1.14.14.1: unspecific monooxygenase This is an abbreviated version! For detailed information about unspecific monooxygenase, go to the full flat file .
Reaction
RH +
[reduced NADPH-hemoprotein reductase] +
O2 =
ROH +
[oxidized NADPH-hemoprotein reductase] +
H2O
Synonyms 3AH15, 6 beta-hydroxylase, 6-beta-testosterone hydroxylase, 7-alkoxycoumarin O-dealkylase, 7-ethoxycoumarin-O-deethylase, 7-ethoxyresorufin-O-deethylase, AA omega-hydroxylase, Aldehyde oxygenase, Arachidonic acid epoxygenase, aromatase, aryl hydrocarbon hydroxylase, aryl-4-monooxygenase, BG04_163, BM3, BPH, Brain aromatase, class IV cytochrome P450 monooxygenase, clavine oxidase, CLOA, Clone PF26, Clone PF3/46, Coumarin 7-hydroxylase, CP2D6, Cyp, CYP monooxygenase, CYP102, CYP102 monooxygenase, CYP1027H1, CYP102A1, CYP102A2, CYP102A3, CYP102A7, CYP102B1, CYP106, CYP107, CYP1074A2, CYP109, CYP116B3, CYP116B4, CYP116B46, CYP134, CYP150A20, CYP152, CYP154H1, CYP19, CYP197, CYP1A, CYP1A1, CYP1A2, CYP1A3, CYP1B1, CYP24A1, CYP27A1, CYP28A5, CYP2A3, CYP2A6, CYP2B, CYP2B4, CYP2B6, CYP2C11, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP305A1, CYP3A, CYP3A1, CYP3A4, CYP3A5, CYP3A7, CYP4, CYP4502F4, CYP4A, CYP4A4, CYP4A6, CYP4A7, CYP4AA1, CYP4E2, CYP4F, CYP4F2, CYP4F3A, CYP4F3B, CYP5035A2, CYP5035A3, CYP5035A5, CYP5035C1, CYP5036A1, CYP5036A3, CYP5037B2, CYP505D1, CYP505D2, CYP505D3, CYP505D4, CYP51, CYP512B5, CYP512H1, CYP5136A2, CYP5136A3, CYP5136A5, CYP5139A1, CYP5141A1, CYP5141D1, CYP5142A3, CYP5142C1, CYP5144A3, CYP5144A7, CYP5144A9, CYP5144C7, CYP5144D4, CYP5145A3, CYP5147A1, CYP5150B1, CYP53A15, CYP53C2, CYP53D2, CYP5A1, CYP63A2, CYP6B1, CYP6B1v1, CYP6B1V1/CYP6B1V2/ CYP6B1V3, CYP6B3V1/CYP6B3V2, CYP6B4V1/CYP6B4V2, CYP6B5V1, CYP714D1, CYP82E2, CYP82E3, CYP82E4v1, CYP82E4v2, CYP8A1, CYP9F2, CYPIA1, CYPIA2, CYPIA4, CYPIA5, CYPIB1, CYPIIA1, CYPIIA10, CYPIIA11, CYPIIA12, CYPIIA13, CYPIIA2, CYPIIA3, CYPIIA4, CYPIIA5, CYPIIA6, CYPIIA7, CYPIIA8, CYPIIA9, CYPIIB1, CYPIIB10, CYPIIB11, CYPIIB12, CYPIIB19, CYPIIB2, CYPIIB20, CYPIIB3, CYPIIB4, CYPIIB5, CYPIIB6, CYPIIB9, CYPIIC1, CYPIIC10, CYPIIC11, CYPIIC12, CYPIIC13, CYPIIC14, CYPIIC15, CYPIIC16, CYPIIC17, CYPIIC18, CYPIIC19, CYPIIC2, CYPIIC20, CYPIIC21, CYPIIC22, CYPIIC23, CYPIIC24, CYPIIC25, CYPIIC26, CYPIIC27, CYPIIC28, CYPIIC29, CYPIIC3, CYPIIC30, CYPIIC31, CYPIIC37, CYPIIC38, CYPIIC39, CYPIIC4, CYPIIC40, CYPIIC41, CYPIIC42, CYPIIC5, CYPIIC6, CYPIIC7, CYPIIC8, CYPIIC9, CYPIID1, CYPIID10, CYPIID11, CYPIID14, CYPIID15, CYPIID16