Information on EC 2.1.1.37 - DNA (cytosine-5-)-methyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.1.1.37
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RECOMMENDED NAME
GeneOntology No.
DNA (cytosine-5-)-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
methionine metabolism
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Cysteine and methionine metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9037-42-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
AAV
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
Bacillus subtilis phage PHI3T
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Manually annotated by BRENDA team
Bacillus subtilis phage rho11S
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
cellular organism
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
strain K12
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
Frog virus 3 FV3
FV3
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
Lymphocystis disease virus 1 FLDV
FLDV
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Manually annotated by BRENDA team
enzyme M.BspRI
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Manually annotated by BRENDA team
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1094058 A+, 1094148 A+, 1094241 A+, 1094256 A+, 1094273 A+, 1094281 A+, 1094296 A+, 1094353 A+, 1094378 A+, 1094418 A+, 1094437 A+, 1094463 A+, 1094468 A+, 1094471 A+, 1094490 A+, 1094535 A+, 1094580 A+, 1094587 A+, 1094588 A+, 1094623 A+, 1094627 A+, 1094643 A+, 1094648 A+, 1094657 A+, 1094670 A+, 1263862 A+, 1327789 A+, 1327829 A+, 1328179 A+, 1405356 A+, 1540861 A+, 1877898 A+, 1877971 A+, 1877983 A+, 1878073 A+, 1878104 A+, 1878140 A+, 1878175 A+, 1878250 A+, 1878271 A+, 1878276 A+, 1878381 A+, 1878401 A+, 1878505 A+, 1878507 A+, 1878510 A+, 1878553 A+, 1878592 A+, 1878689 A+, 1878698 A+, 1878715 A+, 1878733 A+, 1878798 A+, 1878824 A+, 1878856 A+, 1878857 A+, 1878872 A+, 1878939 A+, 1878966 A+, 1878971 A+, 1879025 A+, 1879034 A+, 2131024 A+, 2148542 A+, 2291140 A+, 2291255 A+, 2291256 A+, 2291261 A+, 2291305 A+, 2291309 A+, 2291367 A+, 2291432 A+, 2291457 A+, 2291478 A+, 2291498 A+, 2291509 A+, 2291515 A+, 2291517 A+, 2291554 A+, 2291573 A+, 2291588 A+, 2291595 A+, 2291613 A+, 2291636 A+, 2291648 A+, 2291682 A+, 2291700 A+, 2291717 A+, 2291735 A+, 2291740 A+, 2291744 A+, 2291745 A+, 2291746 A+, 2335522 A+, 2500487 A+, 2638252 A+, 2654467 A+, 2660265 A+, 2681772 A+, 2864046 A+, 2900722 A+, 2900733 A+, 2900739 A+, 2900757 A+, 2900766 A+, 2900776 A+, 2900902 A+, 2900917 A+, 2900930 A+, 2900959 A+, 2901121 A+, 2901134 A+, 2901189 A+, 2901313 A+, 2901351 A+, 2901466 A+, 2901518 A+, 2901544 A+, 2901580 A+, 2901601 A+, 2901637 A+, 2901657 A+, 2901682 A+, 2901746 A+, 2901776 A+, 2901796 A+, 2901849 A+, 2901857 A+, 2901871 A+, 2901894 A+, 2901902 A+, 2901925 A+, 2901926 A+, 2901939 A+, 2901940 A+, 734682 A+, 925034 A+, 1075494 A++, 1094048 A++, 1094057 A++, 1094138 A++, 1094174 A++, 1094182 A++, 1094214 A++, 1094243 A++, 1094248 A++, 1094286 A++, 1094287 A++, 1094308 A++, 1094368 A++, 1094381 A++, 1094397 A++, 1094483 A++, 1672959 A++, 1877939 A++, 1877975 A++, 1878009 A++, 1878028 A++, 1878055 A++, 1878064 A++, 1878068 A++, 1878069 A++, 1878184 A++, 1878253 A++, 1878751 A++, 1878758 A++, 2172456 A++, 2291086 A++, 2291134 A++, 2291152 A++, 2291155 A++, 