Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Phenobarbital | induces the enzyme | Helicoverpa zea |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
piperonyl butoxide | - |
Helicoverpa zea |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
aflatoxin B1 + [reduced NADPH-hemoprotein reductase] + O2 | Helicoverpa zea | i.e. AFB1, bioactivation of the carcinogenic mycotoxin to a toxic compound, although not acutely toxic at low concentrations, AFB1 had significant chronic effects, including protracted development, increased mortality, decreased pupation rate, and reduced pupal weight, sensitivity varies with developmental stage, whereas intermediate concentrations causes complete mortality in first instars, this same concentration has no detectable adverse effects on larvae encountering AFB1 in fifth instar. These compounds owe their toxicity to their ability to form irreversible adducts to nucleic acids with the concomitant inhibition of DNA replication and DNA-dependent transcription, mortality, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Helicoverpa zea | - |
corn earworm | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Helicoverpa zea |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aflatoxin B1 + [reduced NADPH-hemoprotein reductase] + O2 | - |
Helicoverpa zea | ? | - |
? | |
aflatoxin B1 + [reduced NADPH-hemoprotein reductase] + O2 | i.e. AFB1, bioactivation of the carcinogenic mycotoxin to a toxic compound, although not acutely toxic at low concentrations, AFB1 had significant chronic effects, including protracted development, increased mortality, decreased pupation rate, and reduced pupal weight, sensitivity varies with developmental stage, whereas intermediate concentrations causes complete mortality in first instars, this same concentration has no detectable adverse effects on larvae encountering AFB1 in fifth instar. These compounds owe their toxicity to their ability to form irreversible adducts to nucleic acids with the concomitant inhibition of DNA replication and DNA-dependent transcription, mortality, overview | Helicoverpa zea | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cytochrome P450 monooxygenase | - |
Helicoverpa zea |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Helicoverpa zea |