, CYPIID17, CYPIID18, CYPIID19, CYPIID2, CYPIID3, CYPIID4, CYPIID5, CYPIID6, CYPIID9, CYPIIE1, CYPIIF1, CYPIIF3, CYPIIF4, CYPIIG1, CYPIIH1, CYPIIH2, CYPIIIA1, CYPIIIA10, CYPIIIA11, CYPIIIA12, CYPIIIA13, CYPIIIA14, CYPIIIA15, CYPIIIA16, CYPIIIA17, CYPIIIA18, CYPIIIA19, CYPIIIA2, CYPIIIA21, CYPIIIA24, CYPIIIA25, CYPIIIA27, CYPIIIA28, CYPIIIA29, CYPIIIA3, CYPIIIA30, CYPIIIA31, CYPIIIA5, CYPIIIA6, CYPIIIA7, CYPIIIA8, CYPIIIA9, CYPIIJ1, CYPIIJ2, CYPIIJ3, CYPIIJ5, CYPIIJ6, CYPIIK1, CYPIIK3, CYPIIK4, CYPIIL1, CYPIIM1, CYPIVA4, CYPIVA8, CYPIVB1, CYPIVC1, CYPIVF1, CYPIVF11, CYPIVF12, CYPIVF4, CYPIVF5, CYPIVF6, CYPIVF8, CYPVIA1, CYPVIB1, CYPVIB2, CYPVIB4, CYPVIB5, CYPVIB6, CYPVIB7, CYPXIX, CYPXIXA1, CYPXIXA2, CYPXIXA3, Cyt P450, cytochrome P-450 4 enzyme, cytochrome P-450 BM3, cytochrome P-450 monooxygenase, cytochrome P450 2B4, cytochrome P450 3A, cytochrome P450 3A4, cytochrome P450 aromatase, cytochrome P450 BM3, cytochrome P450 monooxygenase, cytochrome P450 monooxygenase 116B3, cytochrome P450 monooxygenase 2A6, cytochrome P450 monooxygenase 2C8, cytochrome P450 monooxygenase 2C9, cytochrome P450 monooxygenase 3A4, cytochrome P450 monooxygenase pc-2, cytochrome P450 monooxygenase pc-4, cytochrome P450 monooxygenase pc-5, cytochrome P450 monooxygenase pc-6, cytochrome P450 monooxygenase PC-foxy1, cytochrome P450 oxidoreductase, cytochrome P450 reductase, Cytochrome P450-D2, cytochrome P450-dependent monooxygenase, cytochrome P450-dependent monooxygenase 1A2, cytochrome P450-monooxygenase, cytochrome-P450 hydroxylase, DAH1, DAH2, Debrisoquine 4-hydroxylase, EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8, EC 1.99.1.1, ECOD, Ema, EROD, Estrogen synthetase, EUI, fatty acid hydroxylase, flavocytochrome P450BM-3, flavoprotein monooxygenase, flavoprotein-linked monooxygenase, FMO3, FraEuI1c_1415, FraEuI1c_2494, FraEuI1c_5334, GA 16a,17-epoxidase, GA-deactivating enzyme, Hepatic cytochrome P-450MC1, HLp, HMPREF1624_01477, IIA3, Isozyme 3A, Laurate omega-1 hydroxylase, Lauric acid omega-6-hydroxylase, liver cytochrome P450-dependent monooxygenase, LMC1, Mephenytoin 4-hydroxylase, MFO, microsomal monooxygenase, microsomal P-450, mixed function oxygenase, monooxygenase 3, monooxygenase P450 BM-3, More, N-demethylase, nicotine oxidase, O-demethylase, OLF2, Olfactive, Os05g0482400 protein, Ovarian aromatase, oxygenase, flavoprotein-linked mono-, P(3)450, P-448, P-450 PHPAH1, P-450(M-1), P-450-MK2, P-450AROM, P-450IB, P-450IIIAM1, P-450MC, P-450MP, P-450UT, P1-88, P24, P450, P450 