2291166 A++, 2291172 A++, 2291186 A++, 2291199 A++, 2291278 A++, 2291281 A++, 2291316 A++, 2291342 A++, 2291344 A++, 2291369 A++, 2291373 A++, 2291374 A++, 2291380 A++, 2291447 A++, 2291537 A++, 2291591 A++, 2291610 A++, 2291618 A++, 2291643 A++, 2291654 A++, 2291690 A++, 2457897 A++, 2897251 A++, 2900715 A++, 2900768 A++, 2901002 A++, 2901010 A++, 2901066 A++, 2901309 A++, 2901379 A++, 2901620 A++, 2901754 A++, 659933 A++, 708586 A++, 736018 A++, 1094109 A++, 1094225 A++, 1094229 A++, 1094261 A++, 1094299 A++, 1094380 A++, 1094502 A++, 1555150 A++, 1877925 A++, 1877944 A++, 1878013 A++, 1878020 A++, 1878067 A++, 1878103 A++, 1878119 A++, 1878129 A++, 1878311 A++, 1878359 A++, 1878621 A++, 1878752 A++, 1878763 A++, 1878837 A++, 1878855 A++, 1878871 A++, 2291065 A++, 2291133 A++, 2291159 A++, 2291180 A++, 2291215 A++, 2291293 A++, 2291304 A++, 2291317 A++, 2291320 A++, 2291535 A++, 2291640 A++, 2291647 A++, 2327787 A++, 2384771 A++, 2457945 A++, 2511012 A++, 2598275 A++, 2681779 A++, 2900716 A++, 2900859 A++, 2900984 A++, 2901061 A++, 2901072 A++, 2901253 A++, 2901318 A++, 2901321 A++, 2901435 A++, 2901503 A++, 2901553 A++, 2901610 A++, 2901668 A++, 2901785 A++, 2901825 A++, 2901846 A++, 1094369 A+++, 1094405 A+++, 1094459 A+++, 1094575 A+++, 1094578 A+++, 1094634 A+++, 1094667 A+++, 1094167 A++++, 1094175 A++++, 1094188 A++++, 1094345 A++++, 1094363 A++++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
strain 158-1 contains MarII, an isoschizomer of the HhaI DNA methyltransferase, gene Marth_orf138
UniProt
Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
protozoa
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
quail
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Automatic Mining of ENzyme DAta
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1094015 A+, 1094016 A+, 1094018 A+, 1094020 A+, 1094021 A+, 1094023 A+, 1094233 A+, 1094356 A+, 1094538 A+, 1094610 A+, 1094656 A+, 1095855 A+, 1328160 A+, 1339563 A+, 1369950 A+, 1708676 A+, 1836298 A+, 1877892 A+, 1877954 A+, 1878091 A+, 1878192 A+, 1878335 A+, 1878407 A+, 1878444 A+, 1878477 A+, 1878513 A+, 1878562 A+, 1878580 A+, 1878633 A+, 1878651 A+, 1878746 A+, 1878760 A+, 1878792 A+, 1878794 A+, 1878803 A+, 1878835 A+, 1878845 A+, 1878902 A+, 1878927 A+, 1878952 A+, 1878994 A+, 1879000 A+, 2291522 A+, 2291589 A+, 2291624 A+, 2291706 A+, 2390942 A+, 2489500 A+, 2511023 A+, 2687499 A+, 2732396 A+, 2894459 A+, 2900692 A+, 2900805 A+, 2900843 A+, 2900871 A+, 2900895 A+, 2901201 A+, 2901270 A+, 2901392 A+, 2901513 A+, 2901690 A+, 2901694 A+, 2901709 A+, 2901762 A+, 2901784 A+, 2901790 A+, 705915 A+, 1093999 A++, 1094214 A++, 1094290 A++, 1094527 A++, 1369735 A++, 1877885 A++, 1877889 A++, 1877891 A++, 1877911 A++, 1877949 A++, 1878148 A++, 1878880 A++, 1878930 A++, 1878963 A++, 2291076 A++, 2291080 A++, 2291081 A++, 2291085 A++, 2291596 A++, 2488011 A++, 2699761 A++, 2900714 A++, 2900720 A++, 2901023 A++, 2901684 A++, 485276 A++, 485278 A++, 1339711 A++, 1873285 A++, 1877874 A++, 1877888 A++, 1877918 A++, 1877925 A++, 1878026 A++, 1878027 A++, 1878134 A++, 1878145 A++, 1878393 A++, 1878496 A++, 1878764 A++, 1878946 A++, 2291070 A++, 2291073 A++, 2291082 A++, 2291084 A++, 2291610 A++, 2408215 A++, 2558180 A++, 2900705 A++, 2900888 A++, 2901154 A++, 2901482 A++, 2901683 A++, 2901754 A++, 2901791 A++, 2901839 A++, 1094056 A+++, 1094060 A+++, 1094069 A+++, 1094099 A+++, 1094115 A+++, 1094116 A+++, 1094414 A+++, 1094511 A+++, 1094533 A+++, 1094607 A+++, 1092420 A++++, 1093985 A++++, 1094004 A++++, 1094008 A++++, 1094026 A++++, 1094036 A++++, 1094046 A++++, 1094225 A++++, 1094283 A++++, 1094569 A++++, 485298 A++++, 912940 A++++
