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Literature summary for 1.14.14.1 extracted from
- High-performance liquid chromatography determination of N- and O-demethylase activities of chemicals in human liver microsomes: application of postcolumn fluorescence derivatization using Nash reagent (2000), Anal. Biochem., 284, 342-347.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sertraline + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | i.e. (1S,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a one-step oxidative N-demethylation | demethylsertraline + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
| sertraline + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | i.e. (1S,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a one-step oxidative N-demethylation | demethylsertraline + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aminopyrine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| erythromycin + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| fluoxetine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| S-mephenytoin + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
| sertraline + [reduced NADPH-hemoprotein reductase] + O2 | i.e. (1S,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a one-step oxidative N-demethylation | Homo sapiens | demethylsertraline + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| sertraline + [reduced NADPH-hemoprotein reductase] + O2 | i.e. (1S,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a one-step oxidative N-demethylation | Rattus norvegicus | demethylsertraline + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| N-demethylase | - |
Homo sapiens |
| N-demethylase | - |
Rattus norvegicus |
| O-demethylase | - |
Homo sapiens |
| O-demethylase | - |
Rattus norvegicus |
| sertraline N-demethylase | - |
Homo sapiens |
| sertraline N-demethylase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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