17-alpha, P450 19A1, P450 1A1, P450 1A2, P450 1B1, P450 2A6, P450 2B6, P450 2C19, P450 2C9, P450 2D-29/2D-35, P450 2D6, P450 2E1, P450 2J2, P450 3A4, P450 4A11, P450 4F2, P450 BM3, P450 CM3A-10, P450 DUT2, P450 FA, P450 FI, P450 form 3B, P450 form HP1, P450 HSM1, P450 HSM2, P450 HSM3, P450 HSM4, P450 IIB1, P450 IIC2, P450 LM4, P450 LM6, P450 LMC2, P450 MD, P450 monooxygenase, P450 MP-12/MP-20, P450 P49, P450 PB1, P450 PB4, P450 PBC1, P450 PBC2, P450 PBC3, P450 PBC4, P450 PCHP3, P450 PCHP7, P450 TCDDAA, P450 TCDDAHH, P450 type B2, P450 types B0 and B1, P450(I), P450-11A, P450-15-alpha, P450-15-COH, P450-16-alpha, P450-254C, P450-3C, P450-6B/29C, P450-A3, P450-AFB, P450-ALC, P450-BM3, P450-CMF1A, P450-CMF1B, P450-CMF2, P450-CMF3, P450-DB1, P450-DB2, P450-DB3, P450-DB4, P450-DB5, P450-HFLA, P450-HP, P450-IIA10, P450-IIA11, P450-IIA3.1, P450-IIA3.2, P450-IIA4, P450-KP1, P450-LM2, P450-MC1, P450-MC4, P450-MK1, P450-MKJ1, P450-MKMP13, P450-MKNF2, P450-NMB, P450-OLF1, P450-OLF3, P450-P1, P450-P2/P450-P3, P450-P3, P450-PB1 and P450-PB2, P450-PCN1, P450-PCN2, P450-PCN3, P450-PM4, P450-PP1, P450-PROS2, P4501A1, P450arom, P450cam, P450CB, P450CMEF, P450E, P450EF, P450F, P450H, P450I, P450IIC5, P450MT2, P450RAP, P450RLM6, P450s 3A, P450SMO, P52, PB15, PHP2, PHP3, PikC, PikC hydroxylase, Progesterone 21-hydroxylase, Prostaglandin omega-hydroxylase, PTF1, PTF2, S-mephenytoin 4-hydroxylase, Sam5, sertraline N-demethylase, SIAM614_30676, Steroid hormones 7-alpha-hydroxylase, Testosterone 15-alpha-hydroxylase, Testosterone 16-alpha hydroxylase, Testosterone 6-beta-hydroxylase, Testosterone 7-alpha-hydroxylase, xenobiotic monooxygenase
ECTree
Natural Substrates Products
Natural Substrates Products on EC 1.14.14.1 - unspecific monooxygenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
4-(methylnitrosamino)-1-(3pyridyl)-1-butanone + [reduced NADPH-hemoprotein reductase] + O2
?
-
nicotine oxidase activity of CYP2A6, activates the tobacco-derived carcinogens to mutagenic products
-
-
?
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
7-hydroxycoumarin + [oxidized NADPH-hemoprotein reductase] + H2O + ?
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
?
7-ethoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2
?
7-methoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
7-hydroxycoumarin + [oxidized NADPH-hemoprotein reductase] + ?
-
-
-
-
?
aflatoxin B1 + [reduced NADPH-hemoprotein reductase] + O2
?
