Information on EC 2.1.1.37 - DNA (cytosine-5-)-methyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
2.1.1.37
-
RECOMMENDED NAME
GeneOntology No.
DNA (cytosine-5-)-methyltransferase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
methyl group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Cysteine and methionine metabolism
-
Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5-cytosine DNA methyltransferase
-
-
C5 MTase
-
-
C5-MTase
-
-
-
-
C5-MTase
-
-
CG recognizing DNA methyltransferase SssI
-
-
CMT1
Q8H854
-
cytosine 5-methyltransferase
-
-
-
-
cytosine carbon 5 DNA methyltransferase
P26358
-
cytosine DNA methylase
-
-
-
-
cytosine DNA methyltransferase
-
-
-
-
cytosine DNA methyltransferase
P26358
-
cytosine DNA methyltransferase
B1Q3J6, B9FJ44, Q10C15, Q10SU5, Q8H854, Q8SBB4
-
cytosine DNA methyltransferase
-
-
cytosine DNA MTase
B1Q3J6, B9FJ44, Q10C15, Q10SU5, Q8H854, Q8SBB4
-
cytosine-5 methyltransferase
-
-
cytosine-specific DNA methyltransferase
-
-
-
-
DCMT
-
-
-
-
deoxyribonucleate methylase
-
-
-
-
deoxyribonucleate methyltransferase
-
-
-
-
deoxyribonucleic (cytosine-5-)-methyltransferase
-
-
-
-
deoxyribonucleic acid (cytosine-5-)-methyltransferase
-
-
-
-
deoxyribonucleic acid methylase
-
-
-
-
deoxyribonucleic acid methyltransferase
-
-
-
-
deoxyribonucleic acid modification methylase
-
-
-
-
deoxyribonucleic methylase
-
-
-
-
DMT1
-
-
DNA (cytosine-5) methyltransferase
-
-
DNA (cytosine-5)-methyltransferase 1
-
-
DNA (cytosine-5)-methyltransferase 1
-
-
DNA (cytosine-5)-methyltransferase 3A
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-
DNA (cytosine-5)-methyltransferase 3B
-
-
DNA (cytosine-5-)-methyltransferase 3A
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-
DNA (cytosine-C5) methyltransferase
-
-
DNA 5-cytosine methylase
-
-
-
-
DNA cytosine C(5)-methyltransferase
P13864
-
DNA cytosine c5 methylase
-
-
-
-
DNA cytosine methylase
-
-
-
-
DNA cytosine methyltransferase
Q8X8S5
-
DNA cytosine methyltransferase
-
-
DNA cytosine-5 methyltransferase 1
-
-
DNA cytosine-5-methyltransferase 1
-
-
DNA cytosine-5-methyltransferase 3A
-
-
DNA cytosine-5-methyltransferase 3B
-
-
DNA methylase
-
-
-
-
DNA methyltransferase
-
-
-
-
DNA methyltransferase
-
-
DNA methyltransferase
Adeno-associated virus AAV
-
-
-
DNA methyltransferase
-
-
DNA methyltransferase
-
-
DNA methyltransferase
Frog virus 3 FV3
-
-
-
DNA methyltransferase
-
-
DNA methyltransferase
P26358
-
DNA methyltransferase
Q9UBC3
-
DNA methyltransferase
Lymphocystis disease virus 1 FLDV
-
-
-
DNA methyltransferase
B1Q3J6, Q7Y1I7
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DNA methyltransferase 1
-
-
DNA methyltransferase 1
P26358
-
DNA methyltransferase 1
-
-
DNA methyltransferase 3a
Q9UBC3
-
DNA methyltransferase-1
Q24K09
-
DNA MTase
B1Q3J6, Q7Y1I7
-
DNA transmethylase
-
-
-
-
DNA-cytosine 5-methylase
-
-
-
-
DNA-cytosine methyltransferase
-
-
-
-
DNA-methyltransferase
C4P086, C4P087
-
DNMT
Adeno-associated virus AAV
-
-
-
DNMT
-
-
DNMT
Frog virus 3 FV3
-
-
-
DNMT
-
-
DNMT
P26358, Q9UBC3
-
DNMT
Lymphocystis disease virus 1 FLDV
-
-
-
Dnmt1
Q24K09
-
Dnmt1
P26358
isoform
Dnmt1 DNA-(cytosine-C5)-methyltransferase
P13864
-
DNMT1 methyltransferase
-
-
Dnmt1o
-
-
Dnmt2
-
-
Dnmt2
O55055
-
Dnmt3a
Q9UBC3
-
Dnmt3a
Q9Y6K1
-
Dnmt3a
-
-
DNMT3B
Q9UBC3
-
DNMT3b2
Q9UBC3
isoform
DNMTB
-
-
DRM1/2
Q94F88
-
EcoRI methylase
-
-
-
-
EcoRII DNA-cytosine methylase
-
-
EcoRII DNA-cytosine methylase
Escherichia coli K12
-
-
-
hDNMT1
-
-
M.BsuRIa
-
-
M.BsuRIb
-
-
M.EcoHK31l
-
-
M.HhaIII
P20589
-
M.MspI
-
-
M.Ssp6803I
-
-
M.SssI
-
-
M.SssI
Spirulina sp. MW-1
-
-
-
MarII
Mycoplasma arthritidis 158-1
B3PM23
-
-
MET1
C4P086, C4P087
-
MET1B
B1Q3J6
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methylphosphotriester-DNA methyltransferase
-
-
-
-
MspI DNA methyltransferase
-
-
P26358 {SwissProt}
P26358
-
SinI DNA methyltransferase
-
-
type II DNA methylase
-
-
-
-
Z2389
Q8X8S5
-
Zmt3
Q10SU5
-
methyltransferase, deoxyribonucleate
-
-
-
-
additional information
cellular organism
-
this is a large group of enzymes most of which, with enzymes of similar site specificity listed as EC 3.1.21.3, 4 or 5, form so-called 'restriction-modification systems'. A complete listing of all these enzymes has been produced by R.J. Roberts, this list is updated annually
additional information
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the enzyme belongs to the DNA methyltransferase, DNMT, enzyme family
additional information
-
the enzyme belongs to the DNA methyltransferases, Dnmt, family of enzymes that methylates DNA at the C5 position of cytosine residues
