Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-dichlorophenylhydroxymethylenebisphosphonic acid | - |
Arabidopsis thaliana | |
2-(2,3-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid | - |
Arabidopsis thaliana | |
2-(2,3-dichlorophenylamino)ethylidenebisphosphonic acid | - |
Arabidopsis thaliana | |
2-(2,6-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid | - |
Arabidopsis thaliana | |
2-(2,6-dichlorophenylamino)ethylidenebisphosphonic acid | - |
Arabidopsis thaliana | |
2-(3,5-di(trifluoromethyl)phenylamino)ethylidenebisphosphonic acid | - |
Arabidopsis thaliana | |
2-(3,5-dichlorophenylamino)ethylidenebisphosphonic acid | - |
Arabidopsis thaliana | |
2-(3,5-dimethylphenyl)-1-hydroxyethylidenebisphosphonic acid | - |
Arabidopsis thaliana | |
2-(3,5-dimethylphenylamino)ethylidenebisphosphonic acid | - |
Arabidopsis thaliana | |
2-(4-benzylphenylamino)ethylidenebisphosphonic acid | - |
Arabidopsis thaliana | |
2-(4-chlorophenyl)-1-hydroxyethylidenebisphosphonic acid | - |
Arabidopsis thaliana | |
3,5-di(trifluoromethyl)phenylaminomethylenebisphosphonic acid | - |
Arabidopsis thaliana | |
3,5-dibromophenylaminomethylenebisphosphonic acid | - |
Arabidopsis thaliana | |
3,5-difluorophenylaminomethylenebisphosphonic acid | - |
Arabidopsis thaliana | |
3,5-dimethylphenylhydroxymethylenebisphosphonic acid | - |
Arabidopsis thaliana | |
3-carbamoylphenylaminomethylenebisphosphonic acid | - |
Arabidopsis thaliana | |
3-chlorophenylaminomethylenebisphosphonic acid | - |
Arabidopsis thaliana | |
4-benzylphenylaminomethylenebisphosphonic acid | - |
Arabidopsis thaliana | |
4-benzylphenylhydroxymethylenebisphosphonic acid | - |
Arabidopsis thaliana | |
5,6,7,8-tetrahydro-2-naphthylaminomethylenebisphosphonic acid | - |
Arabidopsis thaliana | |
indan-5-ylaminomethylenebisphosphonic acid | - |
Arabidopsis thaliana | |
[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | - |
Arabidopsis thaliana | |
[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | - |
Arabidopsis thaliana | |
[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | - |
Arabidopsis thaliana | |
[[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid) | - |
Arabidopsis thaliana | |
[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid) | - |
Arabidopsis thaliana |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate precipitation, anion exchange column chromatography, and gel filtration | Arabidopsis thaliana |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-pyrroline-5-carboxylate + NADH + H+ | - |
Arabidopsis thaliana | L-proline + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DELTA1-pyrroline-5-carboxylate reductase | - |
Arabidopsis thaliana |
P5C reductase | - |
Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Arabidopsis thaliana | |
NADPH | - |
Arabidopsis thaliana |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.054 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 3,5-dibromophenylaminomethylenebisphosphonic acid | |
0.082 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 2-(3,5-dichlorophenylamino)ethylidenebisphosphonic acid | |
0.134 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | [[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | |
0.325 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 4-benzylphenylhydroxymethylenebisphosphonic acid | |
0.335 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | [[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | |
0.386 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 2-(3,5-dimethylphenylamino)ethylidenebisphosphonic acid | |
0.413 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 3,5-di(trifluoromethyl)phenylaminomethylenebisphosphonic acid | |
0.431 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 2-(2,3-dichlorophenylamino)ethylidenebisphosphonic acid | |
0.45 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | [[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid) | |
0.463 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 2-(3,5-di(trifluoromethyl)phenylamino)ethylidenebisphosphonic acid | |
0.488 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 2-(2,3-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid | |
0.488 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 2-(4-benzylphenylamino)ethylidenebisphosphonic acid | |
0.547 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 3-carbamoylphenylaminomethylenebisphosphonic acid | |
0.684 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 5,6,7,8-tetrahydro-2-naphthylaminomethylenebisphosphonic acid | |
0.719 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 3,5-difluorophenylaminomethylenebisphosphonic acid | |
0.763 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 2-(2,6-dichlorophenylamino)ethylidenebisphosphonic acid | |
0.852 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 4-benzylphenylaminomethylenebisphosphonic acid | |
0.97 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | [[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid) | |
1.187 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 2,3-dichlorophenylhydroxymethylenebisphosphonic acid | |
1.245 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | [[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid) | |
1.409 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 3,5-dimethylphenylhydroxymethylenebisphosphonic acid | |
1.618 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 3-chlorophenylaminomethylenebisphosphonic acid | |
1.639 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 2-(2,6-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid | |
1.887 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | indan-5-ylaminomethylenebisphosphonic acid | |
1.914 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 2-(3,5-dimethylphenyl)-1-hydroxyethylidenebisphosphonic acid | |
2.071 | - |
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C | Arabidopsis thaliana | 2-(4-chlorophenyl)-1-hydroxyethylidenebisphosphonic acid |