-
i.e. AFB1, bioactivation of the carcinogenic mycotoxin to a toxic compound, although not acutely toxic at low concentrations, AFB1 had significant chronic effects, including protracted development, increased mortality, decreased pupation rate, and reduced pupal weight, sensitivity varies with developmental stage, whereas intermediate concentrations causes complete mortality in first instars, this same concentration has no detectable adverse effects on larvae encountering AFB1 in fifth instar. These compounds owe their toxicity to their ability to form irreversible adducts to nucleic acids with the concomitant inhibition of DNA replication and DNA-dependent transcription, mortality, overview
-
-
?
aminopyrine + [reduced NADPH-hemoprotein reductase] + O2
? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
arachidonic acid + O2 + NADPH
20-hydroxyeicosatetraenoic acid + H2O + NADP+
avermectin + [reduced NADPH-hemoprotein reductase] + O2
4''-oxo-avermectin + [oxidized NADPH-hemoprotein reductase] + H2O
bentazon + [reduced NADPH-hemoprotein reductase] + O2
?
-
ring-hydroxylation
-
-
?
benzo-pyrene + [reduced NADPH-hemoprotein reductase] + O2
?
-
recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
?
diclofop + [reduced NADPH-hemoprotein reductase] + O2
?
-
ring-hydroxylation
-
-
?
elymoclavine + [reduced NADPH-hemoprotein reductase] + O2
paspalic acid + [oxidized NADPH-hemoprotein reductase] + H2O
giberellic acid GA4 + [reduced NADPH-hemoprotein reductase] + O2
16alpha,17-epoxy GA4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
the product is transformed further to 16,17-dihydro-16alpha,17-dihydroxy-GA4 in the plant
-
?
indane + [reduced NADPH-hemoprotein reductase] + O2
(S)-3-hydroxy-indane + [oxidized NADPH-hemoprotein reductase] + H2O
macrolide YC-17 + [reduced NADPH-hemoprotein reductase] + O2
methymycin + [oxidized NADPH-hemoprotein reductase] + H2O
-
Hydroxylation of C-10 position yield methymycin and of the C-12 neomethymycin. Hydroxylation at both positions yields novamethymycin.
-
-
?
macrolide YC-17 + [reduced NADPH-hemoprotein reductase] + O2
neomethymycin + [oxidized NADPH-hemoprotein reductase] + H2O
-
Hydroxylation of C-10 position yield methymycin and of the C-12 neomethymycin. Hydroxylation at both positions yields novamethymycin.
-
-
?
macrolide YC-17 + [reduced NADPH-hemoprotein reductase] + O2
novamethymycin + [oxidized NADPH-hemoprotein reductase] + H2O
-
Hydroxylation of C-10 position yield methymycin and of the C-12 neomethymycin. Hydroxylation at both positions yields novamethymycin.
-
-
?
metolachlor + [reduced NADPH-hemoprotein reductase] + O2
?
Sorghum sp.
-
de-ethylation
-
-
?
N'-nitrosonornicotine + [reduced NADPH-hemoprotein reductase] + O2
?
-
nicotine oxidase activity of CYP2A6, activates the tobacco-derived carcinogens to mutagenic products
-
-
?
narbomycin + [reduced NADPH-hemoprotein reductase] + O2
pikromycin + [oxidized NADPH-hemoprotein reductase] + H2O
-
the organism is a pikromycin producer
-
-
?
prostaglandin + [reduced NADPH-hemoprotein reductase] + O2
20-hydroxy-prostaglandin + [oxidized NADPH-hemoprotein reductase] + H2O
-
physiological functions are the metabolic inactivation of prostaglandins and the production of 20-hydroxyeicosatetraenoic acid, CYP4A4
-
-
?
quinine + [reduced NADPH-hemoprotein reductase] + O2
3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
-
in the microsomal membranes, CYP3A4 interacts with the NADPH-P450 reductase to receive electrons used in metabolism of drugs and xenobiotics. The heme unit in CYP3A4 is the catalytic center and electrons are transferred through reduced FMN to heme through electrostatic interactions
-
-
?