additional information
B1Q3J6, B9FJ44, Q10C15, Q10SU5
in plants exist four main subfamilies of MTases
additional information
Q8H854
four main subfamilies of MTases exist in plants
additional information
Q8SBB4
in plants exist four main subfamilies of MTases
CAS REGISTRY NUMBER
COMMENTARY
9037-42-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Adeno-associated virus AAV
AAV
-
-
Manually annotated by BRENDA team
Bacillus subtilis phage PHI3T
-
-
-
Manually annotated by BRENDA team
Bacillus subtilis phage rho11S
-
-
-
Manually annotated by BRENDA team
female cows
UniProt
Manually annotated by BRENDA team
cellular organism
-
-
-
Manually annotated by BRENDA team
isozymes Dnmt3a and Dnmt3b
-
-
Manually annotated by BRENDA team
strain EDL933, a O157:H7 strain, gene z2389, which is located within the genome of prophage CP-933R
UniProt
Manually annotated by BRENDA team
strain K12
-
-
Manually annotated by BRENDA team
strain W
-
-
Manually annotated by BRENDA team
Escherichia coli K12
strain K12
-
-
Manually annotated by BRENDA team
gene FaDRMa
UniProt
Manually annotated by BRENDA team
Frog virus 3 FV3
FV3
-
-
Manually annotated by BRENDA team
enzyme M.BssHII expressed as two isoforms: isoform I and isoform II
Uniprot
Manually annotated by BRENDA team
Geobacillus stearothermophilus H3
H3
Uniprot
Manually annotated by BRENDA team
enzyme M.HaeIII
-
-
Manually annotated by BRENDA team
enzyme M.HpaII
-
-
Manually annotated by BRENDA team
isozyme Dnmt1; isozyme Dnmt3b
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-
Manually annotated by BRENDA team
isozymes DNMT1 and DNMT3a
-
-
Manually annotated by BRENDA team
recombinant
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-
Manually annotated by BRENDA team
Lymphocystis disease virus 1 FLDV
FLDV
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-
Manually annotated by BRENDA team
enzyme M.BspRI
-
-
Manually annotated by BRENDA team
DNMT1
-
-
Manually annotated by BRENDA team
Dnmt3a
SwissProt
Manually annotated by BRENDA team
Dnmt3b
SwissProt
Manually annotated by BRENDA team
enzyme Dnmt3b
SwissProt
Manually annotated by BRENDA team
female ICR mice
-
-
Manually annotated by BRENDA team
recombinant, enzyme Dnmt3A
SwissProt
Manually annotated by BRENDA team
recombinant, enzyme Dnmt3B
SwissProt
Manually annotated by BRENDA team
Swiss albino male mice
-
-
Manually annotated by BRENDA team
strain 158-1 contains MarII, an isoschizomer of the HhaI DNA methyltransferase, gene Marth_orf138
UniProt
Manually annotated by BRENDA team
Mycoplasma arthritidis 158-1
strain 158-1 contains MarII, an isoschizomer of the HhaI DNA methyltransferase, gene Marth_orf138
UniProt
Manually annotated by BRENDA team
cv. Xanthi
-
-
Manually annotated by BRENDA team
CMT1; subsp. japonica, encodes a total of 10 genes that contain the highly conserved MTase catalytic domain
UniProt
Manually annotated by BRENDA team
L. cv Roncarolo
-
-
Manually annotated by BRENDA team
MET1-1; gene MET1-1
UniProt
Manually annotated by BRENDA team
MET1-2; genes MET1-2
UniProt
Manually annotated by BRENDA team
MET1B or MET1-2; subsp. japonica, encodes a total of 10 genes that contain the highly conserved MTase catalytic domain
UniProt
Manually annotated by BRENDA team
subsp. japonica, encodes a total of 10 genes that contain the highly conserved MTase catalytic domain
UniProt
Manually annotated by BRENDA team
Zmt3; subsp. japonica, encodes a total of 10 genes that contain the highly conserved MTase catalytic domain
UniProt
Manually annotated by BRENDA team
serovar Infantis
-
-
Manually annotated by BRENDA team
strain MW-1
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-
Manually annotated by BRENDA team
Spirulina sp. MW-1
strain MW-1
-
-
Manually annotated by BRENDA team
enzyme M.Sau961
-
-
Manually annotated by BRENDA team
strain PCC 6803, gene slr021
-
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
Mycoplasma penetrans (strain HF-2)
Crystallization/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
crystal structure of the cytosine-5-methyltransferase EhMeth at a resolution of 2.15 A is presented in complex with its reaction product S-adenosyl-L-homocysteine. In contrast to the human DNMT2 structure, the active site loop (residues 80-100) of EhMeth is well defined and clearly forms an alpha-helix
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crystal structures of HhaI methyltransferase complexed with cognate unmethylated or methylated DNA together with S-adenosyl-L-homocysteine
-