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Automatic Mining of ENzyme DAta
salamander
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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UniProt
Manually annotated by BRENDA team
strain MW-1
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Manually annotated by BRENDA team
strain MW-1
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
toad
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
yeasts
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Automatic Mining of ENzyme DAta
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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DNMT1 is crucial for cell survival, as in its absence cells undergo arrest in G1/S, a DNA damage response is triggered, and the cells undergo mitotic catastrophe
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
show the reaction diagram
DNA fragment RPS + S-adenosyl-L-methionine
DNA fragment RPS containing 5-methylcytosine + S-adenosyl-L-homocysteine
show the reaction diagram
RPS is a repetitive hypermethylated DNA fragment from Petunia hybrida. CG methylation, CNG methylation, and CNN methylation. MET1 maintains CG methylation, and DRM1/2 and CMT3 act redundantly to enforce non-CG methylation, unusual cooperative activity of all three DNA methyltransferases is therefore required for maintenance of both CG and non-CG methylation in RPS. Arabidopsis thaliana does not contain any RPS homologues. Methylation at the CCmTGG site also requires DRM1/2, MET1, and, to a lesser extent, CMT3
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plasmid pSDTV28 + S-adenosyl-L-methionine
plasmid pSDTV28 containing 5-methylcytosine + S-adenosyl-L-homocysteine
show the reaction diagram
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poly(dG-mdC)-poly(dG-dC) + S-adenosyl-L-methionine
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show the reaction diagram
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poly(dI-mdC)-poly(dI-dC) + S-adenosyl-L-methionine
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show the reaction diagram
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S-adenosyl-L-methionine + CpA
S-adenosyl-L-homocysteine + CpA containing 5-methylcytosine
show the reaction diagram
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S-adenosyl-L-methionine + CpG
S-adenosyl-L-homocysteine + CpG containing 5-methylcytosine
show the reaction diagram
S-adenosyl-L-methionine + CpT
S-adenosyl-L-homocysteine + CpT containing 5-methylcytosine
show the reaction diagram
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?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
show the reaction diagram
S-adenosyl-L-methionine + poly(dI-dC)/poly(dI-dC)
S-adenosyl-L-homocysteine + poly(dI-dC)/poly(dI-dC) containing 5-methylcytosine
show the reaction diagram
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?
additional information
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