RH + [reduced NADPH-hemoprotein reductase] + O2
ROH + [oxidized NADPH-hemoprotein reductase] + H2O
sertraline + [reduced NADPH-hemoprotein reductase] + O2
demethylsertraline + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
tetralin + [reduced NADPH-hemoprotein reductase] + O2
(S)-4-hydroxy-tetralin + [oxidized NADPH-hemoprotein reductase] + H2O
additional information
?
-
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
7-hydroxycoumarin + [oxidized NADPH-hemoprotein reductase] + H2O + ?
-
wild-type enzyme and recombinant enzyme P4502B6 fused to yeast reductase and expressed in transgenic tobacco plants
-
-
?
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
7-hydroxycoumarin + [oxidized NADPH-hemoprotein reductase] + H2O + ?
-
wild-type enzyme and recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
-
-
?
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
7-hydroxycoumarin + [oxidized NADPH-hemoprotein reductase] + H2O + ?
-
-
-
-
?
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
?
-
7-ethoxycoumarin O-deethylation
-
-
?
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
?
-
7-ethoxycoumarin O-deethylation
-
-
?
7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2
?
-
7-ethoxycoumarin O-deethylation
-
-
?
7-ethoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2
?
-
7-ethoxyresorufin O-deethylation
-
-
?
7-ethoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2
?
-
7-ethoxyresorufin O-deethylation
-
-
?
7-ethoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2
?
-
7-ethoxyresorufin O-deethylation
-
-
?
aminopyrine + [reduced NADPH-hemoprotein reductase] + O2
? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
-
aminopyrene-N-demethylation
-
-
?
aminopyrine + [reduced NADPH-hemoprotein reductase] + O2
? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
-
aminopyrene-N-demethylation
-
-
?
aminopyrine + [reduced NADPH-hemoprotein reductase] + O2
? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
-
aminopyrene-N-demethylation
-
-
?
arachidonic acid + O2 + NADPH
20-hydroxyeicosatetraenoic acid + H2O + NADP+
-
-
i.e. 20-HETE, a potent constrictor of renal microvessels and inhibits Na+ reabsorption in the proximal tubule and thick ascending limb
-
?
arachidonic acid + O2 + NADPH
20-hydroxyeicosatetraenoic acid + H2O + NADP+
-
-
i.e. 20-HETE, a potent constrictor of renal microvessels and inhibits Na+ reabsorption in the proximal tubule and thick ascending limb
-
?
avermectin + [reduced NADPH-hemoprotein reductase] + O2
4''-oxo-avermectin + [oxidized NADPH-hemoprotein reductase] + H2O
-
4''-oxo-avermectin is a key intermediate in the manufacture of the agriculturally important insecticide emamectin benzoate from the natural product avermectin, overview
-
-
?
avermectin + [reduced NADPH-hemoprotein reductase] + O2
4''-oxo-avermectin + [oxidized NADPH-hemoprotein reductase] + H2O
-
4''-oxo-avermectin is a key intermediate in the manufacture of the agriculturally important insecticide emamectin benzoate from the natural product avermectin, overview
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
?
-
recombinant wild-type enzyme and enzyme mutant fused to yeast reductase expressed in transgenic potato plants
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
?
-
ring methyl-hydroxylation
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
?
-
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
?
-
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group, recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
?
-
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
?
-
a combination of oxidative N-demethylation and hydroxylation of the ring-methyl group
-
-
?
chlorotoluron + [reduced NADPH-hemoprotein reductase] + O2
?
