only transferase A
-
-
?
S-adenosyl-L-methionine + N-methylcyclohexylamine
S-adenosyl-L-homocysteine + N,N-dimethylcyclohexylamine
show the reaction diagram
-
only transferase A
-
-
?
S-adenosyl-L-methionine + N-methyltryptamine
S-adenosyl-L-homocysteine + N,N-dimethyltryptamine
show the reaction diagram
S-adenosyl-L-methionine + phenyltetrahydropyridine
?
show the reaction diagram
-
higher activity with transferase A
-
-
?
S-adenosyl-L-methionine + pyrazole
?
show the reaction diagram
-
higher activity with transferase A
-
-
?
S-adenosyl-L-methionine + salsolidine
S-adenosyl-L-homocysteine + N-methylsalsolidine
show the reaction diagram
-
salsolidine is identical with 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline, stereospecific N-methylation by amine N-methyltransferase A, (-)-(S)-enantiomer is preferentially methylated
-
?
S-adenosyl-L-methionine + tryptamine
S-adenosyl-L-homocysteine + alpha-N-methyltryptamine
show the reaction diagram
additional information
?
-