1.5.1.25: thiomorpholine-carboxylate dehydrogenase
This is an abbreviated version!
For detailed information about thiomorpholine-carboxylate dehydrogenase, go to the full flat file.
Word Map on EC 1.5.1.25
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1.5.1.25
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thyroid
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nadph-dependent
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bioavailability
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cerebral
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unsaturated
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ovine
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l-cystathionine
- 1.5.1.25
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thyroid
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nadph-dependent
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bioavailability
- cerebral
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unsaturated
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ovine
- l-cystathionine
Reaction
Synonyms
CRYM, CtBP, cytosolic thyroid hormone binding protein, DELTA1-piperideine-2-carboxylate reductase, ketimine reductase, ketimine-reducing enzyme, KR/CRYM/CTBP, More, mu-crystallin, P2C reductase, PLP-dependent amino acid gamma-substitution enzyme, PYCR2, Pyr2C reductase, reductase, ketimine, THBP, thyroid hormone binding protein, Thyroid hormone-binding protein
ECTree
1.5.1.25 thiomorpholine-carboxylate dehydrogenaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.5.1.25 - thiomorpholine-carboxylate dehydrogenase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
aminoethyl cysteine ketimine + NADPH + H+
thiomorpholine-3-carboxylate
-
-
-
?
lanthionine ketimine + NADPH + H+
thiomorpholine-3,5-dicarboxylate
-
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
1,4-thiomorpholine-3-carboxylate + NADP+
thiomorpholine 3-carboxylate + NAD(P)+
3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H+
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
-
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
-
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
-
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
-
-
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
-
-
?
S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+
1,4-thiomorpholine-3-carboxylate + NADP+
-
-
-
-
?
thiomorpholine 3-carboxylate + NAD(P)+
3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H+
-
-
-
?
thiomorpholine 3-carboxylate + NAD(P)+
3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H+
-
-
-
?
additional information
?
-
-
the non-sulfur substrates exist in equilibrium with open chain forms at low acidic pH. At neutral pH, they exist predominantly as the enzymatically favorable cyclic ketimine form (in which the ring double bond is in the C=N form), while sulfur-containing cyclic ketimine substrates exist predominantly as the enzymatically unfavorable enamine form (in which the ring double bond is in the C=C form) at neutral pH
-
-
?
additional information
?
-
-
the non-sulfur substrates exist in equilibrium with open chain forms at low acidic pH. At neutral pH, they exist predominantly as the enzymatically favorable cyclic ketimine form (in which the ring double bond is in the C=N form), while sulfur-containing cyclic ketimine substrates exist predominantly as the enzymatically unfavorable enamine form (in which the ring double bond is in the C=C form) at neutral pH
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-
?
additional information
?
-
reciprocal relationship between thyroid hormone binding and DELTA1-piperideine-2-carboxylate (P2C) binding to ketimine reductase
-
-
-
additional information
?
-
-
the non-sulfur substrates exist in equilibrium with openchain forms at low acidic pH. At neutral pH, they exist predominantly as the enzymatically favorable cyclic ketimine form (in which the ring double bond is in the C=N form), while sulfur-containing cyclic ketimine substrates exist predominantly as the enzymatically unfavorable enamine form (in which the ring double bond is in the C=C form) at neutral pH
-
-
?
additional information
?
-
reciprocal relationship between thyroid hormone binding and DELTA1-piperideine-2-carboxylate (P2C) binding to ketimine reductase
-
-
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