-
ring methyl-hydroxylation
-
-
?
elymoclavine + [reduced NADPH-hemoprotein reductase] + O2
paspalic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
the product is the precursor for D-lysergic acid
-
?
elymoclavine + [reduced NADPH-hemoprotein reductase] + O2
paspalic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
the product is the precursor for D-lysergic acid
-
?
indane + [reduced NADPH-hemoprotein reductase] + O2
(S)-3-hydroxy-indane + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
indane + [reduced NADPH-hemoprotein reductase] + O2
(S)-3-hydroxy-indane + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
RH + [reduced NADPH-hemoprotein reductase] + O2
ROH + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
RH + [reduced NADPH-hemoprotein reductase] + O2
ROH + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
RH + [reduced NADPH-hemoprotein reductase] + O2
ROH + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
sertraline + [reduced NADPH-hemoprotein reductase] + O2
demethylsertraline + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
-
i.e. (1S,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a one-step oxidative N-demethylation
-
-
?
sertraline + [reduced NADPH-hemoprotein reductase] + O2
demethylsertraline + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
-
i.e. (1S,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a one-step oxidative N-demethylation
-
-
?
tetralin + [reduced NADPH-hemoprotein reductase] + O2
(S)-4-hydroxy-tetralin + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
tetralin + [reduced NADPH-hemoprotein reductase] + O2
(S)-4-hydroxy-tetralin + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
additional information
?
-
-
the enzyme possibly also catalyzes the oxidation of agroclavine, overview, the enzyme bridges the clavine and ergoline alkaloid pathways, it is critical in the ergot alkaloid gene cluster
-
-
?
additional information
?
-
-
the enzyme possibly also catalyzes the oxidation of agroclavine, overview, the enzyme bridges the clavine and ergoline alkaloid pathways, it is critical in the ergot alkaloid gene cluster
-
-
?
additional information
?
-
-
a xenobiotic-metabolizing cytochrome P450 monooxygenase that contributes extensively to drug and toxin metabolism, CYP3A4 is the predominant enzyme in the clearance of about 50% of therapeutic drugs
-
-
?
additional information
?
-
-
in humans, CYP3A4 appears to be the dominant CYP and contributes to over 60% of the metabolism of drugs, the Ah receptor is important in CYP1A1 regulation, a number of mechanisms occur to regulate CYP including enhancement of mRNA stability, modulation of heme degradation, enzyme phosphorylation, and protein-protein interactions
-
-
?
additional information
?
-
-
the cytochrome P-450 4, CYP4, family catalyze the omega-hydroxylation of fatty acids, metabolic regulation, overview
-
-
?
additional information
?
-
-
CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective
-
-
?
additional information
?
-
-
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
-
-
?
additional information
?
-
-
effect of toxification on hepaic metabolism and biotransformation enzyme levels, overview
-
-
?
additional information
?
-
-
effect of toxification on hepatic metabolism and biotransformation enzyme levels, overview
-
-
?
additional information
?
-
the concomitant down-regulation of P450arom and up-regulation of P45011beta are of pivotal importance to the sex change
-
-
?
additional information
?
-
-
the concomitant down-regulation of P450arom and up-regulation of P45011beta are of pivotal importance to the sex change
-
-
?
additional information
?
-
-
CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective
-
-
?
additional information
?
-
-
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
-
-
?
additional information
?
-
the enzyme demethylates nicotine to nornicotine, nornicotine serves as the precursor in the synthesis of the well characterized carcinogen N'-nitrosonornicotine during the curing and processing of tobacco
-
-
?
additional information
?
-
the enzyme demethylates nicotine to nornicotine, nornicotine serves as the precursor in the synthesis of the well characterized carcinogen N'-nitrosonornicotine during the curing and processing of tobacco
-
-
?
additional information
?
-
Q38Q86
the enzyme demethylates nicotine to nornicotine, nornicotine serves as the precursor in the synthesis of the well characterized carcinogen N'-nitrosonornicotine during the curing and processing of tobacco
-
-
?
additional information
?
-
the enzyme demethylates nicotine to nornicotine, nornicotine serves as the precursor in the synthesis of the well characterized carcinogen N'-nitrosonornicotine during the curing and processing of tobacco
-
-
?
additional information
?
