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1.1.1.29: glycerate dehydrogenase

This is an abbreviated version!
For detailed information about glycerate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.29

Reaction

D-glycerate
+
NAD+
=
Hydroxypyruvate
+
NADH
+
H+

Synonyms

D-glycerate dehydrogenase, dehydrogenase, glycerate, GDH, glyoxalate reductase/hydroxypyruvate reductase, glyoxylate reductase, GR/HPR, GRHPR, HPR, HPR1, hydroxypyruvate dehydrogenase, hydroxypyruvate reductase, hydroxypyruvate reductase 1, NADH-dependent hydroxypyruvate reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.29 glycerate dehydrogenase

General Information

General Information on EC 1.1.1.29 - glycerate dehydrogenase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
enzyme knockdown leads to an inhibition of ascorbic acid uptake
metabolism
HPR1 phosphomimetic variant T335D exhibits reduced NADH-dependent hydroxypyruvate reductase activity but improved NADPH-dependent activity. Complementation of the Arabidopsis HPR1 mutant by either wild-type HPR1 or HPR1 nonphosphorylatable mutant T335A fully complements the photorespiratory growth phenotype of the HPR1 mutant in ambient air, whereas HPR1 T335D-containing HPR1 mutant plants remain smaller and have lower photosynthetic CO2 assimilation rates. These phenotypes were associated with subtle perturbations in the photorespiratory cycle of HPR1 T335D-complemented HPR1 mutant rosettes compared to all other HPR1-containing lines
physiological function