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2.1.1.37: DNA (cytosine-5-)-methyltransferase

This is an abbreviated version!
For detailed information about DNA (cytosine-5-)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.37

Reaction

S-adenosyl-L-methionine
+
DNA containing cytosine
=
S-adenosyl-L-homocysteine
 +
DNA containing 5-methylcytosine

Synonyms

5-cytosine DNA methyltransferase, C5 MTase, C5-MTase, CG recognizing DNA methyltransferase SssI, CMT1, CMT3, cytosine 5-methyltransferase, cytosine carbon 5 DNA methyltransferase, cytosine DNA methylase, cytosine DNA methyltransferase, cytosine DNA MTase, cytosine-5 methyltransferase, cytosine-specific DNA methyltransferase, DCM, DCMT, deoxyribonucleate methylase, deoxyribonucleate methyltransferase, deoxyribonucleic (cytosine-5-)-methyltransferase, deoxyribonucleic acid (cytosine-5-)-methyltransferase, deoxyribonucleic acid methylase, deoxyribonucleic acid methyltransferase, deoxyribonucleic acid modification methylase, deoxyribonucleic methylase, DMT1, DNA (cytosine-5) methyltransferase, DNA (cytosine-5)-methyltransferase 1, DNA (cytosine-5)-methyltransferase 2, DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3B, DNA (cytosine-5-)-methyltransferase 3A, DNA (cytosine-C5) methyltransferase, DNA 5-cytosine methylase, DNA cytosine C(5)-methyltransferase, DNA cytosine c5 methylase, DNA cytosine methylase, DNA cytosine methyltransferase, DNA cytosine-5 methyltransferase 1, DNA cytosine-5-methyltransferase 1, DNA cytosine-5-methyltransferase 3A, DNA cytosine-5-methyltransferase 3B, DNA methylase, DNA methyltransferase, DNA methyltransferase 1, DNA methyltransferase 3a, DNA methyltransferase-1, DNA MTase, DNA transmethylase, DNA-cytosine 5-methylase, DNA-cytosine methyltransferase, DNA-methyltransferase, DNMT, Dnmt1, Dnmt1 DNA-(cytosine-C5)-methyltransferase, DNMT1 methyltransferase, Dnmt1o, Dnmt2, Dnmt3, Dnmt3a, DNMT3B, DNMT3b2, DNMTB, DRM1/2, EC 2.1.1.73, EcoRI methylase, EcoRII DNA-cytosine methylase, EhMeth, hDNMT1, hhaIM, HpaII, M.BssHII, M.BsuRIa, M.BsuRIb, M.EcoHK31l, M.HhaI, M.HhaIII, M.MpeI, M.MspI, M.SsoII, M.Ssp6803I, M.SssI, MarII, MET1, MET1B, methylphosphotriester-DNA methyltransferase, methyltransferase, deoxyribonucleate, More, MspI DNA methyltransferase, MYPE4940, NSUN2, Nt-DRM1, SinI DNA methyltransferase, SsoII, ssoIIM, SSSI, sssIM, ssssIM, type II DNA methylase, Z2389, Zmt3

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.37 DNA (cytosine-5-)-methyltransferase

Cloned

Cloned on EC 2.1.1.37 - DNA (cytosine-5-)-methyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
co-expression of Dnmt3b with Tdg or Mbd4 in HEK293T cells
construction of pDIM-N7 and pAR for expression of M.EcoHK31I fragments, construction of pDIM-N7 Tyr123-alpha and pAR beta-Tyr456 plasmids for combinatorial library, the recombinantly expressed M.EcoHK31I enzyme is functional in vivo when the two fragments are encoded as separate genes, overview
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construction of three hybrid methyltransferases, containing the intact N-terminus of the murine Dnmt1 and most of the coding sequences from M.HhaI (GCGC), M.HpaII (CCGG) or M.SssI (CG). The hybrids are biologically active when expressed in a baculovirus system and show the specificity of the parental C-terminal domain
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DNA (cytosine C5) methyltransferase-1, fused to an amino-terminal hexahistidine tag, is expressed by infecting Spodoptera frugiperda cells for 46 h with a recombinant baculovirus carrying the DNA (cytosine-C5)methyltransferase-1 cDNA
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DNMT1 and DNMT3a, expression analysis of the isozymes in salivary gland neoplasmata
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DNMT1, DNA and amino acid sequence determination and analysis, expression of wild-type and mutants in Escherichia coli
-
DNMT1, overexpression of HA-tagged CXXC deletion DNMT1 mutant, expression of wild-type and deletion mutant enzymes in COS-7 cells and Escherichia coli, CXXC deleted DNMT1, mutant DNMT1DELTACXXC, is localized on replication foci
DNMT2 controls retrotransposon silencing and 2R and 3R telomere integrity in somatic cells, overview
-
enzyme MET1 is encoded by DRM, i.e domain-rearranged methyltransferase, genes FaDRMa, FaDRMb and FaDRMc, DNA and amino acid sequence determination and analysis, DRMa expression analysis and phylogenetic analysis, overview
enzyme MET1 is encoded by DRM, i.e domain-rearranged methyltransferase, genes FaDRMa, FaDRMb and FaDRMc, DNA and amino acid sequence determination and analysis, DRMb expression analysis and phylogenetic analysis, overview
expressed in Escherichia coli
-
expressed in High Five insect cells
expression analysis by RT-PCR
expression in a baculovirus/Sf9 cell system
expression in Escherichia coli
expression in Escherichia coli and Bacillus stearothermophilus, expressed as N-terminal fusion at ATC149-151 or ATG344-345 to histidine taggs
expression in insect cell
expression in Sf9 cell
expression in Sf9 cells
expression of His6-tagged SssI in Escherichia coli strain ER1821
-
expression of the enzyme by using a protein splicing fusion partner in a baculovirus expression vector
-
expression of wild-type and mutant enzymes in Escherichia coli
-
gene Marth_orf138, DNA and amino acid sequence determination and analysis, expression in Escherichia coli
gene MET1-1, DNA and amino acid sequence determination and analysis
gene MET1-2, DNA and amino acid sequence determination and analysis
gene MET1B or MET1-2, phylogenetic analysis, microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
B1Q3J6, B9FJ44, Q10C15, Q10SU5, Q8H854, Q8SBB4
gene OsCMT1, phylogenetic analysis, microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
B1Q3J6, B9FJ44, Q10C15, Q10SU5, Q8H854, Q8SBB4
gene slr021, expression in Nicotiana tabacum cv. Petit Havana young leaves, analysis of DNA methylation in the plastid genome of transgeneic plants, overview
-
gene z2389, located within the genome of prophage CP-933R, sequence comparisonsn, expression of His6-tagged enzyme under the control of an arabinose-inducible promoter in Escherichia coli strain BW25113
gene Zmt3, phylogenetic analysis, microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
B1Q3J6, B9FJ44, Q10C15, Q10SU5, Q8H854, Q8SBB4
M.HhaI overexpression in Escherichia coli strain ER1727
-
overexpression of Dnmt3a and Dnmt3b
-
phylogenetic analysis, microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
B1Q3J6, B9FJ44, Q10C15, Q10SU5, Q8H854, Q8SBB4
somatic Dnmt1 from liver, expression analysis of somatic and oocyte Dnmt1, recombinant expression in NIH3T3 cells
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transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus, phenotype, overview
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