1.1.1.29: glycerate dehydrogenase

This is an abbreviated version, for detailed information about glycerate dehydrogenase, go to the full flat file.

Reaction

D-glycerate
+
NAD+
=
Hydroxypyruvate
+
NADH
+
H+

Synonyms

D-glycerate dehydrogenase, dehydrogenase, glycerate, GDH, glyoxalate reductase/hydroxypyruvate reductase, glyoxylate reductase, GR/HPR, GRHPR, HPR, HPR1, hydroxypyruvate dehydrogenase, hydroxypyruvate reductase, hydroxypyruvate reductase 1, NADH-dependent hydroxypyruvate reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.29 glycerate dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.29 - glycerate dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Dihydroxyfumarate
-
-
GSH
-
about 72% residual activity at 2 mM
Hydroxypyruvate
-
product inhibition at a concentration above 4 mM, 99% inhibition of the reverse reaction at 0.5 mM
NADH
-
concentration above 0.5 mM
NADPH
-
concentration above 0.5 mM
p-chloromercuribenzoate
-
-
phenylhydrazine
-
-
S-nitrosoglutathione
-
about 80% residual activity at 2 mM
SIN-1
-
about 35% residual activity at 1 mM
additional information
-