-
-
the enzyme demethylates nicotine to nornicotine, nornicotine serves as the precursor in the synthesis of the well characterized carcinogen N'-nitrosonornicotine during the curing and processing of tobacco
-
-
?
additional information
?
-
EUI acts as a gibberellic acid inactivating enzyme, in eui mutant plans, the biological activity of GA4 is reduced, expression of Eui is tightly regulated during plant development with the stage-specific eui phenotypes, GA biosynthesis and catabolism pathways, overview, the enzyme negatively regulates gibberellic acid metabolism, mechanism, overview
-
-
?
additional information
?
-
-
EUI acts as a gibberellic acid inactivating enzyme, in eui mutant plans, the biological activity of GA4 is reduced, expression of Eui is tightly regulated during plant development with the stage-specific eui phenotypes, GA biosynthesis and catabolism pathways, overview, the enzyme negatively regulates gibberellic acid metabolism, mechanism, overview
-
-
?
additional information
?
-
-
the enzyme is involved in the biosynthesis of astaxanthin, overview
-
-
?
additional information
?
-
-
the enzyme is involved in the biosynthesis of astaxanthin, overview
-
-
?
additional information
?
-
-
mechanisms of secondary metabolism and oxidative biotransformation pathways in this model white rot fungus, overview
-
-
?
additional information
?
-
mechanisms of secondary metabolism and oxidative biotransformation pathways in this model white rot fungus, overview
-
-
?
additional information
?
-
mechanisms of secondary metabolism and oxidative biotransformation pathways in this model white rot fungus, overview
-
-
?
additional information
?
-
mechanisms of secondary metabolism and oxidative biotransformation pathways in this model white rot fungus, overview
-
-
?
additional information
?
-
mechanisms of secondary metabolism and oxidative biotransformation pathways in this model white rot fungus, overview
-
-
?
additional information
?
-
mechanisms of secondary metabolism and oxidative biotransformation pathways in this model white rot fungus, overview
-
-
?
additional information
?
-
-
mechanisms of secondary metabolism and oxidative biotransformation pathways in this model white rot fungus, overview
-
-
?
additional information
?
-
mechanisms of secondary metabolism and oxidative biotransformation pathways in this model white rot fungus, overview
-
-
?
additional information
?
-
mechanisms of secondary metabolism and oxidative biotransformation pathways in this model white rot fungus, overview
-
-
?
additional information
?
-
mechanisms of secondary metabolism and oxidative biotransformation pathways in this model white rot fungus, overview
-
-
?
additional information
?
-
mechanisms of secondary metabolism and oxidative biotransformation pathways in this model white rot fungus, overview
-
-
?
additional information
?
-
mechanisms of secondary metabolism and oxidative biotransformation pathways in this model white rot fungus, overview
-
-
?
additional information
?
-
-
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
-
-
?
additional information
?
-
-
no fluctuations between the light and dark periods under ad libitum and restricted feeding conditions, effects on P450 monooxygenase activities in male rats, overview
-
-
?
additional information
?
-
-
the cytochrome P-450 4, CYP4, family catalyze the omega-hydroxylation of fatty acids, metabolic regulation, overview, PPARalpha agonist increased the transcription activity of rat CYP4A1
-
-
?
additional information
?
-
-
CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective
-
-
?
additional information
?
-
-
YP116B3 catalyzes the dealkylation of 7-ethoxycoumarin and the hydroxylation of substituted and unsubstituted aromatics, overview
-
-
?
additional information
?
-
-
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
-
-
?
additional information
?
-
Sorghum sp.
-
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
-
-
?
additional information
?
-
-
the enzyme is involved in macrolide biosynthesis and performs unusual C4-hydroxylation
-
-
?
additional information
?
-
-
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
-
-
?
additional information
?
-
-
the enzyme catalyzes a wide range of reactions in secondary metabolism, overview, the enzyme is important in metabolism of herbicides, overview
-
-
?