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2.1.1.37: DNA (cytosine-5-)-methyltransferase

This is an abbreviated version!
For detailed information about DNA (cytosine-5-)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.37

Reaction

S-adenosyl-L-methionine
+
DNA containing cytosine
=
S-adenosyl-L-homocysteine
 +
DNA containing 5-methylcytosine

Synonyms

5-cytosine DNA methyltransferase, C5 MTase, C5-MTase, CG recognizing DNA methyltransferase SssI, CMT1, CMT3, cytosine 5-methyltransferase, cytosine carbon 5 DNA methyltransferase, cytosine DNA methylase, cytosine DNA methyltransferase, cytosine DNA MTase, cytosine-5 methyltransferase, cytosine-specific DNA methyltransferase, DCM, DCMT, deoxyribonucleate methylase, deoxyribonucleate methyltransferase, deoxyribonucleic (cytosine-5-)-methyltransferase, deoxyribonucleic acid (cytosine-5-)-methyltransferase, deoxyribonucleic acid methylase, deoxyribonucleic acid methyltransferase, deoxyribonucleic acid modification methylase, deoxyribonucleic methylase, DMT1, DNA (cytosine-5) methyltransferase, DNA (cytosine-5)-methyltransferase 1, DNA (cytosine-5)-methyltransferase 2, DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3B, DNA (cytosine-5-)-methyltransferase 3A, DNA (cytosine-C5) methyltransferase, DNA 5-cytosine methylase, DNA cytosine C(5)-methyltransferase, DNA cytosine c5 methylase, DNA cytosine methylase, DNA cytosine methyltransferase, DNA cytosine-5 methyltransferase 1, DNA cytosine-5-methyltransferase 1, DNA cytosine-5-methyltransferase 3A, DNA cytosine-5-methyltransferase 3B, DNA methylase, DNA methyltransferase, DNA methyltransferase 1, DNA methyltransferase 3a, DNA methyltransferase-1, DNA MTase, DNA transmethylase, DNA-cytosine 5-methylase, DNA-cytosine methyltransferase, DNA-methyltransferase, DNMT, Dnmt1, Dnmt1 DNA-(cytosine-C5)-methyltransferase, DNMT1 methyltransferase, Dnmt1o, Dnmt2, Dnmt3, Dnmt3a, DNMT3B, DNMT3b2, DNMTB, DRM1/2, EC 2.1.1.73, EcoRI methylase, EcoRII DNA-cytosine methylase, EhMeth, hDNMT1, hhaIM, HpaII, M.BssHII, M.BsuRIa, M.BsuRIb, M.EcoHK31l, M.HhaI, M.HhaIII, M.MpeI, M.MspI, M.SsoII, M.Ssp6803I, M.SssI, MarII, MET1, MET1B, methylphosphotriester-DNA methyltransferase, methyltransferase, deoxyribonucleate, More, MspI DNA methyltransferase, MYPE4940, NSUN2, Nt-DRM1, SinI DNA methyltransferase, SsoII, ssoIIM, SSSI, sssIM, ssssIM, type II DNA methylase, Z2389, Zmt3

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.37 DNA (cytosine-5-)-methyltransferase

KI Value

KI Value on EC 2.1.1.37 - DNA (cytosine-5-)-methyltransferase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00689
(-)-epigallocatechin-3-gallate
-
substrate: poly(dI-dC)/poly(dI-dC)
0.016 - 0.037
5'-(3-aminopropylthio)-5'-deoxyadenosine
0.013 - 0.23
5'-(3-carboxypropylthio)-5'-deoxyadenosine
0.002
asCEBPA-1 RNA
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.00009 - 0.00043
asCEBPA-2 RNA
-
0.00092
asCEPA-1HPE RNA
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.000135
asCEPA-2HPE RNA
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.000269
miR-127-3p
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.002458
miR-145-5p
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.001031
miR-146a-5p
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.000028
miR-155-5p
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.000463
miR-16-5p
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.000317
miR-17-5p
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.003323
miR-19b-3p
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.000561
miR-20a-5p
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.001291
miR-21-5p
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.000298
miR-373-5p
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.001602
miR-9-3p
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.000493
miR-9-5p
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.000476
miR-92a-1-5p
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.00165
miR-92a-3p
substrate (CMeGG-CCG)12, pH 8.0, 37°C
-
0.044 - 0.069
S-(2'-deoxy-b -D-ribofuranosyladenosin-5'-yl)-L-homocysteine
0.0081 - 0.032
S-(N6 -benzoyladenosin-5'-yl)-L-homocysteine
0.059 - 0.29
S-adenosin-5'-yl-L-homocysteine methylamide
0.000015 - 0.00033
S-adenosyl-L-homocysteine
0.027
S-cytid-5'-yl-L-homocysteine
-
additional information
additional information
inhibition by mechanism-based inhibitors and kinetics, detailed overview
-