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2.1.1.44: L-histidine Nalpha-methyltransferase

This is an abbreviated version!
For detailed information about L-histidine Nalpha-methyltransferase, go to the full flat file.

Reaction

3 S-adenosyl-L-methionine +

L-histidine
= 3 S-adenosyl-L-homocysteine +
hercynine

Synonyms

dimethylhistidine methyltransferase, EgtD, histidine-alpha-N-methyltransferase, methyltransferase, histidine Nalpha-

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.44 L-histidine Nalpha-methyltransferase

Engineering

Engineering on EC 2.1.1.44 - L-histidine Nalpha-methyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E285A
active site mutation, change the substrate specificity and transforms the histidine-methyltransferase towards a tryptophan-methyltransferase
M252A/E285A
active site mutation, change the substrate specificity and transforms the histidine-methyltransferase towards a tryptophan-methyltransferase
E285A
-
active site mutation, change the substrate specificity and transforms the histidine-methyltransferase towards a tryptophan-methyltransferase
-
M252A/E285A
-
active site mutation, change the substrate specificity and transforms the histidine-methyltransferase towards a tryptophan-methyltransferase
-