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Literature summary for 1.14.14.1 extracted from

  • Zeng, R.S.; Niu, G.; Wen, Z.; Schuler, M.A.; Berenbaum, M.R.
    Toxicity of aflatoxin B1 to Helicoverpa zea and bioactivation by cytochrome P450 monooxygenases (2006), J. Chem. Ecol., 32, 1459-1471.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Phenobarbital induces the enzyme Helicoverpa zea

Inhibitors

Inhibitors Comment Organism Structure
piperonyl butoxide
-
Helicoverpa zea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aflatoxin B1 + [reduced NADPH-hemoprotein reductase] + O2 Helicoverpa zea i.e. AFB1, bioactivation of the carcinogenic mycotoxin to a toxic compound, although not acutely toxic at low concentrations, AFB1 had significant chronic effects, including protracted development, increased mortality, decreased pupation rate, and reduced pupal weight, sensitivity varies with developmental stage, whereas intermediate concentrations causes complete mortality in first instars, this same concentration has no detectable adverse effects on larvae encountering AFB1 in fifth instar. These compounds owe their toxicity to their ability to form irreversible adducts to nucleic acids with the concomitant inhibition of DNA replication and DNA-dependent transcription, mortality, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Helicoverpa zea
-
corn earworm
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Helicoverpa zea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aflatoxin B1 + [reduced NADPH-hemoprotein reductase] + O2
-
Helicoverpa zea ?
-
?
aflatoxin B1 + [reduced NADPH-hemoprotein reductase] + O2 i.e. AFB1, bioactivation of the carcinogenic mycotoxin to a toxic compound, although not acutely toxic at low concentrations, AFB1 had significant chronic effects, including protracted development, increased mortality, decreased pupation rate, and reduced pupal weight, sensitivity varies with developmental stage, whereas intermediate concentrations causes complete mortality in first instars, this same concentration has no detectable adverse effects on larvae encountering AFB1 in fifth instar. These compounds owe their toxicity to their ability to form irreversible adducts to nucleic acids with the concomitant inhibition of DNA replication and DNA-dependent transcription, mortality, overview Helicoverpa zea ?
-
?

Synonyms

Synonyms Comment Organism
cytochrome P450 monooxygenase
-
Helicoverpa zea

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Helicoverpa zea