1.5.1.2: pyrroline-5-carboxylate reductase

This is an abbreviated version!
For detailed information about pyrroline-5-carboxylate reductase, go to the full flat file.

Word Map on EC 1.5.1.2

1.5.1.2

ornithine

cutis

prodh

hyperprolinemia

progeroid

wrinkled

medicine

proline-dependent

hypomyelinating

p53-induced

aldh18a1

prolidase

Reaction

Synonyms

1-pyrroline-5-carboxylate reductase, aldimine reductase, DELTA1-pyrroline-5-carboxylate reductase, DELTA1-pyrroline-5-carboxylate reductase 2, L-proline oxidase, L-proline-NAD(P)+ 5-oxidoreductase, L-proline:NAD(P)+ 5-oxidoreductase, MTR_7g090160, NADPH-L-DELTA'-pyrroline carboxylic acid reductase, P5C reductase, P5CDH, P5CR, PO, POX, PROC, proline oxidase, Pycr1, PYCR2, Pyr5C reductase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylate reductase, reductase, pyrroline-5-carboxylate, TcCLB.509207.90

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.2 pyrroline-5-carboxylate reductase

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Results	in table
8	Activating Compound
45977	AA Sequence
9	Application
1	CAS Registry Number
23	Cloned(Commentary)
92	Cofactor
8	Crystallization (Commentary)
535	Disease/ Diagnostics
4	Expression
12	General Information
6	General Stability
67	IC50 Value
175	Inhibitors
33	kcat/KM [mM/s]
11	Ki Value [mM]
127	KM Value [mM]
25	Localization
14	Metals/Ions
27	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
116	Organism
9	Pathway
128	PDB ID
41	pH Optimum
7	pH Range
3	pH Stability
1	pI Value
9	Protein Variants
32	Purification (Commentary)
2	Reaction
27	Reaction Type
100	Reference
1	Renatured (Commentary)
82	Source Tissue
42	Specific Activity [micromol/min/mg]
12	Storage Stability
140	Substrates and Products (Substrate)
18	Subunits
70	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
17	Temperature Stability [°C]
52	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.5.1.2 - pyrroline-5-carboxylate reductase

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0.00039 - 0.00048

([[(3,5-dibromophenyl)methyl]amino]methylene)bis(phosphonic acid)

2 entries

0.00074 - 0.00078

([[(3,5-dichlorophenyl)methyl]amino]methylene)bis(phosphonic acid)

2 entries

0.00078

([[3,5-bis(trifluoromethyl)phenyl]amino]methanediyl)bis(phosphonic acid)

Streptococcus pyogenes

pH 7.5-8.0, at 37°C

723917

1.187

2,3-dichlorophenylhydroxymethylenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.488

2-(2,3-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.431

2-(2,3-dichlorophenylamino)ethylidenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

1.639

2-(2,6-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.763

2-(2,6-dichlorophenylamino)ethylidenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.463

2-(3,5-di(trifluoromethyl)phenylamino)ethylidenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.082

2-(3,5-dichlorophenylamino)ethylidenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

1.914

2-(3,5-dimethylphenyl)-1-hydroxyethylidenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.386

2-(3,5-dimethylphenylamino)ethylidenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.488

2-(4-benzylphenylamino)ethylidenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

2.071

2-(4-chlorophenyl)-1-hydroxyethylidenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.413

3,5-di(trifluoromethyl)phenylaminomethylenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.054

3,5-dibromophenylaminomethylenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.719

3,5-difluorophenylaminomethylenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

1.409

3,5-dimethylphenylhydroxymethylenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.547

3-carbamoylphenylaminomethylenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

1.618

3-chlorophenylaminomethylenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.852

4-benzylphenylaminomethylenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.325

4-benzylphenylhydroxymethylenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.0087 - 0.234

4-bromopargyline

2 entries

0.684

5,6,7,8-tetrahydro-2-naphthylaminomethylenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

0.485 - 0.704

Cl-

2 entries

1.19

cyclopentanecarboxylate

Homo sapiens

P32322

pH 7.8, temperature not specified in the publication

763270

EDTA

Streptococcus pyogenes

at pH 7.5 and 37°C

723922

1.887

indan-5-ylaminomethylenebisphosphonic acid

Arabidopsis thaliana

in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C

725183

200

KCl

Arabidopsis thaliana

F4K884

cofactor NADH, pH 7.8, 35°C

741069

1.72 - 107

L-proline

3 entries

2.25

L-tetrahydro-2-furoic acid

Homo sapiens

P32322

pH 7.8, temperature not specified in the publication

763270

0.44

L-thiazolidine-2-carboxylate

Homo sapiens

P32322

pH 7.8, temperature not specified in the publication

763270

0.6

L-thiazolidine-4-carboxylate

Homo sapiens

P32322

pH 7.8, temperature not specified in the publication

763270

0.1

N-formyl-L-proline

Homo sapiens

P32322

pH 7.8, temperature not specified in the publication

763270

130 - 1144

NaCl

3 entries

1.4 - 7.4

NAD+

2 entries

0.032 - 22.6

NADP+

3 entries

0.045

NADPH

Trypanosoma cruzi

Q4DH60

pH 7, 28°C

762709

0.081 - 10

Pargyline

2 entries

0.00087 - 0.335

[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)

2 entries

0.012

[[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)

Streptococcus pyogenes

pH 7.5-8.0, at 37°C

723917

0.0027

[[(2,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)

Streptococcus pyogenes

pH 7.5-8.0, at 37°C

723917

0.00088 - 0.45

[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)

2 entries

0.00039

[[(3,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)

Streptococcus pyogenes

pH 7.5-8.0, at 37°C

723917

0.00022

[[(3,5-dibromophenyl)amino]methanediyl]bis(phosphonic acid)

Streptococcus pyogenes

pH 7.5-8.0, at 37°C

723917

0.00022 - 0.134

[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)

2 entries

0.0256 - 1.245

[[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid)

2 entries

0.0009

[[(3-chlorophenyl)amino]methanediyl]bis(phosphonic acid)

Streptococcus pyogenes

pH 7.5-8.0, at 37°C

723917

0.00041

[[(4-benzylphenyl)amino]methanediyl]bis(phosphonic acid)

Streptococcus pyogenes

pH 7.5-8.0, at 37°C

723917

0.0014 - 0.97

[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)

2 entries